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Levomilnacipran for Major Depressive Disorder User Reviews (Page 4)

Brand names: Fetzima

Levomilnacipran has an average rating of 5.3 out of 10 from a total of 108 reviews for the treatment of Major Depressive Disorder. 39% of reviewers reported a positive experience, while 42% reported a negative experience.

Reviews for Levomilnacipran

  • somet...
  • Taken for less than 1 month
  • June 8, 2015

Fetzima (levomilnacipran) "Took Fetzima 40mg for first time last night, kept waking up all night, horrible gas, woke in the morning(5am) and had to throw up, also had excessive sweating, headache, overall sour stomach. Will not continue taking medication, have never had such a bad reaction to antidepressant before today."

1 / 10
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  • goofy...
  • August 26, 2020

Fetzima (levomilnacipran) "Mixed feelings. Took a while for Fetzima to take effect, I was very nauseous. It helped some with moving on from anxiety, and I didn't have the bad nightmares I had on other medication (my sleep has actually been really excellent).I felt more motivated and stable on good days. As for depression, it helped some. It's hard to say as it's 2020 and I've had physical health issues. Main concern- it might have caused elevated heart rate/abnormal bp I experienced on dose of 80 mg. This may be due to my thyroid disease. I am switching off of it due to this and concerns of how expensive it is. I wouldn't recommend it unless you have good insurance and check cost of co-pay. I didn't have the huge appetite that I've experienced on other meds. I think side effects were limited. I'd consider going back on this in the future if it weren't for the $ and worries about tachycardia. It's definitely better than many I've tried-that list is ever approaching 30. Good luck to everyone w med change in this pandemic!"

7 / 10
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  • Lisa4...
  • Taken for 1 to 6 months
  • July 22, 2016

Fetzima (levomilnacipran) "I have had depression for about 13 years know or I guess it started out as anxiety. I have been on every medication you can name. Most had side effects and had to be switched but nothing serious. I was on Celexa for about ten years and then about three years ago it just stopped working. That is when I was diagnosed with major depression. I don't have a marriage anymore after twenty-two years, lost my job after nine years, can hardly get out of bed most days. I'm not living living, I'm serviving. My doctor put my on Fetzima and after not seeing any improvement at 40mg he moved me up to 80mg. I started not being able to urinate without forcing it out and had to go every two hours. I have never had bladder problems before. I got off the pills"

3 / 10
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Frequently asked questions

  • fullh...
  • Taken for 1 to 6 months
  • January 15, 2020

Fetzima (levomilnacipran) "This medication Fetzima was given to me in sample boxes by my doctor. The starting dose was 20mg for a week then went up to 40mg. After a few weeks on 40mg I found myself feeling suicidal. I tapered down to 20mg but there was not enough samples left for a full taper. My doctor went on giving me a prescription for 20mg of fetzima for 30 days and the cost was $150. I was shocked, it's not covered by most benefits and I couldn't afford the 150$ a month on top of my other bills. I I've tried a series of medications and have yet to find ones that work. the only ones that have seemed to helped a bit have been prozac and effexor."

1 / 10
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  • Anonymous
  • Taken for 5 to 10 years
  • January 19, 2023

Fetzima (levomilnacipran) "I have taken everything since my son was born in 1997. Had no problems before then. I had just gone through TMS treatments in 2015 and switched to Fetzima. This was the most anxious I have been on any med. After 2 weeks I went from 40 to 20mg. I took it at night. I had no problems. It helped my depression at a low dose. I think I am one of maybe 10 people that can take it. The problem is I just got married and when I switched insurances they did not want to pay. So my doctor and I decided to switch to Cymbalta 30. It was an easy switch until the Cymbalta kicked in. It was like going from energized to popping sleeping pills all day. I had to switch from Cymbalta to Wellbutrin. Fetzima is very hard to get past the anxiety in the beginning but I took it for 7 years with no problems. I was told the med did not pick up like expected and wasn’t sure if there would be a generic. The only negative thing I can say is most of these drugs cause emotional blunting."

9 / 10
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Are you taking this medicine?

  • Map
  • Taken for 6 months to 1 year
  • September 4, 2015

Fetzima (levomilnacipran) "Developed condition of depressive ice disorder that I couldn't even get out of bed - odd for type A person of high activity but doctors decided it was a form or norepinephrine depression related to high dose and bad reaction to fludrocortisone I had to take fetzima was only medicine of 13 tried to have sufficient efficacy. It was truly amazing that chemical imbalance can result in this inertia. However... Early on jitteriness nausea, insomnia, irritability, lower anxiety threshold made me wonder if this was a good decision.... After 9 months. Efficacy there- good enough for me to do the heavy lifting to get myself into new habits, new social situations, etc. irritability itself waned, sleep problems continued, causing more problems"

5 / 10
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  • Tmg4me
  • Taken for less than 1 month
  • November 26, 2017

Fetzima (levomilnacipran) "The three days that I took this medication for my depression I had a horrible experience. I felt as though the Medicine turned me into someone that I didn't recognize. I became so angry and irate that I could rip someones head off. I couldn't control my feelings. Crying, Sadness, Angry and felt like I was Manic. I even quit my Job. My life is now ruined."

