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Progesterone for Perimenopausal Symptoms User Reviews

Brand names: Prometrium, Endometrin, Crinone, Cyclogest, Gestone, First Progesterone MC10 First Progesterone MC5 Milprosa

Rating: 5.9

Progesterone has an average rating of 5.9 out of 10 from a total of 18 reviews for the treatment of perimenopausal symptoms. 33% of reviewers reported a positive experience, while 22% reported a negative experience.

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Reviews for Progesterone

  • Mis...
  • Taken for 1 to 6 months
  • July 12, 2018

Progesterone "I’m 46, perimenopausal, regular periods. I had very bad PMS and sore breasts for 2 weeks before period, and a serious inability to lose weight. I started this 3 months ago and I’m down 8 pounds, sleeping better and PMS is way better although it took the full 3 months for it to start helping. Now weighing 140 pounds at 5’7. I was very worried about weight gain on this, but it was opposite for me! I take 100mg at bedtime and stop it for 7 days during my period. I also started on Estro support (DIM) to lower estrogen as well. That also made a huge difference! Get your hormones tested so you know exactly what’s going on in your body!"

10 / 10
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  • Dan...
  • Taken for less than 1 month
  • May 2, 2020

Progesterone "After 8 days on this medication, I was having full-blown panic attacks. I was on 200 mg daily. This is a horrible side effect, just want people to know about. It may not do that to everyone, but if you have ever had anxiety in the past, be careful on your dosage."

4 / 10
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123 Report
  • Lor...
  • April 22, 2012

"I am soon to be 49 and I was feeling so bad, hot flashes, 30 pounds of weight gain in 2 years, insomnia, foggy brain and a very large appetite, to name a few. But I saw a doctor (alternative) and he did blood work and found my testosterone was so low and my progesterone. So I now take a small dose of testosterone cream and 200 mg of natural progesterone. Can I tell you I feel like I did in my 30s. Use progesterone at night, testosterone in the morning. I have lost 12 pounds in about 40 days and it continues to fall off. Sleeping like a baby, no hot flashes and I think more clearly and my memory is awesome too. I do take a lot of supplements that work with the hormones."

10 / 10
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200 Report

Frequently asked questions

  • Ms ...
  • Taken for less than 1 month
  • June 4, 2013

"I am a 51-year-old woman diagnosed with fibroids and have experienced very heavy bleeding. With the added issue of the pre-menopausal symptoms, I felt like I was losing my mind. I have been taking progesterone 200mg for about a week, and I haven't felt this good in years. No more cloudy head, joint pains, and night sweats are almost gone. The best part is I'm not craving junk food and sweets. So far, so good, no weird side effects. This is the best!"

9 / 10
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  • kbe...
  • November 12, 2010

Progesterone "Taking it at 100 mg. Didn't like the dizzy feeling. Started taking it at night, much better, but I feel it building up in my system over time. I wish I could take half or 3/4 as much, but it is not available in those doses. I have absorption issues, and the liquid form is great except I can't cut it in half. I do like what it does for my thinking, digestion, emotions, etc., but over time, irritability, heavy dreaming, pregnant-like feeling build up. I am a small woman, about 110 lbs, 5 feet, and wish smaller doses were available. A little bit goes a long way."

7 / 10
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  • Bea...
  • December 23, 2016

Progesterone "I'm 42 years old and perimenopause has taken over my life. My estrogen dominance was so bad that for 8 whole days before I even started my period, I was almost bedridden. My breasts were so sore, it was as if they were engorged, and I, at times, felt a low-grade fever coming on. I have a 21-day cycle. I have one week a month that I felt pretty OK... Only one week a month!! Went to the OBGYN and begged for help. I'm now on day 5 of Prometrium. So far, my head is clear, no boob pain, I'm awake not tired, not hungry either. I do have some uterine cramps every afternoon for some reason. I can't wait to see how my whole cycle will be. So far so good, very happy."

7 / 10
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98 Report
  • SL2...
  • Taken for less than 1 month
  • June 12, 2022

Progesterone "I tried taking 100 mg of Prometrium daily for 3 days after entering menopause at age 51. I have not had a period in almost 1 year. It is awful stuff. It immediately gave me a horrible dull headache, a sense of depression, and a feeling of malaise. I'll stick with natural remedies for hot flashes, which Prometrium also made worse, frankly. It is also worth noting that I have never taken birth control or any other hormone supplements."

1 / 10
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41 Report

More FAQ

  • Ste...
  • Taken for 1 to 6 months
  • August 2, 2020

Progesterone "I started taking 200 mg day 14-28 of my cycle. My doctor had me combine it with a progesterone cream. My breasts became bigger and much more tender. I began steadily gaining weight, up 7 lbs now. I am going to go off the Prometrium and go back to the cream only and see if the sore breasts and weight gain subside. The cream worked well for me in the past, not sure why my doctor felt I needed both the cream and the pill. I do feel progesterone is wonderful for reducing mood swings and food cravings. That issue is all but abolished when I'm on the progesterones, I just am obviously not a fan of the weight gain. So if the goal of the medicine is to increase progesterone levels and decrease mood swings, it is effective."

