Effexor XR for Depression User Reviews

• Dor...
• Taken for 5 to 10 years
• January 3, 2021

"In a few paragraphs, I can gladly proclaim this medication saved my life in so many ways! I had never felt content until I took Effexor. The grass was greener, the music was even more beautiful, I am now kind and patient again; I am simply happy! I don't need to constantly seek out pleasurable things to make life more exciting anymore. I’m not so emotionally vulnerable. For the first time in my life, I can READ! My ADHD has diminished 70% - 90%! Whether it be from ADHD, anhedonia or both, I can FINALLY enjoy the simple things in life. Lastly and miraculously, my IQ went up 15 - 20 points! My thought process is much more clear, and I LOVE reading and learning! My newfound curiosity fuels my joy for living and learning. I want to thank the people who created this drug. I am not only myself again, but I’m someone I never even knew I was capable of being!"

• Joe...
• Taken for 10 years or more
• May 10, 2019

"I am a 43-year-old man. I take Effexor XR 150mg since 2000 (yes, I know it is long, but it is better than death). Okay, every 2-3 years I try to be 'med-free', 'normal', and 'out of the stigma', and each time it is the same. I crash. Hard. Each time, I play with my life. From the outside, I look successful, brilliant, intelligent, normal, etc. But I am sick as hell. Sick, but in treatment. I take care of me as I could, and I really don't care about what people think about Venlafaxine now. I don't want to die. Believe me, noradrenaline and serotonin recapture is no garbage. You may need a little help for your brain. Refuse it if you like, but do something about depression before it will do something about you."

• Ale...
• October 13, 2020

"Please remember to give Effexor XR a couple of months to work. The first month or even two are going to suck. Why? Remember that the chemicals in your brain are adjusting. We have a chemical imbalance. Be patient and kind to yourself. I was on Lexapro and it worked, but I gained so much weight, so I got off. Not a good idea. Never just go cold turkey! So, after speaking to my doctor, he put me on Effexor, and it has been such a blessing. I’m on 225mg for over 3 years, and while I do have good and bad days because it’s not a miracle pill, you still have to fight the depression and anxiety, but it helps you fight it. Stay strong! It works. Be patient. Don’t be scared."

• Tep...
• June 4, 2020

"I had severe anxiety in 2016. It was truly crippling. Along with panic attacks and thinking I was dying all the time, I experienced depersonalization/derealization every day. Effexor XR truly saved my life. I take my pills at night, and if I miss one dose, I know immediately the next day by how I feel. It’s a horrible feeling. I also described it as my head was skipping, but I see others describe it as brain zaps. That’s truly what it feels like. Besides that though, this medication changed everything for me."

• Taw...
• Taken for 1 to 6 months
• February 18, 2020

"I take 150mg time-released Effexor. I am dealing with a head injury for 6 months now. I have been on Effexor since. I have no side effects, and it has really helped me with my anxiety, nervousness, and depression. This medicine is such a lifesaver. I can go to work and be around people. I don’t know where I would be without this medication."

• Tol...
• August 29, 2015

"I have been on many antidepressants over the years. I have had depression and anxiety since I was 21 years old, and am in my late 40s now. Other antidepressants caused horrible cravings for sweets and carbs. Plus, the medications didn't work that well for me. I have been on Effexor for 8 months, 150 mg. It works wonders for me. I actually like to be around people now. I go places, etc. I have a life again and noticed that I get excited about life. Also, I have lost weight on it. My cravings are gone, I feel full after a meal, and full a lot longer after the meal. I am gaining back my energy. I am a woman who was so severely depressed, I couldn't even get out of my recliner and didn't get dressed most days. What a difference!"

• hba...
• Taken for 1 to 6 months
• June 20, 2013

"This medicine saved my life. I was at my wits' end with antidepressants and was ready to give up. My doctor finally prescribed me this after many failed medications. I am so glad she did. I honestly do not know where I would be without Effexor XR. Side effects were very mild compared to other antidepressants I tried. I was drowsy for the first couple of days, but it was tolerable. I highly recommend this for severe depression. I would also like to mention for people to realize there is light at the end of the tunnel and YOU WILL GET BETTER, and to never give up."

• Rya...
• January 23, 2020

"This drug is by far the best antidepressant I've taken, and I've been on it since age 17 (now 34). If you miss a day, you will be very emotional, but other than that, I haven't noticed many bad side effects. My depression is great now and has been for years. The only negative is my lack of sex drive and sleeping a lot. Not sure if that's all due to the medication or just my lazy arse. Heard a lot of bad reviews, but honestly, I've been on it for 7 years and I think it's great."

