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Zilretta User Reviews & Ratings (Page 2)

Zilretta has an average rating of 5.8 out of 10 from a total of 54 reviews on Drugs.com. 43% of reviewers reported a positive experience, while 43% reported a negative experience.

Reviews for Zilretta

  • DanA
  • Taken for less than 1 month
  • January 27, 2020

For Osteoarthritis "I had a shot of this medication in my knee and I have had severe leg cramps and we I asked the doctor about how long the side effects were going to last he said 3 to 4 days. At this point I can hardly walk.. I definitely would not recommend this drug. Additionally I believe Cortizone is better in this stuff. Good night cramps are unbearable I drink a lot of water to stay hydrated."

1 / 10
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6 Report
  • Pat
  • Taken for less than 1 month
  • September 25, 2020

For Osteoarthritis "First shot worked great. Second shot I had severe pain and a burning sensation on the side of my knee that faces the other knee. This pain lasted 4 days and about drove me out of my mind. I kept thinking he injected into a nerve or something that shouldn't have been stabbed. It was horribly painful & I'm really good at handling pain but I was ready to have this leg amputated on day 3. Finally on day 5 it let up. Injection spot stayed red and swollen for two weeks. Now the shot is helping. I'm scheduled to get a third injection in December. If it reacts like the second one I'll know I'm allergic. However seems weird I had no reaction to the first shot then 7 months later the second shot nearly drove me insane. Made my whole body hurt. Especially my back. Never could get my doctor's office back on the phone. Now 3 weeks later and calling twice a week and leaving messages they don't return phone calls."

7 / 10
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5 Report
  • Anonymous
  • Taken for less than 1 month
  • July 30, 2020

For Osteoarthritis "I have partial replacements in both knees and they are both bad again. I got the Zilretta shot a week ago and had great pain relief at first but on day 7 started increasing pain. Not sure if this is gonna work. Trying to buy time before total replacements."

2 / 10
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5 Report

Frequently asked questions

  • weary...
  • Taken for less than 1 month
  • September 14, 2020

For Osteoarthritis "Received drug Zilretta about 15 days ago. It was FABULOUS these last 12 days! Climbed steps, played with 8 yr old grandson in yard, just generally moved beautifully! Gradually, the pain has returned. Don’t know why, don’t know if I did something wrong, but those first 12-14 days were awesome ! Glad it helps others"

7 / 10
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5 Report
  • SheriL
  • Taken for less than 1 month
  • June 13, 2021

For Osteoarthritis "I fell at work more than 2 years ago, broke my patella, after 3 surgeries and the last one seemed to have worked well, my pain level was down to a 2-3. My doctor suggested getting this injection to get me lasting pain relief going forward, I wish now I hadn't. My pain level increased to at least to a 5 within in a week, sometimes it hurts as much as a 6-7. I have pain where I didn't have pain before, Calling my doctor this week. My surgery was at the end of April, the injection was done at 4 weeks. I am now 3 weeks past injection date and it is only worsened my knee pain. I am so over this knee pain."

1 / 10
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4 Report

Are you taking this medicine?

  • Relief
  • Taken for 2 to 5 years
  • April 15, 2022

For Osteoarthritis "I suddenly developed horrible knee pain in my left knee (Arthritis and meniscus pain). It became so bad that I was told surgery was probably the answer. I couldn't take the time due to my husband going in for major heart surgery. The doctor gave me this injection and said it should last 6 months to maybe a year. It has been over THREE YEARS and my left knee is still pain free!! I have another doctor and they have been trying to treat my right knee for over a year. The shots they have been trying are not working. I THOUGHT they were the same shot as this one but I found out it isn't. Hopefully, now I can get the same relief as I got with my left knee. I haven't slept a full night for nearly 9 months due to pain in the night. I don't understand why this new doctor didn't try it. Miss my old doctor!!"

10 / 10
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3 Report
  • Anonymous
  • February 10, 2022

For Osteoarthritis "I have bone on bone and bone spurs and it did not work for me yet it’s been 10 days and it’s really swollen and now there’s crunching. It was very painful afterwards and it didn’t hurt at all getting it but now awful pain and a horrendous runny nose. I am definitely regretting getting it."

