L-methylfolate for Folate Deficiency User Reviews

• Anonymous
• Taken for 6 months to 1 year
• September 12, 2012

L-methylfolate "I was tested for MTHFR genetic mutations after several years of fibromyalgia/chronic fatigue-type symptoms. BINGO! I have compound heterozygous mutations. Which can cause a whole host of health issues, many I have been experiencing since youth. Once I started 7.5mg of Deplin with Methyl b12, my aches, brain fog, and unrelenting fatigue started to diminish. This is a life-changer!"

• DGa...
• Taken for 6 months to 1 year
• February 10, 2020

L-methylfolate "I have a genetic mutation called MTHFR and struggle with extreme fatigue, extreme brain fog, inflammation, etc. I am on Deplin (L-methylfolate) 15 mg dosage, and it has helped me BOUNDS. I ran out recently after being on it for 8+ months, and I could immediately tell a difference. Symptoms that had previously alleviated came back very quickly and prohibited me from being able to engage in my usual activities."

• GBi...
• Taken for less than 1 month
• September 28, 2019

L-methylfolate "I recently had a Dr’s visit with my Dr, who is treating me for ADD, anxiety, and depression. I told him about my daughter (19 years old) recently being diagnosed with MTHFR gene mutation. She has one from each parent. She has severe anxiety, panic attacks, OCD, depression, and was recently suicidal. Her psychiatrist ordered lab work and explained to us what MTHFR is and prescribed Deplin, antidepressant, vitamin B-12 500 mcg, and Vitamin D3 5,000 mg soft gels. She has completely changed! She feels much better. No more anxiety... no more panic attacks... no more depression... and she is smiling again!! My Dr prescribed Deplin for me too, but unfortunately my insurance company does not cover it (my ex-husband’s insurance covers it for our daughter), and I can’t afford it out-of-pocket. I’m still working on finding a way to get it, as I’m sure it will help me also. So blessed to have good doctors out there. I have so much respect for all their knowledge."

• Mai...
• Taken for 6 months to 1 year
• August 1, 2017

L-methylfolate "I have suffered from depression for 20+ years. I stumbled across a gene mutation called MTHFR and decided to do more research. Here is what is very important: if you have this gene mutation, then, in some form, your body does not break down folate, aka folic acid. Folic acid is imperative to serotonin levels, which affect your mood and sleeping patterns. If your body cannot produce serotonin, then taking a serotonin-based medication will never work. You are asking your body to produce more serotonin, and it can't do it; it can't produce more because it isn't able to. For people who have this gene mutation, which is a 1:2 ratio, having a supplement is important. Folic acid is broken down 8 times to reach the effective type, and my body cannot break down the first 7, so Deplin is essential for me."

• ril...
• Taken for 1 to 2 years
• February 12, 2024

L-methylfolate "If I could rate it a million I would! I have the double MTHFR gene mutation and this has been life-changing for me. I felt better within days of taking this medication. I have been on Lexapro for years, but when I started taking oral birth control pills, I was constantly crying, having panic attacks, and overall so anxious with a constant pit in my stomach. Even when I was still on the birth control pills, I noticed a huge difference from this medication, and even more now that I have stopped taking those. MTHFR shouldn't be ignored like I did for years. I pay $199 for a 90-day supply because it's that important to my quality of life (my insurance doesn't cover it). Seriously, give it a try!"

• jjo...
• Taken for 5 to 10 years
• March 9, 2014

L-methylfolate "Has changed my life, both physical autoimmune, genetic, hormonal disorders have improved and mental health PTSD, ADHD, RBD-Dyslexia have improved. I wish I had known about my mutation in childbearing years as I lost five pregnancies. My only daughter was the one I had morning sickness with and didn't take prenatal multivitamins."

• Med...
• July 11, 2016

L-methylfolate "MTHFR with some bipolar, previous ADHD, and OCD diagnoses. Started taking Deplin with B12 (methyl folate) - be sure to take both - and seeing great results. Mood improved greatly and performance overall. Couldn't imagine life without it!"

• May...
• Taken for less than 1 month
• April 15, 2018

L-methylfolate "I just started Deplin today! I've been reading people's comments, and half say it's helped them, and half have not. I've also researched it and have read so many different articles. From my understanding, you should start off at a low dose, and if that doesn't help, then take more. If the dosage is too high or low and you're not feeling better, adjust it. I personally wouldn't give up after trying it one time at one dose. This medicine has changed people's lives into feeling like a normal, happy person with energy. I personally hope it works for me, and I feel better! I'm not giving up! Try to research it before giving up. I wish everyone good luck with Deplin."

• Mer...
• Taken for 1 to 6 months
• October 17, 2018

L-methylfolate "I also have anxiety disorder. 20 mg Prozac, 0.05 Klonopin. My doctor kept telling me to take it, take it, but I've always resisted. Anyway, I'm taking it. I can't tell you how good I feel, although I didn't really know why. I didn't understand how lacking something in my body could affect the drugs I take or just my overall health. I feel great for the first time in a long time. Don't hesitate."

