Inclisiran for High Cholesterol, Familial Heterozygous User Reviews

• Afr...
• Taken for 1 to 6 months
• April 22, 2023

Inclisiran "Since the first injection, my A1C has spiked to 12.5, and my blood glucose is dangerously high. This has necessitated the prescription of insulin which has a range of serious side effects. While my bad cholesterol level has dropped, there has been no effect on triglycerides. Good cholesterol was in the normal range prior to Leqvio and is holding. Angina, chest pain, and difficulty moving with overall neuralgia are other unwanted symptoms. I am due for a second injection and have reservations."

• Lou...
• March 9, 2023

Inclisiran "After 45 days of use, I have developed severe muscle pain and lower body stiffness, much worse than statin pain. I do not have brain fog, muscle cramps, skin rashes, or other problems I had with statins."

• Doc...
• Taken for 6 months to 1 year
• June 27, 2023

Inclisiran "My cholesterol numbers have dropped specifically Lp(a) has gone down significantly. I like not having to give myself an injection every 2 weeks as I did with Repatha. I have some annoying side effects, however, including a productive cough, UTI's, problems, and sometimes painful urination, and frequently I feel dizzy which is very annoying. I believe that I am losing my hair due to this drug."

• you...
• Taken for 6 months to 1 year
• August 17, 2023

Inclisiran "The real answer is, I don't know. I'm on my 4th injection and haven't noticed side effects. But I have numerous problems with recovery from CABG surgery that could be misunderstood and attributed to this medication. I do have severe leg and calf cramps at times, and I am starting to believe it is Leqvio. In the past, my cramps became so severe I ended up rupturing an Achilles tendon, this was while taking Repatha. I stopped Repatha and the cramps stopped. But recently while taking Leqvio, I started similar cramps, and they can be severe. Now since the med is administered every 6 months, it is hard to stop it and see viable results, no cramps. Not sure what to do at this time."

• Jfo...
• Taken for 1 to 6 months
• September 19, 2023

Inclisiran "Don't know yet if it helped. Switched from Repatha due to cost. After the first dose, LDL was higher, but the doctor said to wait until the second dose to see. I had a bad headache, dizziness, brief shortness of breath, and exhaustion after the first dose. After the second dose, all those effects were repeated (except shortness of breath) but for a longer period, lasting over two weeks. After 6 weeks, I am still experiencing exhaustion and occasional headaches. I think I'm losing my hair and my feet itch like crazy. Is all of this related? I feel like a hypochondriac. I hope the exhaustion is not permanent. I will be going back to Repatha... I will have to find a way to pay for it."

• Mlh...
• Taken for 1 to 6 months
• April 23, 2023

Inclisiran "I had my second dose of Leqvio 2 weeks ago. I know it's working because the xanthelasma in the corner of my eye totally disappeared. I came here to give it another great review but noticed the reviews about major muscle pain. I am in extreme pain but thought it was from my fibromyalgia. I am now wondering if it's from the Leqvio? I see my doctor soon and will be asking her. So far, though, this is the only thing that has been working for me. I had that reaction to Repatha, and I hated statins."

• Sue...
• Taken for 1 to 6 months
• May 17, 2023

Inclisiran "I have had my first and second doses of Leqvio, and unfortunately, I am having a lot of muscle and joint pain - primarily in my back, neck, and shoulders. It is quite similar to the pain I was having from taking statins, so not sure why that is. It has definitely improved my cholesterol numbers, which is a plus."

• Mlh...
• Taken for 6 months to 1 year
• July 12, 2023

Inclisiran "Well, I have commented on here before about my results with Leqvio. I have had two shots now, and my side effects have been some muscle pain, and I got a condition called LPP from the Repatha which continues. This is hair loss. I don't know if the Leqvio is continuing it, but I just got my first cholesterol blood results and I am shocked! 18 months ago, my total cholesterol was 359. Today, my total cholesterol is 212, almost normal. Even my triglycerides, which it is not supposed to help, went down from 187 to 157. My cholesterol has been high all my life... over 300, so to see it this low, I am stunned!"

• Bon...
• Taken for 6 months to 1 year
• January 4, 2024

Inclisiran "It has tremendously lowered my LDL. Side effects known: bad joint pain in my hips and knees. Lethargy, lack of energy. Possible side effects, but need to discuss with my doctor: racing heart waking me up from a sound sleep."