1 / 10
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3 Report

More FAQ

  • Feeling...
  • Taken for less than 1 month
  • December 13, 2022

For Osteoarthritis "My right knee is almost bone on bone. My left knee isn't as bad but still hurts. I have tried cortisone and gel injections. Neither worked for me. My doctor suggested I try Zilretta. I had an injection in both knees 5 days ago. I am having really bad headaches, and my kneecaps are very painful. I am also experiencing fatigue. It's hard to believe all this would be from the Zilretta, but I can't attribute my symptoms to anything else. I don't think I will be getting any more of these injections. My doctor says I'm too young for knee replacements, but I'm in so much pain."

1 / 10
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2 Report
  • Fitzm
  • Taken for less than 1 month
  • October 22, 2020

For Osteoarthritis "I got the injection into my knee 10 days ago. Initially, I had significant burning pain and pressure in my knee x 3 days, This has resolved and now I have severe hamstring tendinitis With difficulty doing stairs and walking up hills. I’m sorry I even got this injection, my discomfort is so much worse that I was at baseline."

1 / 10
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4 Report
  • Barbie
  • Taken for less than 1 month
  • July 28, 2021

For Osteoarthritis "PLEASE, PLEASE do some research before getting this injection. I just had today, 7/28/21 and it was a nightmare. It was a really painful injection, then when I got off the exam table I could barely walk. I told the nurse that I couldn't walk to my car and she said to sit in the waiting area for a few minutes. Within 2 to 3 minutes I started feeling really ill so I called them for help. I broke out in a dripping sweat, hyperventilate, vomited a lot and had diarrhea all over myself. They said they didn't think it was an allergic reaction but suggested that I might want to go to ER and get checked out. I did not want to go the the ER due to the COVID numbers being up and I would sit there for hours. It's been several hours now and I still feel dizzy and queasy. I will call 911 if I have to. This is the last Zilretta injection that I will ever take. I am taking Augmentin, but had not had one this morning. I told them this before the injection."

1 / 10
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3 Report
  • Dallas
  • Taken for less than 1 month
  • September 28, 2022

For Osteoarthritis "Pain relief was substantial following an injection in each knee in July 2022 and last approximately 4 weeks. Unfortunately, I had very noticeable mood side effects - which has occurred previously when taking steroids. Pain returned and 2 months post injections my knee pain is significantly worse than before, as well as more clicking/popping in knees. I can barely ascend/descend stairs much of the time. Did not work and was a huge mistake for me."

1 / 10
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2 Report
  • Janetk
  • Taken for 1 to 6 months
  • June 6, 2021

For Osteoarthritis "I have suffered for 4 yrs with OA and the last year was awful, I have tried everything and eventually all the doctors told me was lose weight and I was not going to do it by exercise. I needed a knee replacement and was too young. In March I finally found a wonderful Dr who listens and came up with a plan. I had the Zillreta injections in both knees on the 29th of March and it has changed my life, I can actually do things, and not be in excruciating pain. 10 weeks in and I'm getting minimal pain back so I'm hopeful that when I need another injection it continues to work. I will forever be grateful to my Dr for introducing this to me."

10 / 10
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  • Gary
  • Taken for 1 to 6 months
  • May 6, 2022

For Osteoarthritis "Issue is osteoarthritis of the knee and a partially torn meniscus. Had GenVisc850 injections (5 over 5-weeks as required), but still had knee pain so doctor prescribed a Zilretta injection. Within 1 day, my knee pain became a lot worse, then for about 2-weeks the pain subsided some so I thought the Zilretta was finally working. The relief was short term and the pain increased to the point where it was difficult to put any weight on my leg. Now, 6-weeks after the Zilretta injection, I am scheduled for surgery."

2 / 10
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  • Colleen
  • Taken for less than 1 month
  • March 18, 2022

For Osteoarthritis "The first 9 days was great, no pain but after that it has been getting worse to the point of being totally miserable. It has been over a week with bad pain in my inner knee area. No OTC meds, icing, or heating helps it."

