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Tramadol for Depression User Reviews (Page 2)

Brand names: Tramadol Hydrochloride ER, ConZip Qdolo

Tramadol has an average rating of 9.3 out of 10 from a total of 217 reviews for the off-label treatment of Depression. 91% of reviewers reported a positive experience, while 3% reported a negative experience.

Reviews for Tramadol

  • Black...
  • November 23, 2014

"SAVED MY LIFE!!! I was struggling with anxiety, depression, PTSD from a particularly rough childhood, and motivation for years. I could never get out of bed in the morning or get anything started (especially completing something). I also used to get traumatic night terrors. Tramadol changed everything. Every day I leap out of bed at 6 am, bounding with energy and motivation. I got my dream job, worked so well that I got promoted to a Senior position within 2 months of starting, and was able to earn enough to move into an even bigger house than what I used to live in. Also have had zero negative side effects! No messing with weight, libido, and no 'crashing' or depressive lows when coming off it. 11/10 for treating depression!"

10 / 10
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  • Sunny...
  • June 24, 2015

"I can't believe the difference tramadol has made in lifting my mood. I began tramadol for body aches and realized the mood elevation that accompanied it. I take 3 50 mg tablets per day and have had no need to increase the amount. I feel motivated and have energy probably the way most non-depressed people do. I used to abuse alcohol and smoke excessively, but now have absolutely no desire to self-destruct. I am more successful and productive in my career, and I believe this pill has given me my life back."

10 / 10
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  • Trama...
  • Taken for 2 to 5 years
  • January 31, 2015

"I have been on EVERY antidepressant over 20 years. I was prescribed Tramadol for a toothache. Not much help on the pain, but within an hour, I felt hope, energy, and have been on the same 200mg for 4 years without any problems!!!"

10 / 10
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157 Report

Frequently asked questions

  • happy...
  • June 8, 2015

"I think there is a reason the government has made Tramadol a Category C drug...they want people in society to take it but everybody in society just wants to get high. Tramadol is the best DEPRESSION, ANXIETY, MILD PAIN MEDICINE EVER. This actually is better than everything without the high. If you actually wanna be a happy person without being high, this is it. 50 mg am - optional second until the next day. Forget the critics. I would say this is like Adderall, without the hunger side effects, lack of sleep, personality disorder, grumpiness, depression, etc. The best thing about it is the government is only selling it for $4 dollars. You don't even need health insurance."

10 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • June 17, 2012

"Have taken Tramadol for depression after being labeled treatment-resistant. I have tried all SSRIs, all SNRIs, and one tricyclic antidepressant and did not respond to any of them. Tramadol is the only medicine to bring depression relief. Scientific research at the University of Cincinnati supports this claim as Tramadol is thought to have SNRI properties and may even help OCD in some. Love it."

10 / 10
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Are you taking this medicine?

  • Healt...
  • Taken for 1 to 2 years
  • August 29, 2017

"I was put on Tramadol for pain, and a funny thing happened. I noticed I felt more energy and overall well-being. I had felt a bit depressed over the years, and they tried a few meds, but none seemed to work. I had surgery and was given Tramadol. Once the pain was gone, I stopped it and noticed I fell back into my old slump. I was in therapy and tried everything. Years later, I went to Mexico for business and saw Tramadol in the pharmacy. I bought one bottle of 50mg capsules and said, 'Let's try this.' 50mg twice a day. Within 2 weeks, people were commenting I seemed like I was happier. It does not give me a high like hydrocodone and other opiate meds. They need to explore this and stop shooting it down as an antidepressant."

10 / 10
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  • Olly...
  • Taken for 1 to 6 months
  • November 28, 2016

"It's by far the most efficient medication for my depression and social anxiety with negligible abuse potential and no side effects. The problem is my psychiatrist refuses to prescribe it to me and even threatened to sue my GP over prescribing it to me for depression. She would rather have me on expensive, inefficient stuff with tons of side effects because of big pharma lobbying and money she gets from it... Sick world we live in."

10 / 10
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More FAQ

  • Makpaz
  • Taken for 2 to 5 years
  • May 9, 2017

"Weight loss: I lost 21 lbs in 4 months. Better mood = Less appetite = More exercise. Lost craving for carbs. Instead, crave protein. Hike and swim every other day. Sex drive went down, not to zero though, maybe from 8 to 3 (Male), but feeling so much better overall. Well-being without sex. Weird but possible. Once daily 50 mg. Welcome to the new me. This is the first antidepressant I ever took. In summary, feel happier and lost 21 lbs (from 221 to 200). More productive at work. Self-employed, lost money due to depression. Now much better, back to the rat race and loving it. By the way, Tramadol metabolizes better in some people based on ancestry, so I read. It works for me (Sicilian descent). Note: most doctors are reluctant to prescribe tramadol for depression."

