Skip to main content

Levomilnacipran for Depression User Reviews (Page 3)

Brand names: Fetzima

Levomilnacipran has an average rating of 4.9 out of 10 from a total of 96 reviews for the treatment of Depression. 34% of reviewers reported a positive experience, while 47% reported a negative experience.

Reviews for Levomilnacipran

  • Asdfjkl
  • Taken for less than 1 month
  • August 22, 2018

Fetzima (levomilnacipran) "I started on 20mg if Fetzima for one week and am now on second week at 40mg. Fetzima is NOT FOR ME, as side effects thus far include insomnia, major mood swings, uncontrollable crying over ???, tingling of body, heart pounding, muscle aches and redness of eyes, eyelids and skin around eyes. Using my facial lotions—which never bothered me pre-Fetzima—results in a burning sensation on skin. I also have constant ringing in ears, head rushes, and pre-seizure-like auras (I’ve had a few med-related seizures in the past). Feel angry and irritated like never before. I yelled at another driver (not that he could hear or see me), calling him an ** idiot. I rarely swear so this was quite a sign of “me not being me.” THAT SAID, I’m going to speak w/MD and cease further Fetzima intake pronto."

1 / 10
Was this helpful?YesNo
19 Report
  • Scott
  • Taken for 10 years or more
  • May 27, 2019

Fetzima (levomilnacipran) "Tried many antidepressants. SNRI are far superior to all SSRI for my MDD, but at the higher recommended dosages. Effexor XR at 225mg had been the best fairly better than Pristiq and much better than Welbutrin. Won't take Cymbalta or any other hepatic side effects possibilities. Did try in for 6 weeks with no improvement. My insurance covers Fetzima 40mg not much help 80mg vast improvements and 120mg first 2 weeks no difference after that 15 to 20% improvement. Wellbutrin no help. Zoloft importance and no help after 4 weeks so no go. My advice try Effexor XR and don't give up on it until 4 weeks at 225mg. Especially if SSRI aren't working. I had no known side effects at any listed does and been on antidepressants for 17 years"

8 / 10
Was this helpful?YesNo
17 Report
  • sue
  • Taken for 1 to 6 months
  • November 15, 2020

Fetzima (levomilnacipran) "I have had amazing success for depression with Fetzima 80 mg daily of this med. I take it in the morning. The depressive symptoms I was feeling disappeared after less than a week. It is so great to feel back to 'normal' again. I do sweat WAY more, and if I have even a mild alcoholic drink my face gets really flushed and I sweat even more. But it's a great medication for me."

10 / 10
Was this helpful?YesNo
13 Report

Frequently asked questions

  • depee...
  • April 9, 2015

Fetzima (levomilnacipran) "Didn't help my anxiety at all although it does have serotonin in it. However, did help me see reality a bit clearer and begin to feel good emotoons again. Sadly had to get off of it because it caused an allergic reaction after four days with hives and itching. Also made me feel foggy brained, shame after spending $87 on a months worth and having to quit after four days."

6 / 10
Was this helpful?YesNo
26 Report
  • Paulf...
  • November 25, 2016

Fetzima (levomilnacipran) "I too have experienced a lot of loss especially with my divorce. I started up on the Fetzima recently and I'm experiencing fairly persistent symptoms of nausea. I was at 40 mg, but I'm finding that I am having to titrate, because I just can't take the effects of the nausea. I'm trying to stick it out, perhaps go down to 20 mg a day and see where I'm at at this point. I've also tried many medications, and I'm feeling extremely frustrated and somewhat hopeless. Have other people had similar experiences on this medication as far as getting over the hump of nausea? There just doesn't seem to be a lot of options."

1 / 10
Was this helpful?YesNo
22 Report

Are you taking this medicine?

  • Woman
  • Taken for less than 1 month
  • October 23, 2018

Fetzima (levomilnacipran) "Trying this for depression, nothing major, lost my motivation and enjoyment for the usual things. Horrible vomiting a few hours after first 20 mg. Pharmacy says try Gravol with it. Tried it for 12 days, had Chills; my extremities are frozen, feet, nose and hands like blocks of ice. Nausea is debilitating, I felt exhausted 24/7. So I stopped for 5 days to allow the nausea to go away. Tried again after 5 days of break. Day one okay, days 2, 3, 4, and 5 the nausea is back and overwhelming. As soon as I try to get mobile the nausea sets in. Sleep is non existent. I don’t think this drug is for me. Back to the doctor I go."

1 / 10
Was this helpful?YesNo
17 Report
  • Justw...
  • November 10, 2016

Fetzima (levomilnacipran) "I have suffered from hereditary clinical depression for several years. The death of my mother, two loved animals (horse and dog), a divorce that is endless and painful, have all added to my depression, and a new doctor prescribed Fetzima. Now I feel totally insane. My stomach hurts every time I eat; my heart pounds to the point that I wonder if I should go to an ER almost every day; I can't fall asleep and when I do I have stressful nightmares (never had bad dreams before); and every day I feel an anger and rage that makes no sense at all. I have to remind myself to take a deep breath and not act out this new mean personality on my dogs or my friends. No matter what my doctor's opinion, this poison stops tomorrow."

