Olanzapine for Major Depressive Disorder User Reviews (Page 2)

Brand names: Zyprexa, Zyprexa Zydis, Zyprexa Relprevv, Zyprexa Intramuscular

Olanzapine has an average rating of 5.6 out of 10 from a total of 49 reviews for the treatment of Major Depressive Disorder. 45% of reviewers reported a positive experience, while 43% reported a negative experience.

Reviews for Olanzapine

Billy...
May 19, 2015

"I have been taking this in combination with Citalopram 40mg for about 7 years. This drug controlled my racing thoughts and allowed me to sleep properly. My initial dose was 7.5mg but I am now down to 2.5mg. For me now it feels that 7.5mg was a very strong dose but I needed it at the time. I had no negative side effects. No withdrawal on reducing dosage. I don't suffer undue hunger - actually for me my depression contributed to a lack of appetite so any effect was actually beneficial to me. For me it worked wonders and enabled me to work. I think with all these drugs there are different effects on different people and each person is also suffering a unique conditions. I was lucky in that my doctor hit on the right combination for me day 1"

10 / 10

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18 Report

beedo...
Taken for 1 to 2 years
November 2, 2015

"I just got off of this medication after taking it for 1 yr. Sure it keeps depression at bay, but I experienced some horrible side effects that my doctor didn't even warn me about! I gained 80 lbs in 1 yr on this med. I went from being a healthy 170 lbs (women's size 12) to a lethargic 250 lbs (size 20). All I wanted to do on this medicine was eat. Another side effect was that I was tired all the time. I would sleep for 14 hours and still be tired.This medication also raised my blood sugar and my general practitioner was ready to put me on medication for type 2 diabetes. I'm only 25 and just want to be healthy again. So glad I got off this medication. Been off it for 5 days (now on Viibryd) and already feel a million percent better!"

2 / 10

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17 Report

Delta
Taken for less than 1 month
May 10, 2016

"I suffer from depression, anxiety, irritability and anger. I recently fell into a deep depression, was suicidal, and began cutting myself. I was admitted to a psych ward for 4 days, and was prescribed 5mg olanzepine, and my fluoxetine was reduced to 10mg from 30. I'm doing SO much better with this combination. I'm not as anxious as I used to be. My depression is about gone completely, and I'm more patient with society. I've been on it for 2 weeks. The only down side is that I am STARVING, ALL THE TIME. No food can satisfy my stomach. I'm 6' and 150lb, so I don't care if I gain weight, but my mom has type II diabetes, so I'm paranoid taking this medication, which doesn't help my situation"

8 / 10

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16 Report

ndinmi
Taken for 1 to 6 months
January 11, 2024

"I've been very happy with having this added to my antidepressant. My doc put me on a low dose early last month because my depression wasn't fully lifting...and I feel better than I have in at least the last couple of years. I'm actually able to get things done and I feel overall better."

10 / 10

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2 Report

Kmotion
October 4, 2016

Zyprexa (olanzapine) "Prescribed Zyprexa after taking Duloxetine/Cymbalta made me suicidal. It did mellow my mood, helped me gain back the 30 lbs I had lost during height of illness. Hated the inability to laugh or cry. Hated the dry mouth. As a dancer the stiff, dry joints were dangerous. I hurt my knee because the extreme change in my flexibility. Took it for 3 months."

3 / 10

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15 Report

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Jezebel
Taken for less than 1 month
March 20, 2020

"10mg of this olanzapine per day plus 20mg Prozac has made a huge difference. Less anxiety, less depression, only side effect has been tiredness but that’s only a small price to pay! Wonderful and wish I’d tried it before"

9 / 10

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8 Report

Zandieh
Taken for 1 to 6 months
March 4, 2022

"Typical antipsychotic, makes you sleep, gain weight, and suffer from sexual side effects. Disconnects you from all emotions and you walk around like a zombie. This one though, has the added effect of DOUBLE the weight gain. My girlfriend gained 45 pounds in 4 months on this. All Atypicals should just be gone as far as I'm concerned. They should only be used for people with serious psychosis, delusions and hallucinations. Doctors are giving them to everyone because they know SSRIs fail more than half the time and they will do anything to avoid giving a benzo because they care only about their license and stopped caring about the patients. Signed and attested by me, a psychiatrist myself that specializes in mood disorder and addiction. Plot twist. We don't like giving it as much as you don't like taking it!"

2 / 10

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5 Report

stefa...
May 30, 2021

"I have been diagnosed with F33.1 (Major depressive disorder, recurrent, moderate) and F60.3 (Borderline personality disorder) as my secondary diagnosis. My treatment plan included the following: - Olanzapine (0-0-1) 5mg - Venlafaxine (1-0-0) 75mg - Valproic Acid (1-0-1) 250mg It did almost immediately relieve my symptoms. However, the treatment had several side effects that were debilitating and have led me and my psychiatrist to discontinue olanzapine as an adjuvant: - Loss of ability to concentrate. I work as a senior java developer in charge of my own projects, and using olanzapine has led me to stutter and forget words during meetings, unable to keep conversations or explain my recommendations to my clients. - Sleeping 12-14 hours a day. While I did have a normal night's sleep, i wasn't able to keep up an activity for more than 30 mins. - Minor movement issues. I sometimes had lip tremors, especially while having facial expressions."