5 / 10
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  • Painp...
  • Taken for 1 to 6 months
  • September 13, 2021

For Osteoarthritis "I have bilateral knee pain and I got bilateral zilretta injection. I really wish I hadn't. There was no pain in left knee one week and right knee three weeks. Pain came back in spades couldn't bear down on left knee and then it cleared up. Next right knee excruciating pain cant bear down or walk. I went to emergency room. Pain pills helped for a little while. I was sent to pain management. Nothing is helping. I'm in pain as I text even when taking Oxycodone."

1 / 10
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  • Anona...
  • Taken for 1 to 6 months
  • July 12, 2022

For Osteoarthritis "I have been suffering from severe ITB pain following a hip revision 6 months ago. My Doctor ordered an MRI which revealed mild arthritis and a partial meniscus tear in my knee on the same leg. I had no knee pain whatsoever, only it band. He suggested Zilretta. My ITB is so irritated I can barely walk. It's also affected my back, hamstrings and tendons. It's been 6 weeks of misery on top of what was already bad. Big mistake."

1 / 10
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  • silve...
  • Taken for 6 months to 1 year
  • August 23, 2022

For Osteoarthritis "I'm 79, I have arthritis under both patellas. Zilretta is a great product. Both knees have been treated 4 times. Treatments lasted only 2 months. (I tried exercise and no exercise.) I was asked if I wanted to try Hymovis or Eflexa. I checked the product reviews and I'll stay with Zilretta. I have no stiffness, swelling or other complications."

9 / 10
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  • D W R
  • Taken for 1 to 6 months
  • July 10, 2021

For Osteoarthritis "Zilretta has been like a "magic elixir" for my knees. Since I had the original injections in both knees in March, 2021, they have been virtually pain free from any arthritis. I've been able to do things (like squat) that I haven't been able to do for years. I couldn't have a higher recommendation for the treatment in spite of its cost."

10 / 10
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  • Anonymous
  • Taken for 1 to 2 years
  • April 26, 2024

For Osteoarthritis "On my 4th go-round with Zilretta in 1.5 years. First year lasted nearly 5 months, not the last time. Only 3 months at best. This is the first time the pain has not totally gone away a few days after the injection. Still feel a pinch on the inside of the knee when getting up. While it was an 8 the last few times, I now think it’s only a 5-6 positive. In the past could dance and take low impact a week later. Not this time. It may be a medication that loses effectiveness after multiple shots."

6 / 10
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  • Geno
  • Taken for less than 1 month
  • June 8, 2024

For Osteoarthritis "My knee doctor recommended Zilretta, so I had it injected in my right knee. It felt great at first, but then 4 weeks to the day, the pain came back. Making another appointment on Monday to see what's next. I guess each person has a different effect. Worked great while it lasted."

6 / 10
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  • Sandy
  • Taken for less than 1 month
  • May 30, 2023

For Osteoarthritis "I have been having knee pain for a long time and had Cortisone injections several times. The injection helped for a while, but the pain would return. This time the pain was intense and it was too soon for another Cortisone injection. My Rheumatologist suggested Zilretta. I had the injection last Thursday after fluid removal. Today is Tuesday. I have been pain free, able to walk and bend my knee since Tuesday! We will see how it goes, but for now, I am very happy he recommended Zilretta."

10 / 10
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  • Teresa
  • Taken for less than 1 month
  • July 6, 2022

For Osteoarthritis "I have been getting steroid injections in both knees since 2010. My doctor discussed trying this drug due to my Diabetes because it is suppose to not raise blood sugar numbers after the injections like other steroids do. But, leave it to me to be different I received my injections last Thursday and my blood sugar numbers have been on the up side of 300 since last Friday. So, I guess this medication is a no for me."

3 / 10
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  • BEI
  • June 23, 2019

For Osteoarthritis "I had the Zilretta injection in my knee 5 weeks ago and have been Pain Free with No side effects!"

10 / 10
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26 Report
  • Lady...
  • Taken for 1 to 6 months
  • September 26, 2019

For Osteoarthritis "Lasted about a week. I am try to put off a knee replacement. Last option was Zilretta after having 3 cortisone shots."

2 / 10
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11 Report
  • ab3620
  • Taken for 1 to 2 years
  • February 3, 2021

For Osteoarthritis "I LOVE ZILRETTA!!!! It has worked wonders for me"

10 / 10
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5 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.