10 / 10
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  • Cadie...
  • Taken for 1 to 2 years
  • March 29, 2024

"Been suffering with depression here and there since 12th grade. I am 44 now. In 2022, I lost my son and depression set in again. While being treated for pain with tramadol, I realized that I felt happier and my mood tremendously improved. I took to the internet for research and found out that tramadol works for depression. Tramadol has saved my life."

10 / 10
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  • Jame
  • January 13, 2020

"I actually found tramadol worked for depression while being treated for pain in the back. I noticed how great I began to feel. No depression and actually felt like myself for the first time in years. So I actually had a long talk with my psychiatrist, and after showing him several articles from various sources, such as the NEJM, and much more, and telling him of my experience using it for pain and how it uplifted me, he finally agreed to it on a trial basis. I haven’t looked back since. Now I still take my other depression meds. The tramadol is an additional drug. Yes, it is addictive, and no, I don’t care. Your body will start showing signs of tolerance, and you may need to adjust your dosage over time. I recommend starting on the lowest dosage that works for this reason. Do not abuse it because it makes you feel high or buzzed. This will increase the quickness in tolerance, and you will eventually run into the ceiling on daily maximum dosage."

9 / 10
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  • itsam...
  • Taken for 2 to 5 years
  • October 31, 2016

"I have been using tramadol for my depression, anxiety, and it has also helped me quit drinking and smoking. This has been a miracle for my mental health wellness. I have tried everything, and nothing works better than tramadol. Plus, it helped me stop drinking, which was huge!"

10 / 10
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119 Report
  • out...
  • December 18, 2014

"After hurting my back, hips, and developing sciatica from lifting people in hospitals/nursing homes/rehab/home care, I was given Ultram for the excruciating pain. It worked wonderfully without the dopiness associated with narcotics. I had also suffered from depression since I was a child and had been through numerous meds that didn't work or made my life even worse. Tramadol is the only med that I have taken that has successfully treated both my chronic pain as well as my depression, allowing the sun to shine in my life."

10 / 10
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  • obtxn
  • Taken for 1 to 2 years
  • October 6, 2014

"Have taken tramadol in the past. It literally saved my life when I was going through severe depression while slowly recovering from a traumatic injury. My doctor at the time put me on a light dose of tramadol to help with my somber mood. I was alive again. Nowadays, it's virtually impossible to get any doctor to prescribe this. I've tried multiple antidepressants over the last several years and they do nothing for me. Tramadol's the best—for me at least."

10 / 10
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  • sklawz
  • March 26, 2016

"I was first prescribed Tramadol as an add-on drug with my Vicodin due to a serious injury in a car accident. I also suffer from depression and acute anxiety most of my life with panic attacks. The Vicodin worked at first and then made me sick. I would vomit from it sometimes, then it quit working. I took the tramadol once a day usually in the morning and stopped after a month or so because I felt it wasn't doing anything. Man, was I wrong. My injuries healed and I stopped the Vicodin. Upon reading more about Tramadol, I discovered it acts as a Serotonin and Norepinephrine reuptake inhibitor. So it acts as an antidepressant as well as a 'semi-opiate.' Tramadol itself is not an opiate. Your body converts it into one, similar to Nucynta. Great drug."

10 / 10
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  • Anonymous
  • Taken for 5 to 10 years
  • May 13, 2014

"My life was gray on everything, my mood was bad, depressed, and emotional about having to sweep my own floor. I talked to my primary care doctor and asked about tramadol, and he said great things. I now take 6 a day and have been a different person. I now have energy, patience, and I'm a better father who plays with his kids again. Saved my life."

10 / 10
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  • Anonymous
  • Taken for 5 to 10 years
  • September 22, 2012

"I went from one antidepressant to another. SSRIs (multiple), TCAs, SNRIs. Nothing worked and, like others, my moods were up and down the whole time. Twice a day, Tramadol has kept me symptom-free for 5 years now. Amazing."

9 / 10
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151 Report
  • Jason
  • Taken for 6 months to 1 year
  • February 24, 2024

"Initially prescribed Tramadol for lower back pain. Had previously been on other forms of antidepressants for PTSD after a long military and police career. Tramadol worked wonders in alleviating all forms of depressive/anxious thoughts and feelings. I had no idea Tramadol could help in this regard and now use it solely for mental health, having discarded all other medications. Like other reviewers here, I believe more attention and research needs to take place to make this drug a frontrunner in mental health medication. I feel confident, social, and my work has improved immensely since using this medicine. I take 100mg per day and no more. My recommendation is to stick to the prescribed dose and avoid alcohol in large quantities. Please keep in mind that the only side effect I have ever experienced is constipation. With that in mind, I changed to a higher fiber diet with plenty of fruit and vegetables and noticed my gut function returned to normal."