• pja...
• Taken for 1 to 6 months
• September 19, 2018

L-methylfolate "I started taking Klonopin after several years of depression, two bouts of major depression, and tension myositis syndrome (TMS). It helped the TMS a great deal, but after about a year, symptoms of major depression and anxiety returned. The psychiatrist wanted to prescribe more Klonopin, and when I declined that, she recommended Deplin. Deplin has helped. I now am able to wake up in the morning, and the speed of thought is almost normal. I still have mood instability, but symptoms have decreased. I also have been able to significantly reduce the use of Klonopin and hope to be off it completely as Deplin therapy continues."

• Luc...
• October 24, 2019

L-methylfolate "I am 66 years old and have suffered from ADD, depression, brain fog, fatigue, and extreme anxiety all my life. 30 years ago, I was put on dextroamphetamine 3-4 times a day, and it was a miracle. I came to life, both physically and especially mentally, and I slept wonderfully. Now that drug has little to no effect on me. My doctor, after doing a genetic test on me, says I have a gene mutation and prescribed Deplin for me. At first, I felt nothing, now, 2 months later, I feel a difference. Not a huge difference."

• Mur...
• Taken for 1 to 6 months
• January 20, 2021

L-methylfolate "I took a gene test after nearly having no luck with any SSRIs and all the negative side effects. Once I started taking this, I was able to take 5 mg Lexapro and 0.5 mg of Rexulti with no side effects, especially zero sexual side effects. I had depression, anxiety, DP/DR, and it nearly broke me last year. But this stuff, I believe, changed my life and allowed my body to react positively to the medications."

• c2g...
• Taken for 1 to 6 months
• October 14, 2024

L-methylfolate "Deplin has changed my life. If I had the choice of winning the lottery with unlimited funds or this medication, I would choose Deplin every time. I am 49, female, with ADHD. I suffer debilitating symptoms from it, the worst being poor memory and impaired executive function and focus. After taking 15 mg for just 3 weeks, I saw results. My memory went from that of an 80-year-old dementia patient to the memory I had as a young adult. I'm able to focus and actually get stuff accomplished and checked off my list every day. I was lifted right out of the sinking depression I was in due to the helplessness of living with a short-term memory problem. This pill needs to have a public service announcement made to everyone. So many people could be helped."

• Ano...
• Taken for 1 to 6 months
• April 7, 2021

"Life changing. After 3 years of trying different SSRIs that didn’t work for my depression or severe anxiety, I finally did a gene test and not only found 5 medications that were suitable for me, but they saw that I had the homozygous C667T MTHFR mutation, meaning my folic acid conversion was pretty much non-existent. This made so, so much sense for a lot of things that happened to me, and I began taking 75 mg of Pristiq (SNRI) and 15 mg of l-methylfolate supplements. After several months of these meds, therapy sessions, and even starting exercise again, I am a changed person. The hamster wheels in my head have finally slowed down, I’m not seeing darkness (figuratively) all the time anymore, and I haven’t had a panic attack in months. These results and these capsules have saved me."

• Jun...
• Taken for less than 1 month
• April 10, 2018

"Took for 2-3 weeks due to my body not processing folic acid properly. Worst side effect was I constantly felt overheated. Others were upset stomach, gas, insomnia, and increased anxiety. This drug may work for some, but for me it was not a good experience."

• Anonymous
• Taken for 1 to 6 months
• November 17, 2017

"Terrible allergic and other reactions. Doctor did not check blood levels, and I actually had no deficiencies or reason to be on this. I got very, very sick from it. Do not take unless you have ALL proof you need it, including labs showing deficiencies of l-methylfolate in your blood."

• dd2...
• Taken for less than 1 month
• December 17, 2023

"I took L-Methylfolate after watching a YouTube video. I was experiencing terrible stomach problems and losing weight that I didn't need to lose. I had had all of the gastro tests, which all indicated there were no problems. When my doctor asked me why I wasn't eating, I told her, 'I just feel so much better if I don't eat or drink (water!)'. After watching the YouTube video that described how people with 'food allergies' or 'food intolerances' could become much improved, I started to take it. The first dose was on Tuesday. By Wednesday, I felt energized and had reduced symptoms. On Thursday (which was Thanksgiving), I had the entire dinner from appetizers, soup, salad, turkey and all the sides, plus pumpkin pie (Note: I did it over 4 hours). It was an absolute miracle. Talk about being grateful. Life has remained good. No pain, lots of energy, happy, and eating. I haven't put back any weight, but I can live with that."

• RAO...
• Taken for 6 months to 1 year
• February 27, 2017

L-methylfolate "After a surprise DNA test done by my primary care doctor, I received a call from the distributor of this so-called vitamin, and the caller tried to pressure me into auto shipments of prescription before I ever received my DNA results from my doctor. My doctor had shared my DNA results with the makers of Deplin before sharing them with me. Deplin 15 caused extreme bloating and pain twice, resulting in cracked ribs, sternum, etc. I now suffer from shallow breathing and have a lump in my chest where my sternum bone broke, with damage to my rib cage and struggle to breathe deeply, though my lungs are clear. My O2 levels have dropped 5% over the past year, and I was fired by my doctor that caused this when I refused to keep taking it. Kickbacks?"

• hol...
• August 30, 2008

"Have not noticed any side effects, and it has allowed me to go off Seroquel and lose 18 pounds."