Prucalopride for Chronic Idiopathic Constipation User Reviews (Page 2)

• Oli...
• Taken for 1 to 6 months
• March 3, 2022

Prucalopride "At first, this pill was miraculous. Then I started noticing insomnia and the most vivid nightmares/dreams I've ever had. That progressed to an acute change in my mood. I am normally a very calm person, and I've been in a rage nonstop for no reason. It never occurred to me that it all started when I started this pill. I'm getting off of it and hope things go back to normal. It's not worth it."

• sof...
• Taken for less than 1 month
• May 1, 2020

Prucalopride "Oi! I have been constipated all my life, tried all the OTC stuff. I tried Trulance before this one, did not help at all. I was very hopeful for Motegrity. It worked amazingly the first two days, first times I have ever had a complete bowel movement. I had some bad gas and awful pain in my back and sides. I was also quite achy, almost like I was hungover. Unfortunately, when the pain stopped on the third day, so did the bowel movements. On to the next!"

• Do...
• Taken for 1 to 6 months
• February 15, 2022

Prucalopride "I started taking Motegrity after failing with many other medications following problems with slow gastric motility, recurring SIBO, and chronic constipation. At first, I was taking it every few days because, while effective, it caused cramping and stomachaches. I went back to my GI feeling at a loss because I felt like I’ve tried everything, and she said, of course it’s going to cause cramping if I haven’t had a BM in a week! She recommended cleaning myself out with magnesium citrate for a day, then taking Motegrity daily. This has helped! I’ve actually had normal BMs for the first time in a long time!"

• Don...
• Taken for less than 1 month
• October 4, 2021

Prucalopride "I have suffered for years with chronic constipation. I have a diagnosis of gastroparesis and achalasia. Was hoping this would be the miracle medication, but instead, it turned out to be a nightmare. After 5 days, I still did not have a bowel movement. However, I woke up on day 4 crying, which is not normal for me. Day 5, I woke up crying and felt life was no longer worth living. Serious depression occurred with this medication. WARNING! If you take this medication, make sure you monitor your mental health. After stopping Motegrity, I returned to my constipated but happy life."

• Van...
• Taken for 1 to 2 years
• March 3, 2021

Prucalopride "My quality of life has improved drastically on this drug. I had some side effects in the first week (headache mostly), but those resolved. I've tried other drugs (Linzess, Amitiza, Trulance), and they did not help me. I have a tortuous colon. My insurance company recently stopped covering this drug, but the alternatives do not help me."

• Mom...
• Taken for less than 1 month
• February 5, 2021

Prucalopride "Horrific. I took 1 tablet before bedtime and woke up writhing in pain. Strange, loud stomach noises followed by gas of epic proportions, which smelled sickly. Pain all day the next day. I’d rather be constipated, and that’s saying a lot."

• Kal...
• Taken for less than 1 month
• October 8, 2024

Prucalopride "It works!!! First day I took it, I did have a migraine. Following days I got lucky and no migraine. I actually have solid bowel movements and go 2-3x a day. I take it early in the morning. I tried Linzess and Trulance, which caused bloating and watery diarrhea, and I couldn’t leave my house for 4-6 hours. Some days it wouldn’t work and caused more bloating. I highly suggest giving Motegrity a try. It saved me."

• deb...
• Taken for less than 1 month
• March 29, 2024

Prucalopride "Motegrity worked as soon as I started it. It is the only medication that has ever worked, it changed my life. I can eat regularly. I've stopped taking harsh laxatives. I'm regular and comfortable. Best medicine ever!"

• Sab...
• Taken for less than 1 month
• December 9, 2019

Prucalopride "Tried Motegrity and got a horrible headache/migraine, major fatigue (had to take a nap to sleep off the pounding headache), and diarrhea. Not impressed whatsoever. Tired of GI doctors handing out pills like candy, not once has my GI asked me about my diet. I’m switching doctors, this one just doesn’t get it!"

• CFS...
• Taken for less than 1 month
• February 13, 2022

Prucalopride "Love Motegrity! It took only one day to work for me. I was desperate, severe constipation and even ended up in the ED. I felt my current medication had to stop working, so my doctor suggested Motegrity. A real miracle medication for me."

