Deplin User Reviews & Ratings (Page 2)

• Ter...
• September 4, 2015

For Depression "I was born with Spina Bifida L4-5 S1-2 along with a myelomeningocele. My birth issues were due to low folate. Throughout life, I have struggled with depression, always being told it was due to the Spina Bifida. I fought through a major depression my senior year in college. When I became employed following college and had insurance, I sought counseling and medication, taking imipramine. When Prozac became available, I began it. After a decline in my health from a stroke at 33, my depression became worse, requiring hospitalization. Five years ago, I returned to my hometown and sought medical care from my high school friend. He tested me for L-methylfolate deficiency. I was deficient, he put me on Deplin 15mg with Zoloft 100mg. I am finally emotionally healthy."

• RNG...
• September 23, 2015

For Depression "Within just days of my first dose, I could feel a huge, positive difference. My mind and speech were clearer, my anxiety was nearly unrecognizable, and I was just plain happy. I admit that the cost has been somewhat limiting at times. When I have chosen to delay filling a prescription for a week or two, not only can I feel the difference, but my coworkers, family, and friends quickly point out the changes. It's an amazing supplement and worth every penny (when I have it to spare). Plan to stay on it from now on!"

• Anonymous
• June 2, 2009

For Depression "I have been depressed since 1998, after I had a fall at work and problems with the work doctors. My doctor had me try different types of medications like Prozac, Wellbutrin, Paxil, and Tofranil. Finally, the one that helped me was Effexor. At least, I thought so. Then the doctor put me on Deplin, and I felt like I hadn't felt in a very long time. That was 8 weeks ago, and now I feel great. Deplin has really changed my life. Thank you for letting me share this with you."

• Anonymous
• January 22, 2012

For Depression "In about 1 week, I noticed a drastic change. I was feeling much happier, had fewer mood swings, and even my anxiety had lessened. I like this medication because it's natural and has almost no side effects. I highly recommend it."

• CLM...
• November 20, 2011

For Depression "I found the pamphlet for Deplin while sitting in the waiting room. I was very intrigued because all of the adjunct medicines for anti-depressants usually have many side effects. My doctor was skeptical, stating that it was just a vitamin but wrote me a script. Effexor is the only one that works for me. I tried Cymbalta for pain issues and spent most of the time in tears. Before my diagnosis, I was constantly suicidal. As of late, my dark moods were back too often. But after 3 days of Deplin, I woke up feeling motivated and hopeful. I am amazed but so grateful."

• Che...
• Taken for 1 to 6 months
• March 30, 2019

For Depression "I take L-methylfolate (this medical food) once a day with my antidepressant for my anxiety and panic disorder, and I feel great. I am always very positive, and I never have anxiety. My panic triggers are gone, it is amazing. Definitely recommend to anyone having depression. It works. It's not expensive. $58 a month. Worth it for me. Also helps my folate deficiency. 100% awesome med. Never want to be without it."

• Anonymous
• April 10, 2013

For Depression "I'm so happy for you all. It's just pure hell dealing with depression, no sleep, continual thoughts, obsessive compulsive disorder, and not happy at all. Maybe if we all get figured out that this is what we need. Imagine how cheap our health insurance could go to. This is wonderful, I take folic acid and it does make a big difference."

• Myl...
• Taken for 1 to 6 months
• October 14, 2015

For Depression "I have suffered with depression as long as I can remember, high school and since. I'm 30 years old. I've tried everything to help my depression. Paxil, Lexapro, Prozac, 5-HTP, Wellbutrin, and now Celexa. Celexa did help more than the other antidepressants, but still I was suffering from depression. I lost my baby girl doggie, who was only 3 years old and was just like my child. My world fell apart, and my depression became severe, the worst I've ever experienced. I went to the doctor to talk about options as the severity of depression was overruling my life. The doctor gave me 30 Deplin 15 mg capsules samples. In 2 days, I felt alive again. I am so grateful. Look up Brand Direct Health and have your doctor send your prescription to them. Much cheaper. $65 for 30 caps."

• Aun...
• March 9, 2017

For Depression "I have taken antidepressants for years, with some improvement but mostly moderate to severe side effects, which makes me go off them. I only take Cymbalta now mostly for pain. When I began Deplin, I noticed a major improvement overnight. More energy, better disposition, and no sinking to the low lows of major depression. I have been taking it for about 3 months now and feel like a normal person for the first time ever. Best thing, no side effects."

• Anonymous
• February 9, 2012

For Depression "This medicine has been amazing. I have been on it for about 6 weeks. I am also taking Nardil, which has been effective sporadically. Finally, I'm happy all the time! I've also had to greatly reduce my Levoxyl because my thyroid is speeding up. My depression is finally gone after years of treatment-resistant atypical depression."

