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Apraclonidine ophthalmic Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Apraclonidine ophthalmic Combigan (brimonidine / timolol) Acetazolamide
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Apraclonidine ophthalmic Combigan (brimonidine / timolol) Acetazolamide
Prescription only

Prescribed for Postoperative Increased Intraocular Pressure, Glaucoma. Apraclonidine ophthalmic may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Glaucoma/Intraocular Hypertension, Glaucoma, Intraocular Hypertension. Combigan may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Hydrocephalus, Glaucoma, Edema, Epilepsy, Hypokalemic Periodic Paralysis, Mountain Sickness / Altitude Sickness, Pseudotumor Cerebri, Seizure Prevention, Seizures. Acetazolamide may... View more

More about Apraclonidine ophthalmic More about Combigan (brimonidine / timolol) More about Acetazolamide
Ratings & Reviews

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Combigan has an average rating of 4.9 out of 10 from a total of 25 ratings on Drugs.com. 40% of reviewers reported a positive effect, while 48% reported a negative effect.

Acetazolamide has an average rating of 6.4 out of 10 from a total of 192 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 26% reported a negative effect.

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Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Apraclonidine ophthalmic side effects

View all Combigan side effects

View all Acetazolamide side effects
Drug Class
Generic Availability

Lower cost generic

Lower cost generic approved

Lower cost generic
Pricing and Coupons * Prices are without insurance
Quantity 5 mL
Strength 0.5%
Per unit* $7.41
Cost* $37.06

View all Apraclonidine ophthalmic prices

Quantity 5 mL
Strength 0.2%-0.5%
Per unit* $45.58
Cost* $227.92

View all Combigan prices

Quantity 50 each
Strength 250 mg
Per unit* $2.51
Cost* $125.33

View all Acetazolamide prices

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Dosage Forms
  • Ophthalmic solution
  • Ophthalmic solution
  • Intravenous powder for injection
  • Oral capsule, extended release
  • Oral tablet
Brand Names

N/A

N/A

N/A
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

N/A

7 hours

4 hours
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 398 drugs are known to interact with Apraclonidine ophthalmic:

  • 10 major drug interactions (27 brand and generic names)
  • 354 moderate drug interactions (1499 brand and generic names)
  • 34 minor drug interactions (238 brand and generic names)

A total of 548 drugs are known to interact with Combigan:

  • 29 major drug interactions (169 brand and generic names)
  • 515 moderate drug interactions (2015 brand and generic names)
  • 4 minor drug interactions (12 brand and generic names)

A total of 263 drugs are known to interact with Acetazolamide:

  • 24 major drug interactions (169 brand and generic names)
  • 221 moderate drug interactions (987 brand and generic names)
  • 18 minor drug interactions (56 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • After using apraclonidine ophthalmic, some of the medication may be absorbed into the bloodstream... View more
  • After using brimonidine ophthalmic, some of the medication may be absorbed into the bloodstream and... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease Interactions
First Approval Date

N/A

October 30, 2007

July 27, 1953
WADA Class View classifications

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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