• Kay...
• January 6, 2021

Prucalopride "I took Motegrity one day, and I barely made it through the day. Started with diarrhea and extreme bloating and stomach pains. Then started getting dizzy and head hurting. By that night, I had a pounding headache, could barely stand, running to the bathroom-dizziness-it was awful. I felt so sick I almost went to the ER. Day two, and I still have a lingering headache and diarrhea, stomach pains, and extreme bloating. Never taking this pill again. I must mention I have also tried Linzess and also experienced extreme bloating and diarrhea, but none of these other symptoms."

• Mar...
• Taken for less than 1 month
• January 15, 2022

Prucalopride "I have some pretty severe constipation issues, along with a tortuous colon and some other digestive issues (removed gallbladder, food allergies, etc.). I’ve tried Trulance (didn’t work), Linzess (worked at first but not consistently), along with other OTC methods such as stool softeners and Miralax. It gets bad though, where I have to use an enema to make things move. Since I was still having issues with a complete natural BM, my GI doctor wanted to try Motegrity to “give that extra push.” Within an hour of taking this, I was doubled up in the bathroom with the worst case of vomiting/dry heaving and diarrhea-reminds me of when I had severe food poisoning. I was sweating, head felt tingling and spinning. Y’all, I lost 5 pounds. While I appreciate the cleanout, I will not be taking another dose of this. Btw… this reaction is surprising to me since it took almost a full day for the colonoscopy cleanse to go into effect."

• Lau...
• Taken for less than 1 month
• March 18, 2022

Prucalopride "This drug works well - no urgency, feels very ‘normal’. But gives the most horrible crushing depression. If you have a history of depression, use with extreme caution as this causes extreme suicidal ideation. You should let a close friend/family member know if you plan to take this drug so they can keep an unbiased eye on you."

• Liz...
• Taken for 2 to 5 years
• February 17, 2025

"I have suffered from constipation all my life and recently gave up 4 years after trying all those medicines that you mention, Lisness, Trulance, Ibsrela, Probe, Motegrity, and it was wonderful. There were no side effects every day, but the problem that arose was the insurance that wouldn't cover it, so I spent time without using it because the payment was $800. So recently, in view of the insurance that was charging so much, I decided to opt for prucalopride, which is the component that contains Motegrity and is cheaper. But the first day I took it, I felt terrible, with nausea, headache, and spent all day in bed. I felt bowel movements, but it was so discomforting and also the dry mouth. I was afraid to take it on the 2nd day, and I didn't do it. Then on the fourth day, I dared and took it in the afternoon. That night I slept well, but the next day I felt decayed and with a bitter taste in my mouth. I decided to stop taking it, and I will take it in a few days as advised before bedtime."

• Trg...
• Taken for less than 1 month
• November 27, 2021

Prucalopride "I have suffered with IBS-C for over 40 years, nothing has helped. Last year it got worse, most likely from not moving as much. My stomach was so bloated and hard, I was so sluggish I could barely move, even with laxatives. I finally was approved on insurance, and my doctor gave me samples of Motegrity. Of course, I read the reviews first and was not going to take it, then I thought, what is there to lose? The first day I took it, I felt weird at work and had a headache. Then I came back and read the 'good' reviews, and they lined up with my issues. I confirmed with my doctor that it should be taken on an empty stomach if possible. (NOTE: I also started taking a probiotic, which I think helps.) Well, the heavens have opened in a good way. The bloating is gone, and I am going normally, like honestly, if I ate better, it would be 100%. I am not seeing any side effects that I’m aware of. And this is only $15 on my insurance. Try this, get samples first."

• M Q...
• Taken for less than 1 month
• June 28, 2023

Prucalopride "I'm so glad I read the reviews and suggestions for Motegrity. I took my first dose in the morning and had such bad side effects, I was ready to just stop taking. Major headache, nausea, and agitation. I saw that starting at half dose and taking it in the evening was beneficial. After a week of half dose in the evening, I started with the full pill. My bad side effects were gone, and I had regular BMs without the diarrhea I had with Linzess. So glad I hung in there! I now have none of the side effects and only the benefits. I hope this continues to work as everything else has been a disappointment."

