Comparing Acetaminophen / Chlorpheniramine / Phenylephrine vs Diphenhydramine
Acetaminophen / chlorpheniramine / phenylephrine | Diphenhydramine |
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Acetaminophen / chlorpheniramine / phenylephrine | Diphenhydramine |
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Prescription and OTC
Prescribed for Sinus Symptoms, Cold Symptoms. acetaminophen / chlorpheniramine / phenylephrine may also be used for purposes not listed in this medication guide. |
Prescription and OTC
Diphenhydramine is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side... View more |
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More about Acetaminophen / chlorpheniramine / phenylephrine | More about Diphenhydramine | ||||||||
Ratings & Reviews | |||||||||
Acetaminophen / chlorpheniramine / phenylephrine has an average rating of 7.6 out of 10 from a total of 21 ratings on Drugs.com. 72% of reviewers reported a positive effect, while 22% reported a negative effect. |
Diphenhydramine has an average rating of 5.5 out of 10 from a total of 529 ratings on Drugs.com. 43% of reviewers reported a positive effect, while 41% reported a negative effect. |
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Drug Class | |||||||||
Side Effects | |||||||||
See also: acetaminophen / chlorpheniramine / phenylephrine side effects in more detail. |
See also: diphenhydramine side effects in more detail. |
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Generic Availability | |||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | |||||||||
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all diphenhydramine prices |
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Dosage Forms Available | |||||||||
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Brand Names | |||||||||
Allergy Multi-Symptom, Allergy Pain Relief, Allergy Sinus PE Pain Relief, BC Sinus Pain & Congestion, Comtrex Flu Therapy, Comtrex Severe Cold & Sinus, ConRx Allergy Sinus, Contac Cold + Flu (Night Formula), Dristan Cold Multi Symptom Formula, Dryphen, Gendecon, GNP Cold Relief Plus, HEB Allergy, Hybrid CF, Medicidin-D, Norel AD, Onset Forte, PX Allergy Sinus PE, Pyrroxate, Relief-PE, Robitussin Peak Cold Nighttime Nasal Relief, Sine-Off Sinus/Cold, Super Strength Sinadrin, Tylenol Allergy Multi-Symptom, Tylenol Plus Children's Cold, Tylenol Sinus Congestion & Pain Nighttime, Tylenol Sinus Congestion and Pain Cool Burst Day Night, XL-3 Cold Medicine View more | Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | ||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||
30 hours |
9.3 hours |
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CSA Schedule ** View glossary of terms | |||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||
Category N
Not classified
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||
A total of 578 drugs are known to interact with acetaminophen / chlorpheniramine / phenylephrine:
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A total of 448 drugs are known to interact with diphenhydramine:
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Alcohol/Food/Lifestyle Interactions | |||||||||
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Disease Interactions | |||||||||
First Approval Date | |||||||||
N/A |
March 04, 1946 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||
N/A |
N/A |
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More Information | |||||||||
Patient resources | |||||||||
Professional Resources | |||||||||
N/A |
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Related Treatment Guide | |||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.