Comparing Dextromethorphan vs Diphenhydramine
| Dextromethorphan | Diphenhydramine |
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| Dextromethorphan | Diphenhydramine |
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Prescription and OTC
Prescribed for Cough. Dextromethorphan may also be used for purposes not listed in this medication guide. |
Prescription and OTC
Diphenhydramine is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side... View more |
Related suggestions |
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| More about Dextromethorphan | More about Diphenhydramine | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Dextromethorphan has an average rating of 3.7 out of 10 from a total of 386 ratings on Drugs.com. 20% of reviewers reported a positive effect, while 63% reported a negative effect. |
Diphenhydramine has an average rating of 5.5 out of 10 from a total of 541 ratings on Drugs.com. 43% of reviewers reported a positive effect, while 40% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Dextromethorphan side effects |
View all Diphenhydramine side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Dextromethorphan prices |
View all Diphenhydramine prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| 12 Hour Cough Relief, Babee Cof, Balminil DM, Benadryl for the Family Dry Forte, Benylin DM, Bisolvon Dry, Bisolvon Dry Junior, Buckley's DM, Buckley's Mixture Cough Suppressant, Buckleys Mixture, Calmylin, Contac Cough, Cough Syrup DM, Covonia Bronchial Balsam, Creomulsion, Creomulsion Children, Delsym, Delsym 12 Hour Cough Relief, Delsym 12 Hour Cough Relief for Children & Adults, Delsym Children's 12-Hour Cough Relief, DexAlone, Dexi-Tuss, Dextromethorphan HBr Adult Formula, Dristan DM, Dry Cough, Duract Max Strength Cough, ElixSure Cough, Giltuss Children's Honey DM 8hr Cough, Giltuss Honey DM 8hr Cough, Hold, Hold DM, Robafen Cough Liquidgels, Robitussin 12-Hour Cough Relief, Robitussin Children's Cough Long-Acting, Robitussin Cough Long-Acting, Robitussin CoughGels Long-Acting, Robitussin Direct Cough, Scot-Tussin Diabetes, Silphen DM, Sucrets Cough, Triaminic Long Acting Cough, Triaminic Thin Strips Cough, Tussin Cough Gels (Long Acting), Vicks Dayquil Cough, Vicks Formula 44, Vicks Formula 44 Custom Care Dry Cough Suppressant, Vicks Nature Fusion Cough View more | Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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3.6 hours |
9.3 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 367 drugs are known to interact with Dextromethorphan:
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A total of 448 drugs are known to interact with Diphenhydramine:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
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No known disease interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| First Approval Date | |||||||||||||||||
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October 08, 1982 |
March 04, 1946 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.