• Anonymous
• Taken for less than 1 month
• October 15, 2021

Prucalopride "I had a free trial (7 pills) from my GI doctor. I'd never afford this because it's $300 without insurance a month. I took a quarter of a pill for several days of constipation and stomach burning. Within 30 min, I had diarrhea with solids. I haven't had loose stools in over a year, and I was actually pleased not to give birth for once. I didn't have worse cramps than I was already having, and I didn't get a headache like others warned. I only weigh 120 lb, and I saw others say they had better success with smaller doses. I can say this medicine works way better than OTC stool softeners I've used if you need an immediate BM."

• Mkm...
• Taken for 2 to 5 years
• April 23, 2023

Prucalopride "My previous GI put me on this 3 yrs ago, and it was very effective - so effective that I had to start out at a lower dose by cutting it in half. After a while, it seems like it was the worst depression that I had at the time. So I started taking it at night, which reduced that side effect, but it started to seem a little less effective, maybe coincidental. Eventually, I moved it back to daytime to see if it would be more effective, and my mood was fine with it - it didn't seem to have any effect on my mood anymore, fortunately, but within a year, it seemed like it stopped working. Just from personal experience, I suggest that anyone who feels this works really well but is finding mood problems with it try to treat their depression more effectively in other ways to see if they can tolerate this med. As I said, eventually, it stopped working. I feel for everyone on here. This is a very uncomfortable and frustrating condition. Hoping all of you find your solution."

• Ful...
• April 16, 2021

Prucalopride "I have chronic constipation, and it's absolutely a life of misery. My doctor prescribed Motegrity, and it works. However, the horrific cramps and headache I could do without. The warning sign that I need to stay put close to a bathroom are the cramps and nausea. The headache starts about 30 minutes after taking it. When you live with idiopathic chronic constipation as severely as I do, then you kind of have to go with what works. Nevertheless, I could definitely live without the side effects."

• Kok...
• Taken for less than 1 month
• March 15, 2021

Prucalopride "I took just a 1/2 yesterday morning. Got a crazy pounding headache within 10 minutes, then was constantly going to the bathroom. Nauseated and pounding heart. I have postural tachycardia syndrome and was flaring with adrenaline surges after taking this 1/2 once. It said it lasts 24 hours. Nope, it’s been 36 hours, and I’m still feeling sick to my stomach and nauseated. I could just sip my water. I am trying to push Gatorade as I’m dehydrated. I’ve been massaging my stomach as it’s in pain and gurgling still! I guess I’ll stick to Miralax in my water and stool softeners. This is not for me!"

• Kar...
• Taken for less than 1 month
• February 1, 2022

Prucalopride "I’m looking for personal experiences… Does taking this medication, day 1 hour before the first meal of the day, work better than taking Motegrity with food? I’ve been taking it on an empty stomach in the AM. The good response for me is no belly ache all night long."

• Lin...
• Taken for less than 1 month
• November 9, 2019

"I thought when this came out this was going to be my hope. Unfortunately, it didn’t work. After two weeks, I had to take citrate of magnesia to empty out. This medication is horrible and causes awful, painful gas and depressed mood. My gastroenterologists refused to give me Zelnorm because I have controlled palpitations. No heart disease, she said it would work. So my last option is colon removal because I can’t live like this anymore, using Dulcolax and bowel preps every three days."

• Kat...
• Taken for 6 months to 1 year
• March 14, 2020

"After trying senna, stool softeners, Citrucel, Miralax, and Linzess, my doctor suggested Motegrity. I’ve been taking it for months. For me, it is a miracle drug. I almost forget I have a problem without it!"

• Ell...
• Taken for 1 to 6 months
• February 17, 2020

"I have been on Motegrity for 6 weeks, and I am having normal BMs. At about 4 weeks, I started experiencing fatigue, which has become worse. I stopped taking the med this morning, and by 3 PM, the fatigue had lifted. Has anybody else had this side effect? Is it transient?"

• Rel...
• Taken for 1 to 2 years
• August 24, 2020

"I finally broke down and started taking 2 mg prucalopride every evening. I have tried everything natural for 25 years; fruits and veggies (live on spinach), a gallon of water a day, exercise, flaxseed (worked for a while), probiotics (also worked for a while and then you need more and more), and psyllium. Now, I supplement the 2 mg with probiotics and psyllium, and I go every day. I feel bad depending on something so strong. I hope it’s not bad for us?!"