1 / 10
Was this helpful?YesNo
20 Report
  • Batman
  • Taken for less than 1 month
  • April 3, 2017

Fetzima (levomilnacipran) "Age 60 male. Several years with BPH being managed by Xatral but TURP coming soon. Past year my depression/PTSD being managed by Cipralex 20mg. Unhappy with weight gain and anorgasmia so I was just prescribed Fetzima. Weaned off the Cipralex and yesterday was the first day of introduction of Fetzima (20mg) but within hours I developed urinary urgency and much reduced flow. Discomfort increased through the day causing pain and extreme gas/stomach bloating. So 24 hours later I'm not taking Fetzima again until I talk to the doctor. It may just be coincidental but I fear the side effect of urinary retention is a real problem with the Fetzima when exacerbated by a pre-existing BPH condition so beware!"

1 / 10
Was this helpful?YesNo
16 Report
  • brandy...
  • May 29, 2016

Fetzima (levomilnacipran) "spent 3 days only on this. It made me so angry I just wanted to hurt someone, also on day 2 my eyes started twitching off and on all day. stopped taking this on day 4...guess what? 2 months later, my eyes still twitch daily!"

1 / 10
Was this helpful?YesNo
17 Report
  • Redwood
  • Taken for 1 to 6 months
  • November 27, 2018

Fetzima (levomilnacipran) "After about a week, I had extreme sweating, palpitations and testicular pain that would get so bad I walked funny. Was a bit pissed off in general and anxious. Soaked the bed and nightclothes in sweat several times a night."

1 / 10
Was this helpful?YesNo
13 Report
  • sum
  • Taken for 1 to 6 months
  • April 10, 2019

Fetzima (levomilnacipran) "Be careful before deciding to take Fetzima for depression, it is absolutely horrible. Caused me severe vomiting almost every day. The worst part was the way it messed with my brain chemistry. Making me angry, confused, and having severe mood swings. It’s been almost 2 years since I’ve been off this medication and still look back on this medication as a real nightmare. It REALLY makes things worse. DON'T TAKE IT."

1 / 10
Was this helpful?YesNo
12 Report
  • RMH
  • Taken for 1 to 6 months
  • August 27, 2019

Fetzima (levomilnacipran) "It's helping me get through a difficult patch in life. But I thought I had emotional feelings on Fetzima, at first, now I feel like I have none, really, except for my cats. And I'm only taking 10mg, which is opening up a 20mg capsule and taking 1/2 the beads. This stuff should come in a smaller dose like this for chemically sensitive people. So it's OK, but long term I'll probably end up switching to something else."

6 / 10
Was this helpful?YesNo
10 Report
  • There...
  • Taken for 1 to 2 years
  • May 30, 2017

Fetzima (levomilnacipran) "Also wanted to add since I ran out of room on my last post that this medication has also caused me to have SEVERE hot flashes, I'm going through menopause but my hot flashes were not as bad until I started taking fetzima, after I went off of it for 3 months my hot flashes almost vanished, not as severe and not so many and now I've been back on fetzima again for 3 months and HELLO HOT FLASHES, this medication is the worst!!!!!!!!"

1 / 10
Was this helpful?YesNo
12 Report
  • okfitz
  • August 11, 2016

Fetzima (levomilnacipran) "I took this medicine for a few days. The rage I had at all times was so intense it frightened me. It made me have thoughts of hurting others to the point I could not work for fear of hurting people I work with. I had to board my cats to keep from hurting them. I have been off this drug for a year but now when I try other anti depressants the rage seems to come back."

1 / 10
Was this helpful?YesNo
13 Report
  • Alway...
  • August 23, 2017

Fetzima (levomilnacipran) "I tried fetzima for a week going from 20mg to 40mg. I had the worst headaches, chills, and GI problems. I like to exercise and I was afraid I was going to pass out from being so light headed. I stopped taking it, but then changed my mind a month later and went back on. Again, the same side effects even staying on the 20mg. Today will be my last day. I can't live in the bathroom."

1 / 10
Was this helpful?YesNo
11 Report
  • Asdf
  • Taken for 1 to 6 months
  • July 13, 2017

Fetzima (levomilnacipran) "I've taken several different SSRIs and SNRI's. This medication is the worst I have even taken. It makes me feel worse than I felt before I started taking anything at all - sweating, hot flashes, my mouth constantly tastes like I drank salt water, constipated, bloated, nausea, exhausted. You name It. EXTREME RAGE!!!! stay away from this med. it's a scary thing"

1 / 10
Was this helpful?YesNo
11 Report
  • TheXb...
  • Taken for 1 to 6 months
  • January 12, 2021

Fetzima (levomilnacipran) "Was on 20mg for about 6-8 weeks, it worked really well with my anxiety but I stopped it because of the sexual side effects and insomnia. It’s been over a month and I still feel the medicine’s effects on me (positive and negatives) along with discontinuation symptoms (Can’t sleep, nausea, headaches, shaking). It’s truly awful and IDK when I am going to be back to normal."