1 / 10
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  • Pms
  • September 5, 2015

Fetzima (levomilnacipran) "Not that great of a drug! I am finally off of it and can say it was terrible. It worked ok in the beginning but it made me so unstable and miserable. Another drawback was the any small amount of alcohol would leave me feeling out of control. I'm off of everything and feeling great mentally. I suffer from neuropathy, anxiety and depression but I think the depression and anxiety came from the Fetzima. Dr game me cymbalta 60 which was too much (bad reaction) so I'm going to try 30 Mg for my pain and neuropathy to see what happens."

1 / 10
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  • Very...
  • April 20, 2018

Fetzima (levomilnacipran) "I'm on lamotrigine and as unsure as it could be my own reaction. I suffered horrible symptoms for 3 weeks - migraines that lasted for literally 2 weeks straight - Eye pain (I do have glaucoma) - Upset stomach - Once vomited - After coming off severe violent mood swings leading to outbursts - Neck pain back pain which on week 4 has not gone away yet -Muscle pain -Muscle flinching as if my brain was giving shock through body -Severe confusion to the point I couldn't tell what happened and didn't really happen -Weakness to the point I could hardly get up -Seveer chest pain -Always out of breath -Sore nose as if stinging -Blurry eyes -Watery and burning eyes -Broken sleep -Thoughts of losing sanity -Weight gain -Out of control hunger -Chills -Sweats -Shaking -Shivering -Difficulty warming up This was only 2 weeks by week 4 I'm only now starting to feel better."

2 / 10
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  • PillB...
  • January 26, 2018

Fetzima (levomilnacipran) "I took Fetzima for about 8 or 9 months for a bout of depression I had. Unlike other anti-depressants that I had tried in the past, this medicine took a really long time to kick in. I would say I didn't get better in my depression until about 3 months after taking. And Fetzima did work. However, not without side effects. Most particularly the sexual side effects and what seemed like some type of problem cutting off my urination. I'm a guy by the way. All in all, it did work and helped me feel better. But after nearly 9 months of it, the side effects became to bothersome so I switched off. I wouldn't go back on it again unless I was completely desperate."

7 / 10
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  • Emera
  • Taken for 1 to 6 months
  • March 23, 2021

Fetzima (levomilnacipran) "I've been on this medication for approx a month now. Sleeping a bit better, thoughts are a bit clearer BUT I feel so angry and aggressive. Anxiety is through the roof, and its making my home/work life a pure nightmare. I feel nauseous most mornings and a couple times my chest became very tight with excessive sweating. Its early but so far not impressed at all."

2 / 10
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  • WaveG...
  • Taken for less than 1 month
  • June 27, 2016

Fetzima (levomilnacipran) "I'm not sure about Fetzima's effectiveness as I'm on day four of treatment. As for side effects, I noticed that I started sweating more on day 3 (40 MG), a lack of appetite, and some minor nausea. Occasionally I'll get anxious, but I'm not sure if it's specific to the Fetzima or my general anxiety."

6 / 10
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  • SJd
  • Taken for 1 to 6 months
  • December 19, 2022

Fetzima (levomilnacipran) "I’ve been on Fetzima 80mg for 4 months now. It is awful. It did improve my mood initially but that was short-lived. Now, the depression is back with an extra boost of irritability and anxiety. The worse side effects, however, are (extreme) difficulty urinating, non-existent libido and trouble concentrating."

2 / 10
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  • Nitro
  • Taken for 2 to 5 years
  • August 2, 2022

Fetzima (levomilnacipran) "The worst drug I have ever taken, and I have taken at least 50. Caused extreme anger/rage outbursts over simple things. It jacked my heart up 45 beats, I was having serious AFib. Not to mention after four years I have never experienced a drug this physically addicting. More physical and intense withdrawals than coming off Benzos by far intense stomach pain, nausea, vomiting, migraine, dizzy just feel horrible and this is a taper. This medicine turned me into a very scary human being, and discontinuing it is just as scary. Don't take this medicine if you do, be prepared to deal with insane rage."

1 / 10
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  • rojasvi
  • Taken for less than 1 month
  • May 9, 2022

Fetzima (levomilnacipran) "Tried Fetzima after trying several other antidepressants (prozac, lexapro, zoloft, wellbutrin, cymbalta, viibrid, mirtazipine, pristiq, etc). I started on 20mg and unfortunately had to go off due to side effects: high blood pressure, intense headaches, difficulty urinating, random sweating. If it weren’t for the high blood pressure, I would’ve waited out the side effects but I couldn’t handle that. It also reduced my appetite which would’ve been good for weight loss if I stayed on it. I’m probably gonna go back on pristiq. I had hopes for this med but the side effects were too much for me. I also have bad luck when it comes to side effects so."