6 / 10

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6 Report

Anony...
Taken for less than 1 month
July 15, 2018

"I am opioid dependant for nearly 5 years. Subs and Methadone are the medications I rotate, never together. Since starting Zyprexa 2 weeks ago, my worries, agitation and depression have gone. My medication is the following; 80mg methadone daily. (mornings) 15mg Mirtazapine before bed. 5mg wafer Zyprexa mid-afternoon. Only since adding Zyprexa have all my worries and depression been absolved. Incredible medication. In a wafer lollie. If you are opioid dependant like me, suboxone or methadone and you still feel a bit off. SSRIs are not working. Talk to your doctor about Zyprexa wafers. People worry about weight gain on Zyprexa. But a calorie is a calorie. FASTING you'll be Okay. Food cravings have not really increased. Fast Fast in the mornings and you will be fine. Balanced diet after lunchtime and youll be fine."

10 / 10

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8 Report

Kim
Taken for 1 to 6 months
November 8, 2022

"THIS DRUG IS THE WORST! Please, if your Dr. has prescribed this drug try to find something else with Dr’s assistance. I got on Olanzapine and within two weeks I felt like a zombie and could barely keep my eyes awake to drive my children to school (none of the coffee or energy drinks I downed all day worked). I started craving sweets and carbs like a fiend. I couldn’t not eat them. I am typically a balanced and disciplined eater. Within six wks I gained 10lbs. I told my dr I had to get off this drug. I was on a small dose and tapered off quickly. I immediately began waking up with such extreme panic I thought I could die. It was one of the worst feelings I have ever had physically. The only way to “survive” this was to take another drug that knocked me out and sleep through the panic till the afternoon. Not only that my depression came back with a fury. And my fatigue was so intense most days I got back in bed to sleep for hrs. This all lasted 2-3 months."

1 / 10

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3 Report

Nitab...
April 6, 2015

"I just started taking the drug olanzapine. However I having problems with rapid weight gain.. In only 6 days of taking the drug, I have gained 6 pounds. Tomorrow, I'm starting to exercise at least 20 minutes a day. Mentally, I am feeling much better. I am currently taking 5 mgs of Olanzapine along with 40 mgs of Fluoxetine once daily for major depressive disorder. I know this medication is working because I am willing to exercise. So far, so good."

9 / 10

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11 Report

Sergi...
August 5, 2022

"I was prescribed olanzapine as an adjuvant to a major depressive episode along with Trazodone. I had taken it before during another depressive episode along with Cymbalta (Duloxetine). I was on either 5 or 10 mg. On both occasions it caused me akathisia (a feeling of being unable to stand still, move constantly, internal restlessness and even suicide thoughts. If anything, it made my depression worse. I’m on the course of removing it from my treatment plan. Hope the akathisia will go away as it did in the past."

1 / 10

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1 Report

Dope
Taken for 6 months to 1 year
October 21, 2023

"Hey, I've been diagnosed with psychosis and major depressive disorder. I got prescribed olanzapine in January. It was the only antipsychotic that didn't make me want to kill myself after increasing the dose. It made me numb to just about everything and I gained 28 pounds. However, it did cure my psychotic symptoms. I notice a lack of energy in my personality. I find it harder to socialize with people, but I'm not sure if it's because of anxiety or if it is actually the olanzapine making me slower."

7 / 10

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0 Report

mcdou...
Taken for less than 1 month
October 13, 2016

Zyprexa (olanzapine) "after 4 weeks on this medication my partner of 18 years a 35 year old man died from its side effects"

1 / 10

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31 Report

Katjo
Taken for 2 to 5 years
October 30, 2017

Zyprexa (olanzapine) "This taken with Zoloft helped me tremendously with my mdd, ptsd and ocd. Did gain some weight this last time taking it, but mentally feel 98% better"

10 / 10

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23 Report

Betty...
February 7, 2021

Zyprexa (olanzapine) "This medicine made my mom go into a seizure that lead to her death- stay away from this drug!"

1 / 10

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13 Report

Zyprex
November 12, 2019

Zyprexa Zydis (olanzapine) "Zyprexa Zydis helped a lot with anger and rage, still have episodes but less often and a shorter duration. Weight gain is a problem."

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16 Report

Mecrazy
March 10, 2015

Zyprexa (olanzapine) "I gained 100 lbs but slept well and felt mentally ok"

10 / 10

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23 Report

Tano
Taken for 6 months to 1 year
August 2, 2021

Zyprexa (olanzapine) "This drug saved my life. Helped immediately when I was going through a separation"

10 / 10

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7 Report

Angie
Taken for 2 to 5 years
August 11, 2020

"I love Olanzapine. It's a great med. The only downside is weight gain. I have gained 35 kilos since being on it. Very good for agitation and bipolar disorder. I am on 30 MG's a day"

8 / 10

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8 Report

JJano
Taken for 5 to 10 years
January 31, 2020

Zyprexa Zydis (olanzapine) "I take it for anxiety and it helps calm me down. I prefer the Zydis. it is fast acting."

8 / 10

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8 Report

mindy
Taken for less than 1 month
November 3, 2022

Zyprexa (olanzapine) "It made me sick, made me have a horrible gut pain and spent a 24 hour period vomiting stomach acid. I had to go to two different ERs and get a cat scan bc morphine wouldn't even touch the gut pain."

1 / 10

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4 Report

AJO
Taken for 1 to 6 months
June 29, 2019

"This medicine literally makes you zero IQ. I'd rather take Risperidone which ruins my libido than having zero IQ."

1 / 10

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8 Report

Mahmoud
May 11, 2021

Zyprexa (olanzapine) "it's a good medicine, I feel me again during one week ! Sure I have gained weight but it is worth it as my depression and anxiety are more under control"

7 / 10

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5 Report

Dibdo
Taken for less than 1 month
October 31, 2016

Zyprexa (olanzapine) "Amazing drug ! Love it ."

10 / 10

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10 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.