6 / 10
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  • Jin...
  • Taken for 1 to 6 months
  • March 6, 2022

"First, I tried oral Prometrium and had an awful experience. Very drowsy the next day, extremely vivid dreams, and within two weeks, I was depressed. Switched to vaginal Prometrium, and at first, everything was fine. Then I started having panic attacks and high anxiety. I had labs drawn after I missed a few periods, my FSH was suppressed and my progesterone too high. Needless to say, I must talk to my Dr. about the dose. I never thought progesterone could make you anxious, but it has been awful for me. My progesterone levels were fine for my age in peri-menopause-now I have the progesterone levels of a woman trying to conceive! If you do need to take it, take it vaginally, not orally! The metabolites can make you feel awful, foggy, and out of it, but vaginally, no issue. Except in my case with the problems of anxiety and suppression of FSH and periods."

6 / 10
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  • Dee...
  • October 21, 2019

"HRT has been a Godsend for me. I was recently diagnosed with Polycystic Ovary Syndrome (PCOS). Experienced very painful abdominal discomfort monthly and had very few cycles. HRT was recommended as a low-risk starting point for treatment. I sought an all-natural organic product that was easy to incorporate into my daily routine. After much research, a friend suggested a product, and I am feeling better than I have in a really long time. I am using a cream on certain days of my cycle each month, and the pain has subsided, and my cycle has regulated itself. I am 54 and in perimenopause, and the symptoms of this are minimal as well. I am more than pleased with this treatment and highly recommend it as a low side effect starting point. Using a product that contains a therapeutic amount of progesterone is important for maximum benefit. I am hoping I found a long-term solution because I feel so much relief and comfort each month using this HRT cream."

10 / 10
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  • kat...
  • June 17, 2019

"Does anyone else have a problem taking the 100 mg (red, round gel ball) capsule made by Akorn Inc? I find the capsule keeps sticking to the sides of my throat. It really bothers me, so I am going to see if there is another brand."

4 / 10
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  • Cyb...
  • Taken for less than 1 month
  • December 1, 2020

"I got a hormone test and have low progesterone and high estrogen. I am 48 years young. My new menopause doctor put me on 100 mg of progesterone, but I didn't like the side effects. I was really tired, and my period started up again. I went off it and feel better. I think I am going natural because I don't think there is a medical reason for taking this. I'm afraid to tell my doctor because I was pressured into it. Nine years ago, I took a Depo shot, 15 mins later, I fell on my knees on the sidewalk in NYC in a skirt and couldn't stand up for 20 mins. A group of Dominican men called an ambulance for me. The EMS gave me water, and I went home. I proceeded to bleed for 3 months after. They also had to give me calcium because it caused bone loss. I'm not saying this is the same, but it is progesterone, and unless I have a life-threatening illness that requires hormone replacement, I think I'm going natural."

1 / 10
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24 Report
  • 617...
  • September 24, 2017

"I take progesterone 100 mg once a day and estradiol 1 mg once a day. I have bad headaches and start bleeding again when my period stopped almost 2 years ago. My hot flashes slowed down but are still there. Am I supposed to do these things? I need to know more from someone who takes those meds."

5 / 10
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  • MDD...
  • Taken for 1 to 6 months
  • December 13, 2021

"The neurologist wanted me to consult with a menopause expert to consider HRT. She declined. Estrogen hormone replacement therapy is contraindicated, as I have liver problems, migraines with aura (newer research busted that myth), and a family history of stroke. Nine months ago, I started having hot flashes every day around 2 pm for 3 hours. Intense long flashes, then chills, nausea, migraine attack. Brutal! Couldn’t work, couldn’t go out without a change of clothes and hair ties! New GYN started me on low-dose progesterone (Incassia). Unbelievable difference. Hot flashes are lesser, shorter, but vary in time."

8 / 10
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  • Loi...
  • Taken for less than 1 month
  • November 10, 2020

"This medicine smells strongly chemical and made me bleed for weeks. I had to switch to Dr. Reddy's brand. Would not recommend. 200 mg I had to pay $100 out of my own money because my insurance had already paid for this one. But I really didn't like it so much, I paid for the Dr. Reddy’s."

1 / 10
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  • San...
  • Taken for 1 to 2 years
  • April 21, 2025

Progesterone "The effect of Prometrium for perimenopausal symptoms alongside application of Estrogel is as intended. I am a shift worker who had to get clarification from a second doctor as to when to take on a 24/7 rotating roster. My biggest problem is swallowing the capsule, I have never had problems swallowing anything, but the capsule more often than not is hard to swallow and seems to make its way back up my esophagus, causing discomfort. I now have to take it well before bedtime and drink up to 2 liters of water to avoid the feeling of this well into the night. After Googling this problem, I have found many posts describing the same problem."

7 / 10
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  • Fem...
  • Taken for less than 1 month
  • October 2, 2020

Progesterone "I developed severe tinnitus, and after 1 week, couldn't take generic progesterone for Prometrium anymore."

1 / 10
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18 Report
  • Anonymous
  • May 18, 2011

Progesterone "I take this medicine in conjunction with applications of Divigel."

9 / 10
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18 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.