• Aja...
• June 29, 2016

For Depression "I started Deplin 8 months ago. I thought it was helping but I didn't notice drastic effects. I stopped taking it for 2 weeks due to the cost and quickly realized it had been working. I started feeling lethargic and unmotivated. Since I have been taking it daily, I am much more active, energetic, less moody, and I am happier. I think it is a subtle change but over time it is drastic."

• Hol...
• June 16, 2009

For Borderline Personality Disorder "Deplin has given me my life back. It has enabled me to gain control of my emotional roller coaster, my anger outbursts, and become a more down-to-earth person who is now approachable - when before I wasn't. I was lucky, my therapist recommended me to be tested for MTHFR because I also have Factor V Leiden, and MTHFR is found higher in those with Factor V (both are genetic disorders). After my results, she gave me Deplin, and the next day I woke up a new person. My husband and family are amazed, and I'm now capable of being the wife and mother that I want to be. I am so happy - and so amazed. And I feel WHOLE again."

• Anonymous
• June 18, 2011

For Depression "I have very bad treatment-resistant depression/anxiety. I was on Prozac for a year and it worked wonders until I had to keep going up in dose, and the side effects were just too bad. Since I have been put on Lexapro, Wellbutrin, Vyvanse, and Lamictal, none worked like the Prozac. Recently, my doctor put me back on Prozac, 20mg, and added 15mg Deplin. Prozac usually takes a month or longer to feel the effects, especially on a low dose. After two weeks, I felt good already with no side effects! In fact, my sex drive has actually increased. 20mg was never enough for me before, and with Deplin, it's perfect. I'm so happy."

• Anonymous
• April 28, 2011

For Depression "I've been on Deplin for about a year, and it has helped me drastically. I was originally diagnosed with bipolar and later, through blood tests, found out my bipolar was related to a condition known as MTHFR. I am compound heterozygous, meaning I have one of each genetic markers which contributes to a multitude of diseases, including mental disorders and circulatory conditions because I do not metabolize folate/folic acid. I was on Lithium for 2 years (with horrible side effects on minimal doses), and since being on 30mg of Deplin plus 5000mcg Methyl B12, I've been taken off the Lithium completely and have normal mood changes."

• Ell...
• August 25, 2014

For Depression "I was so very excited when I found out that I could be helped after being diagnosed with MTHFR. I was on Deplin 15mg a day. I actually felt fantastic after about 2 months of treatment. After about 8 months, I slowly started getting severe muscle pain and weakness, also extreme joint pain to where I could barely work or do the slightest activities. Doctors ran a ton of blood tests but found nothing. I recently stopped taking Deplin and have found that the issues have disappeared! I loved Deplin and am very sad I can't take it any longer! It also really helps with depression and mood!"

• JoR...
• September 16, 2016

For Depression "First, I want to advise others that Deplin is an adjunct to your antidepressant, not an antidepressant. I am on day 4, and already feel more clarity, better mood, and more energy. I have Narcolepsy, untreated due to being allergic to meds for this condition. So, greater energy and more awake felt great. In addition, I have been battling severe Irritable Bowel Syndrome, Gastritis, and severe upper gastric pain for 10 months. Most days I have been unable to eat other than breakfast. The evening of my first day of Deplin greatly reduced my irritable bowel issues, and since then little to no pain. I had a ham and cheese sub yesterday. It is like a miracle. Good luck to those prescribed this medication."

• cra...
• Taken for 1 to 6 months
• October 25, 2017

For Depression "Who turned the lights on?! Oh hey Deplin, it's you! This oddly classified medical food has been a welcomed step towards victory I've needed far too long, and I'm only taking the Rx for about a month. This is nothing like anything I've taken. I have Bipolar 1 & have had a slippery disaster with any and all antidepressants and have just glided along life with mood stabilizers and atypicals. I have energy, but I'm in no way jittery or hyper and I sleep like a baby. I have tons of focus & can work more effectively and efficiently, not many at a manic pace, just really focused. I found a part of myself I lost, self-esteem and confidence. When I say or act, I say it like I mean it & it's well presented. Don't hesitate to try it"

• Sta...
• August 8, 2015

For Depression "I have been taking Paxil/Paroxetine for approx. 15 years. About 2 years ago, I mentioned to my psychiatrist that I had long been very sensitive to noise. I would get really upset (angry) by the sound of the doorbell, or even my young daughter's playfulness. My Dr. recommended Deplin as an additional 'medicine'. After a couple of weeks of taking Deplin, my sensitivity improved greatly. I did not feel any different, nor have any side effects. I stopped for a couple of weeks, thinking that it didn't really do anything, and I DID notice a big difference. Although it is expensive, I will continue to take my 15mg every day (along with my Paxil). It works! My husband agrees!"