10 / 10
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  • KINGS...
  • Taken for 6 months to 1 year
  • June 22, 2016

"A few years back I developed anxiety and depression. Went on the SSRI and hated it. My dr. Then gave me Tramadol for my back and shoulder pain. But I found that it works better for me for my depression and anxiety. After about 30 minutes from taking the pill I start to feel normal again and level headed."

9 / 10
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  • The...
  • Taken for 5 to 10 years
  • September 14, 2023

"Tramadol works for depression! I take 50mg/day and it changes my outlook. Big Pharma is too invested in anti deoressants to allow Tramadol steal the show: with a rating of 9.2/10 on drugs.co., Tramadol is the HIGHEST RATED ANTI DEPRESSANT. In low doses (I take 50mg and on occasion 100mg/day) it's not even addictive. Read the reviews!!! Tramadol helped me after my brother died. It brings more color to an otherwise dull screen. It's almost a crime to not dispense Tramadol for depression!!!"

10 / 10
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  • JYano
  • Taken for 5 to 10 years
  • October 7, 2019

"I love tramadol. I use it for both mood and pain. I usually take 50mg a day but some days none and some days 100mg. I like it because I take as needed. I've been addicted to opioids but this one is different. It's like a miracle drug for me."

10 / 10
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  • Shell...
  • Taken for 1 to 2 years
  • December 21, 2020

"I take tramadol for lower pain, however, I use it mainly for depression and anxiety. It works better than any antidepressant I’ve ever taken. I’m on the 50mg instant release tablets, and I take it up to 4 times a day. I keep my dose between 100mg-200mg a day. I don’t overtake it, as tolerance builds up quickly. In reference to the people who warned that this drug is very addictive, and that it shouldn’t be prescribed for depression because of that, I have to say, regular antidepressants are just as bad if you quit taking them (MAJOR withdrawals, brain zaps, etc) ...so prescribing tramadol shouldn’t be any different. This drug has done wonders for me, and I’m so happy I was able to find a doctor who would write it for me."

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  • Julz
  • Taken for 2 to 5 years
  • October 29, 2018

"I LOVE Tramadol. I'm a stay-at-home mom, and I'm overweight, with a big chest, and my back hurts all the time. Chasing toddlers around and doing housework can be aggravating at times. I've found Tramadol to help with quite a few things: Mood, Motivation, pain, depression. I no longer take Valium and Effexor for my anxiety and depression because Tramadol helps everything in my case! It's a wonder pill for me. I usually take 50mg when I get up, 1 later on in the day, then 1 at night. Sometimes I might take 2 in the morning and then 1 later that evening. But regardless, Tramadol makes me feel normal and able to do my everyday duties without being in a slump. It's a shame it's a narcotic now because doctors are hesitant to prescribe, and you don't get refills, so you have to go every month to your doctor to get it. Hope this helps someone in pain and or depression as I've found it to be of help in both areas!"

10 / 10
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  • Miguel...
  • April 15, 2016

"I was facing several months of on and off depression since being forced to move. I had and have no one to communicate with anymore. The loneliness made me realize how empty my life is and see no purpose in anything. I lost all motivation. The greater issue was that I was starting to feel like this every day and started pondering suicide. I decided to try Tramadol since it was available to me. I took 100 mg to test it and I felt normal again (able to feel pleasure and then some). The experience was amazing and it gave my social confidence I was lacking. As the Tramadol wore off, I was able to speak in a debate group without issue (I usually get nervous and lose track) and it was noticed. I all"

10 / 10
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  • soleto
  • July 17, 2015

"Thumbs up! I was prescribed Tramadol for abdominal pain, and in the process of taking once daily, 50mg, I realized that my energy is boosted, my mood is elevated, and I felt 10 to 15 years younger. I also observed more creativity and a heightened sense of well-being. Must be the serotonin higher levels."

9 / 10
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  • DanDa...
  • Taken for less than 1 month
  • July 2, 2019

"I suffer from MDD and have taken about 7 different antidepressants, which have been, for the most part, ineffective. On the 4 or 5 occasions I have taken tramadol, it has had noticeable effects on my mood. Tramadol doesn't make me drowsy and has powerful antidepressant effects. I feel better for days after a single dose of Tramadol, during which I feel I have more energy, less anxiety, and feel oddly clearheaded. I know this drug is not typically indicated for depression or anxiety, but it seems to crush both in one go, at least for me anyways."

10 / 10
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72 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.