3 / 10
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  • fetzima...
  • Taken for less than 1 month
  • August 23, 2021

Fetzima (levomilnacipran) "Horrible. My anxiety and depression increased substantially, I lost almost 5 lbs in a week because of the uncontrolled anxiety it so ignorantly gave me. I was crying constantly and unable to sleep due to constant panic attacks during the night. I stopped taking it and have started zoloft about 3 days ago. I want my life back pre fetzima and never ever want to look at this drug again."

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  • G3n3s1s
  • Taken for less than 1 month
  • April 10, 2016

"I started on brintellix titrating up to 20mg, which worked, but made me feel removed and outside of the world. My insurance decided to stop covering it and so we decided to jump medications. I started fetzima 80mg, the equivalent to the brintellix 20mg. I cannot really comment of the side effects as I'm withdrawing from the brintellix. I have excessive sweating, but I'm not sure if it's withdraws or side effects. I'll update in a few weeks. I can say that I feel more energized and happy. My anxiety is gone and I'm hoping in a few weeks I will have adjusted."

3 / 10
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  • Teeters
  • Taken for 2 to 5 years
  • March 3, 2015

"Tried Cymbalta and numerous other anti-depressants. I started Fetzima a sample from my dr. I had started at 80 mg, than I eventually had to be pushed up to 120, mg. This medication is awesome. I do not have any of the side effects talked about above. As a major manic depressed person, this medication has helped so much. I wake up every morning, take my medication and within about an hour or so, I feel so much better. My crying and sorrow has subsided ALOT!!! My depression will always be there with me, but this medication helps alot. I have tried so many different meds. as samples Thank-god for this medication. Works great!"

10 / 10
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  • Megan
  • Taken for 1 to 6 months
  • May 17, 2024

Fetzima (levomilnacipran) "I've been on Fetzima for about 5 months now. At first, it worked well, but my depression started to get worse. Every time they tried to increase my dose, I got serotonin syndrome. They even tried to put me on Seroquel as a supplement, and I ended up in the hospital with serotonin syndrome. I will be requesting to get off of this medication when I see my psychiatrist this week because I can't keep doing this."

2 / 10
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  • bppea...
  • Taken for less than 1 month
  • June 15, 2017

"Was on Fetzima for a week and got Serotonin Syndrome. This is my 5th day off of the med and I am still nauseous, hot, red hot flushed face and chest, body aches and pain. Sweating, chills, goose bumps, constant headache, etc. Ugh, hope it goes away soon, this sucks!!!"

1 / 10
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  • Miaaa
  • Taken for less than 1 month
  • July 16, 2022

Fetzima (levomilnacipran) "I was prescribed Fetzima 20mg ER, yesterday. I have only taken one pill and will never taken one again. I had a heavy onset of "highness" or "altered perception" 30 minutes after taking it (took at 12pm). I was really happy for two hours, then the nausea, headache, and PANIC kicked in. Violently threw up, almost went to the ER because I couldn't breathe from throwing up. Constant stomach pain and inability to eat. Hypertension. I finally fell asleep at 3am to be up at 7am with heart racing and feeling wired again. It's 3pm and I feel like I've had a bad trip on a drug. Never again."

2 / 10
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  • MM1A
  • Taken for 6 months to 1 year
  • October 13, 2023

Fetzima (levomilnacipran) "I took this for almost one year. I had some side effects at the beginning: dry mouth, lost my voice, ringing in ears, stomach pain. These symptoms wore off after a couple of weeks and I started to feel more functional, less anxious, and less reactive. My body aches were also almost gone. I would recommend staying away from alcohol on this medication. Once, I woke up with my heart pounding. It was beating very fast and it was actually scary. I also started to get these painful migraine headaches, a dull headache, and pain behind my eye once or twice a month. I stopped taking it because my insurance was not working for over a week and I could not get it. I decided to just stay off and see how I feel. I do think it improved my quality of life, my focus, and productivity. But I also take Vyvanse, and that helps for now. If I fall back into depression, I would take it again. Even with the side effects."

8 / 10
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  • Vegwe...
  • Taken for 1 to 6 months
  • March 21, 2016

Fetzima (levomilnacipran) "I have had a good experience with increased energy and motivation and decreased muscle pain."

9 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • November 4, 2014

Fetzima (levomilnacipran) "It worked "okay" however the sweating on this medication is way more than I can take. "

1 / 10
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  • Cee
  • Taken for 2 to 5 years
  • June 10, 2019

Fetzima (levomilnacipran) "I have C-PTSD and have tried every antidepressant under the sun, Fetzima is the first that helps with my mental health."

10 / 10
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21 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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