6 / 10
Was this helpful?YesNo
6 Report
  • iwtste
  • October 26, 2017

Fetzima (levomilnacipran) "After 5 days of 40mg, I jump to the 80mg and almost immediately start have both pain in my testicles as well as very slow urination accompanied by pain as well. The pain would be significant enough to make it hard to sleep at times. This is in addition to the sexual dysfunction, shivers, gastrointestinal problems, and probably other "insignificant" side-effects. This medicine was garbage for me. After 24 hours off the medication, all side effects subside, thank goodness. And on top of all these side effects, it did nothing for my depression."

Was this helpful?YesNo
9 Report
  • Anony...
  • November 2, 2017

Fetzima (levomilnacipran) "I started taking this medication two days ago and have already have a severe reaction to it. I am having severe panic attacks, nausea, body pain, headaches, and I keep uncontrollably crying. It seems as if these are very common side effects and I am basically a walking zombie. I have no emotion, no feeling, and can’t think straight. I wouldn’t recommend this medication to anyone."

Was this helpful?YesNo
9 Report
  • Claire
  • Taken for 10 years or more
  • June 11, 2023

Fetzima (levomilnacipran) "I have been using Fetzima since it first came out. Started with 80 mg, now on 120 mg. This really works for me. It has been the best of at least 10 other prescriptions. I had to go 4 days without because of manufacturing problems. I don't know what to do if a back-order situation happens again. My doctor and I are going to discuss what we should plan if something happens again. I love this product for me."

10 / 10
Was this helpful?YesNo
2 Report
  • anxyus
  • Taken for 6 months to 1 year
  • September 30, 2020

"I was scared to try this because I spent too much time researching people's experiences (and focusing only on the negative). I am so glad I tried it though. For the first time in my life I am actually able to say "I will wait and see what happens and deal with it then" and TRULY mean it. I love this med - no sexual side effects, no weight gain, none of the nausea I had with other drugs. The one issue I've had is higher blood pressure, but it is worth it to add a tiny dose of BP drug along with this."

10 / 10
Was this helpful?YesNo
4 Report
  • rajaa...
  • Taken for 1 to 6 months
  • May 18, 2017

"Im a 35 year old male suffering from Bipolar Disorder, Borderline Personality Disorder, Panic/Anxiety Disorder, and Anoroxia Nervosa. My Bipolar has been extremely resistant to most meds. Ill be okay on a combination of meds for awhile then they stop working. The Bipolar depression would get extremely severe and I've been on dozens of medications over the years without much positive results. After being hospitalized in a very good psychiatric treatment center I was put on a combination of meds that have changed my life. Fetzima was one of them. I've noticed marked improvement in my depression and it has also helped with my anxiety as well (which is great because I no longer need benzodiazepines which were easily abusable). Very happy!"

10 / 10
Was this helpful?YesNo
4 Report
  • Deb
  • Taken for 1 to 2 years
  • December 8, 2015

"I had big anxiety and panic. My doctor gave this to me to treat that even though its for depression. It took about 2 months of treatment to fully see results. I felt 100 % better. Energy alive again. Anxiety was there but more managable. Even I still get "events of anxiety" nothing like before. I must mention my BP was crazy at first with with hot flashes but all the side effects went away"

10 / 10
Was this helpful?YesNo
4 Report
  • Kymmy
  • Taken for less than 1 month
  • July 23, 2014

"My doctor is using this Fetzima for my Fibromyalgia. The Fetzima has made a big difference in my life. I start with 20 mg for 2 days then 40 mg it has help with the pain greatly plus I'm starting to lose weight. My body feels half way normal again. I think the inflammation in my body has gone down also. I don't feel swollen or stiff like I use to. I haven't been using my Tramadol and Ibuprofen much either. I haven't had any side affect at all. My doctor also gave me a coupon that helps. My copay is 50 but with coupon it is 25."

8 / 10
Was this helpful?YesNo
3 Report
  • sotir...
  • Taken for 1 to 2 years
  • March 30, 2022

Fetzima (levomilnacipran) "Started Fetzima 2 years ago when work become overwhelming and I had to take a two-month break. It's the first drug that ever really worked for me and it barely has any side effects. Made me enjoy things again and massively reduced the inner voice that made me think about every bad thing that ever happened to me in the past. No feeling like a zombie either. I had somewhat high blood pressure before but it stayed under control most of the duration. Sadly recently it increased and my doctor is now making me switch to Zoloft. It's so sad I spent years trying all kinds of garbage that made me feel sick and never really worked. There is so little chance this new thing will have the same effect with so few side effects."

9 / 10
Was this helpful?YesNo
1 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.