• Nai...
• Taken for 1 to 6 months
• June 7, 2023

"I am experiencing severe muscle and joint pain, nausea, headache, sweating, palmar erythema, hives, the soles of my feet are burning hot, painful urination, and abdominal pain! Inclisiran damaged my liver! Are the side effects ever gonna go away? I was stupid to agree to have this poison. I'm really scared."

• Bil...
• Taken for 6 months to 1 year
• July 23, 2024

Inclisiran "I had Repatha shots. I had some side effects similar to an allergic reaction. Eventually, I tried Leqvio. I've had 3 shots. I had severe leg pain that lasted a couple of weeks. I could not straighten my legs. My hamstrings were killing me (I'm no wimp, I know pain, I'm a retired Marine). I also have continued pain in both of my feet (never before). One weird side effect is my right nipple is constantly hard and painful. That started with the Repatha but went away when I stopped. Now it's back. I actually saw a specialist who prescribed me a hormone treatment. I'm not taking another drug to deal with a side effect from another. The good news is it has reduced my number from 250 to 201."

• Joh...
• Taken for 1 to 6 months
• May 6, 2023

Inclisiran "I am a 74-year-old male. Just had the second dose of Leqvio. (I had to stop Praluent after two dosages due to extreme itching.) LDL has reduced by 50% after the first dosage 3 months ago. I have experienced slight muscle discomfort, but nothing major. Highly recommend treatment, but it is expensive."

• Gay...
• Taken for less than 1 month
• October 26, 2024

Inclisiran "Leqvio brought my cholesterol down by 199 points, however, the arm that was injected is seriously injured. I hope it’s temporary, but it’s hard to even use the arm at this point, and it’s my dominant arm."

• pea...
• Taken for 1 to 6 months
• November 13, 2024

Inclisiran "Equivalent to Repatha for cholesterol reduction (I've been on Repatha for over 10 years). I'm in the first 3 months phase. No side effects except one: I was on an ultra-low fat diet for 2 weeks, and in the second week I had memory loss similar to statins (could not 'reach' for words or phrases, could not remember locations of items after 3 minutes). After adding a modest amount of fat back in my diet, the memory problems cleared up rapidly."

• Its...
• Taken for 2 to 5 years
• October 14, 2023

Inclisiran "I am on 5th Jap, and this wonder drug brings down my bad cholesterol from 181 to 92, below 100, the recommended figure to be safe from a heart attack. My good cholesterol shot up to 60, but not sure it’s because of Leqvio or my food habit. I got zero side effects, nothing, but when I took Repatha, I felt like dying, so do other statins."

• Drs...
• Taken for 1 to 2 years
• July 21, 2024

Inclisiran "I took statins for 38 years. While they may have lowered my cholesterol, they did not mitigate my eventual need for CABG surgery. I took the Repatha shots for 2 1/2 years and didn't have too many negative side effects, but didn't like the need for injections every 14 days and began noticing that I would get purpura. My cholesterol level remained at good levels. Changing to Leqvio was beneficial because there is only a need for 2 injections annually, however, my cholesterol readings are somewhat higher and the purpura has increased. I fear that I am beginning to gain a little weight from Leqvio since there have been no changes in my diet or exercise routines. I am very bothered by the frequency and size of the purpura."

• Lin...
• Taken for 1 to 6 months
• August 25, 2024

Inclisiran "First off, I do have fibromyalgia and Sjögren’s, but after the first shot, the pain definitely went up, and I had chronic bronchial congestion. After the second shot two months ago, the pain accelerated in my knees, feet, legs, sides, chest, shoulders, and wrists. And I still have lots of congestion. I attributed the severe pain to the injection which, of course, as many say, did really help my cholesterol numbers greatly, but my next shot is in December, and I think I may not bother with it as the pain and anxiety that I attribute to the shot are not worth it. Reading these reviews and other reviews of this drug, it sounds like it just causes incredible mental muscle stiffness and congestion for many people. It works well for what it was designed to do: lowering all the numbers, and I appreciate that, but this is tough being in pain."

• Nic...
• Taken for 1 to 2 years
• March 30, 2024

Inclisiran "Works awesome! Knocked the LDL down to almost in range. Had to additionally take Nexletol to nail the range because I cannot take a statin... Was extremely hard to have the insurance approve both drugs."

