Comparing Differin vs Tretinoin Topical
| Differin (adapalene) | Tretinoin topical |
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| Differin (adapalene) | Tretinoin topical |
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Prescription and OTC
Prescribed for Acne. Differin may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Photoaging of the Skin, Lichen Sclerosus, Acne, Necrobiosis Lipoidica Diabeticorum. Tretinoin topical may also be used for purposes not listed in this medication guide. |
Related suggestions |
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| More about Differin (adapalene) | More about Tretinoin topical | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Differin has an average rating of 6.1 out of 10 from a total of 344 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 36% reported a negative effect. |
Tretinoin topical has an average rating of 7.7 out of 10 from a total of 493 ratings on Drugs.com. 71% of reviewers reported a positive effect, while 14% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Differin side effects |
View all Tretinoin topical side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Differin prices |
View all Tretinoin topical prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other adapalene brands include: Plixda | Altinac, Altreno, Atralin, Avita, Obagi, Refissa, Renova, Retin A Micro, Retin-A, Retin-A and Renova View more | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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51 hours |
N/A |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 12 drugs are known to interact with Differin:
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A total of 12 drugs are known to interact with Tretinoin topical:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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May 31, 1996 |
January 26, 1973 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.