• Gra...
• Taken for 5 to 10 years
• February 4, 2020

"Everyone's different, for me this one's a LIFE SAVER! My depression began 15 years ago. In 2014, I hit my lowest point. Previous doctor had me on several meds that didn't mix well together. That whole year is a blur, I don't remember any of it except for the few grand mal seizures they caused. Eventually, I attempted suicide with one of the meds and ended up in a mental hospital twice within a month. My new psychiatrist took me off everything and started me on this, topped out at 150mg (which I am to this day, 6 years later, still taking). I can't thank that psychiatrist and this miracle drug enough. Taking with Bupropion (Wellbutrin) and I'm not sure which one, but I believe one of them has got rid of my sex drive. I prefer no sex drive over that really dark place I was in. Also, if I miss taking them a couple of days in a row (again, not sure which one is causing it), I experience extreme vertigo... not fun. Other than that, I have no other complaints, just absolute gratefulness. LOVE IT!"

• NLD...
• Taken for 6 months to 1 year
• May 2, 2014

"I've tried many different SSRIs for depression (Zoloft, Wellbutrin, Prozac) and nothing worked. I was apprehensive to take Effexor because of online reviews, but I'm so glad I did! The only side effect I've had is tiredness the first few weeks, but that has since subsided. I not only feel more energy, but I actually can feel happiness. On the other medicines, I just felt numbness and a lack of emotion, but Effexor has made me feel like me again! This has been my miracle after years of mild to severe depression."

• Cma...
• Taken for 1 to 6 months
• August 16, 2019

"After 15 years of struggling with deep depression, PMDD, and postpartum depression, 1 suicide attempt, and 1 hospitalization, I have found the medicine Effexor that has worked for me. It's been a long road, but now I'm at peace and living life to the fullest."

• Eff...
• Taken for 10 years or more
• October 17, 2018

"Been on Effexor 150 mg for 16 years. Can't remember any side effects that weren't tolerable. I haven't had one problem in 16 years of taking it. I have had three clinical depression episodes (about ten years apart) so I have to stay on an antidepressant for the rest of my life. I like to say... I'm a 'quart low' on serotonin. Effexor has kept the level up. Happy patient!"

• Ash...
• Taken for 1 to 6 months
• July 6, 2023

"This drug saved my life. I've been taking it on and off since 2017 at 225mg. Now, I have struggled with depression for 18 years - constantly crying, feeling hopeless, and wishing I was dead. I've been through several psychiatrists and several different meds. Nothing helped. My anxiety was bad. I couldn't keep friends or maintain relationships. I was on the verge of taking my life because I was in so much pain. Then, I was given Effexor when I was in the mental hospital, and it has helped me a lot and saved my life. It's the best medication I have ever taken. I don't feel anxious or depressed anymore. I got my life back, and I'm happy once again. The people who left bad reviews are overdramatic and sound like lunatics. This drug is amazing. No bad side effects besides drowsiness. It may not work for everyone, but it surely helped me, and I am so grateful I finally found a medication that works tried and true!"

• VIR...
• April 11, 2014

"I've been taking Effexor for 4 weeks. Finally, I feel good. It's a miracle! I was suffering real bad depression and anxiety, and thoughts of giving up on life. Effexor works. This is the best I've felt since I was 23. Now I'm 30, and yes, I feel very happy to know I didn't give up and finally found a miracle pill. It's only been a month. Thanks Effexor, saved my life. Thank you."

• JLf...
• Taken for 1 to 6 months
• June 9, 2024

"After 7 years on Zoloft, I tapered to 25 mg from 100 mg. Then depression hit. I tried titrating up, but dealt with sedation and many adverse side effects. I tapered off and quit for 30 days. Depression lingered, so I began 37.5 Effexor. I felt relief on the first day. I switched to taking it in the evening to offset morning sleepiness. Within 2 weeks, I went to 75 mg, and within 2 weeks, depression remitted. After 15 weeks at 75 mg, I'm on a staggered dose of 112.5/75 every other day. Here's the thing for me—I chose to start low and go slow. The Effexor gave a mild but noticeable lift in mood. Within 2 weeks, I felt hope. I didn't have to wait 4 to 6 to 8 weeks to notice nor suffer adverse effects for weeks at a time. Research supports the efficacy of Effexor, especially its ability to give noticeable, if not subtle, improvements within two weeks. Having gone 40 weeks suffering adverse effects of Zoloft, the impact of Effexor for me was, in fact, life-changing. (Male, 62)"

• Nat...
• October 21, 2019

"I have struggled with eating disorders (Anorexia and Binging) for about 4 years now. It started at 16 and slowly began to follow me into college. I’ve struggled with relationships and often find myself extremely depressed and more anxious than ever. I started Effexor about 2 weeks ago now, and the first few days were much like the experiences listed on here. I have done MDMA before, and it does feel like that for the first two days. However, after I got through that stage, each day has been getting better. Colors seem brighter, and my motivation has started to get better. Before, I had struggled with finding any interest in life, and everything seems a little bit more open each day I wake up. I do have some very vivid dreams and find that during the night, my depression gets a little worse, but it has slowly subsided, and I’m able to push away thoughts that normally frustrate me. I’m excited to see how each day goes moving forward."