• Anonymous
• Taken for 1 to 6 months
• December 17, 2012

For Depression "I have had treatment-resistant depression for 20 years and have tried Zoloft, Prozac, Effexor, Paxil, Celexa, Wellbutrin, Lexapro, and Viibryd. Lexapro (20 mg) and Wellbutrin (300 mg XL) seem to work best but even with talk therapy, good diet, and exercise, I still have never achieved full remission. After my psych doctor retired, I switched to another who had me tested for MTHFR mutations and started me on 15mg of Deplin. Within 7 days, I felt better than I could ever remember - it was like a light switch! Test results showed I am homozygous for the C677T MTHFR mutation. I stopped taking Deplin after some agitation and anxiety started; I restarted on a lower dose before ramping up to 15 again. I have yet to see the same improvement after 3 weeks."

• Lee...
• July 28, 2017

For Depression "My doctor gave me a grocery bag full of samples because she said it was expensive. I never took them. I am bipolar with also anxiety. Depression will get very low spontaneously but is much more controlled with my Seroquel and fluoxetine and Xanax if needed. I had an appointment recently and she reminded me that I need to take the Deplin as it augments my antidepressant! I didn't realize this so I made sure to take it. Now I don't remember the last time I felt this good and functional. She gave me another grocery bag of samples. Deplin absolutely is great for me."

• Gla...
• Taken for less than 1 month
• April 5, 2017

For Depression "I was struggling with major depression and OCD and tried several antidepressants before my endocrine doctor found out I had the gene mutation. The first dose of Deplin, 15 mg, was too much for me and I felt edgy and anxious. I then tried the 7.5 dosage and honestly felt like myself for the first time in months. Clarity, energy, and focus! One side effect was headaches, and then I went online to MTHFR.net and learned I needed to supplement with a few things to feel better. This has been an answer to prayer for me. I am on 2.5 mg of Lexapro and hope to get off of it in the next 6 months. Wish someone would have told me about this sooner!!"

• Rev...
• Taken for less than 1 month
• May 23, 2017

For Depression "I have the gene deficiency, & 25% ability to make l-methylfolate myself. I have had poor results taking a variety of antidepressants over decades. Only drugs like Klonopin help my anxiety & depression. My doctor prescribed 15 mg Deplin, but I had itchy, red skin & stopped. After reading online that I might need to start at a lower dose, I obtained 7.5 mg, which I cut into 6 parts, & took about 1.25 mg per day for 4 days. Today I realized that over these days I have been feeling consistently more energetic, & do not feel as easily overwhelmed (less crying, less agitation). I'm taken by surprise that this might be working at even this low dose. I'm excited to increase the dose & add B vitamins. WOW, this could be my cure at last"

• GBi...
• Taken for less than 1 month
• September 28, 2019

For Folate Deficiency "I recently had a Dr’s visit with my Dr, who is treating me for ADD, anxiety, and depression. I told him about my daughter (19 years old) recently being diagnosed with MTHFR gene mutation. She has one from each parent. She has severe anxiety, panic attacks, OCD, depression, and was recently suicidal. Her psychiatrist ordered lab work and explained to us what MTHFR is and prescribed Deplin, antidepressant, vitamin B-12 500 mcg, and Vitamin D3 5,000 mg soft gels. She has completely changed! She feels much better. No more anxiety... no more panic attacks... no more depression... and she is smiling again!! My Dr prescribed Deplin for me too, but unfortunately my insurance company does not cover it (my ex-husband’s insurance covers it for our daughter), and I can’t afford it out-of-pocket. I’m still working on finding a way to get it, as I’m sure it will help me also. So blessed to have good doctors out there. I have so much respect for all their knowledge."

• DGa...
• Taken for 6 months to 1 year
• February 10, 2020

For Folate Deficiency "I have a genetic mutation called MTHFR and struggle with extreme fatigue, extreme brain fog, inflammation, etc. I am on Deplin (L-methylfolate) 15 mg dosage, and it has helped me BOUNDS. I ran out recently after being on it for 8+ months, and I could immediately tell a difference. Symptoms that had previously alleviated came back very quickly and prohibited me from being able to engage in my usual activities."

• Anonymous
• March 21, 2011

For Depression "I have been on Deplin for six days and I am amazed with the change in my emotions and feelings. I take 7.5mg of Deplin and 60 mg of Prozac, and I am pleased with my increased defenses to deal with my daily life. I feel like myself again for the first time in 10 years. I hope Deplin will continue to provide me with the positive attitude that I am now feeling. I feel like a whole new person."