• Wil...
• Taken for 6 months to 1 year
• December 20, 2024

Inclisiran "The drop in my total cholesterol number was dramatic the first 90 days. Dropped from about 280 to 155. My LDL dropped from something like 90 to 55. Won't have the second blood work until two months from now. Side effects: The most aggravating side effect was not diarrhea, but overly soft stools. The overly soft stools cause big-time hygiene problems. This side effect started about two weeks after the shot and continued for about a month. After the second shot, the very soft stools began around two weeks following the shot and continued off and on for a few months. Very, very aggravating. I may have had at times a slight increase in having to urinate. Barely noticeable, but it did happen, and I can't say exactly when that began or tapered off. Haven't had (so far) any undue muscle aches or stiffness."

• Jay...
• Taken for 1 to 6 months
• April 13, 2024

Inclisiran "I've just had my second injection. Cholesterol dropped, so that's a positive. I still have an injection site rash, possibly due to this last injection being very uncomfortable, unlike the first one. My IBS has been really bad this time too, but not sure if connected. Jury's still out as to whether I would have a 3rd."

• Pau...
• Taken for 1 to 6 months
• August 5, 2024

Inclisiran "I am a medical professional. I am 78 y/o. Past history of CABG X3 at age 40 in 1987, total cholesterol of 385 and high LDL and low HDL. All numbers are now substantially lowered. Chol now 165. LDL-C is 76, was 165. I haven't noticed any new problems as far as side effects after my first two injections. I have a previous history that includes sciatic distribution pain and discomfort due to mild scoliosis, cervical and lumbar spinal stenosis, and disc problems. Chronic pain controlled presently with Naprosyn and Tylenol ES. Have had no injection site problems or any other obvious new onset problems. I am 78 years old and pretty active. As with every statin I've ever taken, I always wonder whether I am having age-related loss of libido and ED vs. side effects due to medication. I cannot differentiate any new musculoskeletal pain or discomfort with current pain present long before the first Leqvio injection. I have had the first two prelim shots with the next one due in 6 months."

• cel...
• Taken for 1 to 2 years
• January 27, 2024

"I've had 3 injections, last one early December. Straight away, it floored me: headache, blurred vision, feeling weak all the time, muscle and joint pain, can't walk far, so much pain in hips, shivers, like I had influenza all the time. Quality of life-I was an energetic person. I had this injection. On a positive side, reduced cholesterol level in half. I'm due for another injection in June 24, not having it. My life has changed so much. I'll take my chances in exchange for the quality of life to return to what it was!"

• Lin...
• Taken for 1 to 6 months
• July 9, 2024

Inclisiran "Started taking first shot March 2 shot June. It is, I believe, responsible for incredible muscle. Stephen is in pain especially in my back and my ribs. It did, however, lower my numbers quite a bit, so I’m grateful for that, but I am not sure it’s worth it if I’m going to be in such severe pain. I hope that the pain goes away in a few weeks when it works through my system."

• Anonymous
• Taken for 1 to 2 years
• September 14, 2022

"After a >99% occlusion of my LAD was detected, I had a stent implanted at 43 years old. Untreated, my total cholesterol was at 360 mg/dl, with LDL 260. Atorvastatin plus Ezetimibe did not lower the numbers sufficiently. Inclisiran was prescribed by my cardiologist in 2021, and 2 weeks after the first injection, my numbers are amazing. LDL has been below 55 mg/dl ever since. No side effects except for the rather painful injection. Amazing. Will undergo coronary radiography in 2024 to assess whether the good numbers translate into disease regression. (I'm from Germany, where Inclisiran was approved in 2020.)"

• Sou...
• Taken for less than 1 month
• June 4, 2024

Inclisiran "This is in regards to side effects of Leqvio. Had the first injection about five days ago. No pain or redness at the injection site. A bit of soreness at the injection site for about 24 hours. A lethargic feeling off and on since the injection. A small amount of muscle or joint pain in the first 72 hours after the injection. No diarrhea as yet. Slightly loose BMs. No fever. Have experienced periods of being 'light-headed', i.e. feeling faint. Have not communicated this to my physician yet. Will do so later this week. I am hopeful this injectable medication will lower my LDL and thus, my total cholesterol number."