• Heb...
• September 5, 2013

"I have been on Effexor XR for over 15 years. I take a daily dosage of 300mg. It has been the most significant thing in my life! I am able to function normally, hold down a sometimes stressful job, be a great parent, and most of all be the best me possible. I have a hormonal imbalance which causes my depression, and no amount of psychological intervention was ever going to change that. Effexor XR did. Whilst there are side effects, my body has become accustomed to them, and believe me, they are nothing in comparison to the dreadful depression. I believe that it has saved my life and ensured that the life I lead is a good one. A couple of tablets a day, some minor side effects, and I can get on with a wonderful life."

• ree...
• January 25, 2015

"I started taking Effexor 3 weeks ago after finding no success with Wellbutrin or Zoloft. It causes some initial bad side effects (nausea, dizziness, tiredness), but I can't emphasize enough how wonderful I feel now! I thought I would never find a solution. Most effective medication I've encountered thus far!"

• jla...
• Taken for 1 to 2 years
• April 22, 2019

"This (Effexor XR) is a GREAT drug! For those of you who have had a bad experience, you need to have the swab test done by your Dr (covered by insurance) to find out what drugs work for you. It has been a lifesaver for me! I was switched by a smart NP after taking Paxil for many years with many problems. After I took the mouth swab test & it showed Paxil was a bad fit for me. I have zero side effects aside from a little weight loss, which for me is awesome as I'm 57 & fit but had those nagging extra lbs. Extra lbs gone, mood lifted, don't dwell on stupid things. I'll be on it forever as I'm permanently low in serotonin & NEED the boost. Without it, I just lay in bed & don't want to do anything. Get the swab test done & if this shows up in the left column, try it! Little adjustments with dosage are required - just start at 75mg, which helps a teenie bit & then go up... It's also cheap if you pay cash... GOOD LUCK!!"

• Cra...
• Taken for 2 to 5 years
• February 11, 2020

"I originally started on the regular Effexor when I was 16 after a suicide attempt while on Prozac. This was literally a lifesaver for me! Switched to XR when it became available. I was on it for about 3 years before deciding I no longer wanted to be anchored down by antidepressants. The withdrawals sucked, but didn't last long. I'm considering going back on it and am now 37 years old."

• Fog...
• November 6, 2016

"Effexor XR saved my life! I had severe clinical depression for one year, and my doctor tried 8 different antidepressants on me, all to no avail. I sought the help of a psychopharmacologist in Palo Alto, CA. He met with me for 90 minutes, did an evaluation, and prescribed Effexor XR for me. He stairstepped me up to 300 mg/day within 12 days, and within 2 weeks I felt like my old self again. It felt miraculous. I may be on it for the rest of my life, but I don't mind one bit. I am enjoying life again!"

• Int...
• Taken for 1 to 6 months
• April 14, 2021

"I have tried several different medications and every supplement, including thyroid, kelp, etc., since my three-year battle with depression. Effexor didn’t do much for me for about 12-16 weeks, but I noticed a difference. The first 8 weeks, I had terrible insomnia, and I nearly stopped it. Having looked up treatment-resistant depression, I decided to try taking folate, and 6 weeks later, it’s the first time I’m feeling 90% like myself again. I’m not sure if it’s the Effexor, the folate, or both, but if you're not feeling like the meds are helping 100%, I would consider adding folate. Don’t give up."

• abd...
• Taken for 1 to 6 months
• June 21, 2021

"I read a lot before taking this medicine because I heard about its horrible side effects and withdrawal symptoms, but finally, I decided to take it as I believe all depression medications have side effects and withdrawal symptoms, and for sure it won't be worse than depression. And if it's approved by the FDA and allowed in most countries, then for sure it has also positive effects more than negative ones. After I took it, I felt it change the depression after the first dose! Now, after 3 months of it, it's the best medication I've tried so far. But please know it has different effects from person to person. For me, the side effects were some nausea and night sweating, and that was only for one day. After that, no side effects happened. So finally, I tell you don't be afraid to take it - it is a safe and strong antidepressant."

• Bla...
• Taken for 1 to 6 months
• July 11, 2015

"I have not been able to stay awake for more than a few hours at a time and so depressed that I couldn't go out in public. But since I have been taking Effexor, I am 100% better. I am a new person. I want to get out and do things, and I have a sense of well-being. I love this feeling!! It's like a new me. I am better than ever."

• Pro...
• Taken for 2 to 5 years
• December 19, 2019

"31/m. I have been on Effexor XR generics for 5 years after nearly committing suicide at the age of 26. It has completely gotten rid of my suicidal ideation as well as tremendously reducing my depression and anxiety. Without it, I'm quite certain that I would not be alive today. After trying to get off of it a couple of times and having those bad feelings come back, I have become resigned to the fact that I will likely be on this drug for life, but am okay with that to be honest. I don't really have any side effects from the drug, at least not that I am aware of. The reason I give it 8 stars is because if you ever DO want to get off of it, the withdrawal symptoms are absolutely horrendous."