Comparing Amphetamine vs Methylphenidate
| Amphetamine | Methylphenidate |
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| Amphetamine | Methylphenidate |
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Prescription only
Prescribed for ADHD, Narcolepsy, Weight Loss (Obesity/Overweight). Amphetamine may also be used for purposes not listed in this medication guide. |
Prescription only
Methylphenidate can help improve symptoms of ADHD but may cause dependence and side effects include a headache, loss of appetite, and sleeplessness. It is recommended that methylphenidate should not... View more |
Related suggestions Weight Loss (Obesity/Overweight)
ADHD (Attention Deficit Hyperactivity Disorder)
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| More about Amphetamine | More about Methylphenidate | ||||||||
| Ratings & Reviews | |||||||||
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Amphetamine has an average rating of 6.5 out of 10 from a total of 141 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 30% reported a negative effect. |
Methylphenidate has an average rating of 7.2 out of 10 from a total of 1082 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 17% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||
View all Amphetamine side effects |
View all Methylphenidate side effects |
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| Drug Class | |||||||||
| Generic Availability | |||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Methylphenidate prices |
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| Dosage Forms | |||||||||
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| Brand Names | |||||||||
| Adzenys ER, Adzenys XR-ODT, Dyanavel XR, Evekeo, Evekeo ODT | Aptensio XR, Concerta, Cotempla XR-ODT, Daytrana, Jornay PM, Metadate CD, Methylin, Methylin ER, QuilliChew ER, Quillivant XR, Relexxii, Ritalin, Ritalin LA View more | ||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||
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17 hours |
4 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||
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High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
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| Pregnancy Category | |||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||
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A total of 220 drugs are known to interact with Amphetamine:
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A total of 207 drugs are known to interact with Methylphenidate:
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| Alcohol/Food/Lifestyle Interactions | |||||||||
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| Disease Interactions | |||||||||
| First Approval Date | |||||||||
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August 31, 1984 |
December 05, 1955 |
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| WADA Class View classifications | |||||||||
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N/A |
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| More Information | |||||||||
| Patient Resources | |||||||||
| Professional Resources | |||||||||
| Related Treatment Guide | |||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.