Marplan for Depression User Reviews

• Tml...
• December 25, 2018

"I have been on Marplan for 10+ years, after trying all other MAOIs and other classes of antidepressants, and without it now for 6+ months. I can't believe that a company that has made this drug for decades cannot get FDA approval to continue. It makes no sense. I am now trying to obtain it through Clinigen Pharm (Global); and hopefully get some reimbursement from my insurance company... as it's not cheap. I say if Natulis cannot get FDA approval soon, they should consult with Roche to get the assistance they need. Why keep losing money to another country on a drug that has been manufactured here in the US for decades. Unless there is something we are not being told. I just hope it gets FDA approval again soon... especially for the unfortunate group of people that, like me, really can't function normally without it."

• Han...
• Taken for 10 years or more
• January 20, 2024

"After trying a lot of different ADs, Marplan was the one to keep me in a good place for the last 10 years. Appetite is a bit increased and maybe also energy level in general. The food restrictions do not need to be so strictly respected in my experience."

• mdu...
• June 15, 2009

"Been taking for 27 years. Only drug that had any effect on my profound clinical depression of 15 years' duration. Gave me my life back. Some side effects initially, but minor compared to the relief of depression. Wish it were more available to more people who are not helped by the more frequently used antidepressants."

• Jef...
• Taken for 10 years or more
• August 15, 2018

"I've taken Marplan for 30 years and have seen periodic shortages and transfers from one company to another. Sadly, the formula is now in the rather inept hands of Validus. I suspect they will suspend manufacturing completely now that everyone on it has had to switch to something else. Thankfully, it is manufactured in Europe by Medilink, and I get it in Denmark. Not an easy option for most people but worth looking into."

• Pet...
• Taken for 5 to 10 years
• October 1, 2017

"Marplan did an amazing job of keeping my depression away from 2010 through 2017. I'd tried Nardil and Parnate prior but had weight gain/hypomania with Nardil and ridiculously high blood pressure after each dose of Parnate. Marplan is sometimes said to be Nardil's weak little sister (as it's also derived from hydrazine, unlike Parnate, which is derived from amphetamine). It worked great for me. No weight gain, was able to perform sexually, and it kept me in a good place. Marplan always felt very clean, I never had a hypertensive issue, but it did the trick. The cost though (looking at you, Validus) is robbery. Current insurance $160/month - Jan 1st insurance won't cover, so $1500 a month. Nope."

• ede...
• March 21, 2008

"Marplan has been very effective on my bipolar depression. I have been on nearly every antidepressant available with limited or short-term success only. I have been taking Marplan for 3 months and have reduced my symptoms from continuous to occasional. My side effects were severe hypotension, muscle pain, weight gain, and inability to have orgasms. Everything has gone away except for the last two."

• Mar...
• Taken for 10 years or more
• June 27, 2018

"Did very well with Marplan after problems with Nardil and Parnate. Ten years use. Some increased appetite. Disgustingly, the drug now on manufacturing hold for at least 6 months and not available. Criminal!!"

• Ard...
• Taken for 6 months to 1 year
• November 10, 2024

"I have tried over 35 medications, two forms of TMS, ketamine IV, psilocybin, and many years of therapy. Marplan is the only treatment that has helped. I have also tried selegiline and Nardil, but the former gave me anxiety, whereas Nardil made me feel drunk, dissociated, and made me sleep nonstop. Marplan is significantly easier to tolerate (easier than many SSRIs I've taken too). I take it for depression, anxiety, and even OCD. It's effective for all of them. Diet restrictions are no issue, and I can still eat almost everything I want and can still augment with a huge number of meds, including stimulants and many other antidepressants. Yes, there can still be insomnia and sexual side effects, but they have disappeared for me pretty much completely after 3-4 months on it. It was totally worth the initial side effects. It's a pity this AD isn't more commonly prescribed. If you have treatment-resistant MDD, anxiety, or even OCD, I highly recommend Marplan."