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Guaifenesin / pseudoephedrine User Reviews & Ratings (Page 3)

Brand names: Mucinex D, Mucinex D Maximum Strength, Guaifed, Decongest II, Desal II, Mucus D, Degen II, Tusnel Pediatric Drops, Entex PSE, Nalex CR, Mardrops-EX, Congestac, Poly-Vent IR, Despec-Tab, Entex T, Guaimax-D, Anatuss LA, Fenex-PSE, G-Phed, Guaibid D, Nalex Jr, G-Phed- PD, Guaivent PD, Guaibid D Pediatric, Eudal SR, Duratuss GP (old formulation), Deconsal LA, D-Feda II, Guaifenex PSE 60, Demibid II, Guiadrine II, Guiatex II, Ambifed, Guiadrine II SR, Defen-LA, Deco-D, GP 500, Guaifed-PSE, Guiadrine PSE 120, Guai-Vent/PSE, Guaifenex PSE 120, Guiatex PSE, Guai Sudo, Guaipax PSE, Ami-Tex PSE, Ru-Tuss DE, Guaifenex RX Guaitab Guiatuss PE Guaivent (Ethex) Altarussin PE Sinutab Non Drying Robitussin Severe Congestion Humibid GC Guaifenex GP Dynex ExeFen-IR Durasal II Guiadrine PSE Guiatex II SR Coldmist Drituss GP Coldmist LA Coldmist Jr Ambifed-G Guaifenex PSE 80 Aldex GS Despec-SR Guaifenex PSE 85 Maxifed ExeFen Mucus Relief D Ambi 60/1000 Ambi 60/580 Ambi 80/780 Aquatab D Dose Pack …show all brand names

Guaifenesin / pseudoephedrine has an average rating of 6.1 out of 10 from a total of 253 reviews on Drugs.com. 48% of reviewers reported a positive experience, while 29% reported a negative experience.

Reviews for Guaifenesin / pseudoephedrine

  • Ano...
  • July 14, 2017

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "Make sure to take it early in the morning when you have just woken up because you will be awake for hours. Do not take it before sleep like I did, unless you want to stay awake until 6 a.m. the following day. Other than that, it works."

5 / 10
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  • Sle...
  • Taken for less than 1 month
  • November 5, 2016

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "First time ever taking Mucinex D! Took two pills as directed, and it did clear some sinus pressure during the day. Following directions 12 hours later and took my two pills dose at 10 PM. I've been clear in my sinus, but tossing and turning all night! It is now 2:05 AM! Insomnia was a side effect, so did not read about it until now, since I can't sleep! So, yes, Mucinex D does work, just do not take it at night as directed. Unless you need to be awake while others sleep, in which case, this will definitely keep you up, all alert!"

1 / 10
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  • Anonymous
  • September 27, 2020

Mucinex D Maximum Strength (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I had the worst experience with this Mucinex D Maximum Strength. I could not stop coughing and felt my blood boiling inside my body. This gave me anxiety and insomnia. Do not try it unless you want to feel like you're dying."

1 / 10
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  • mad...
  • Taken for less than 1 month
  • February 8, 2020

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "Thankful I found this site to calm my nerves. I took Mucinex D around 11 PM and fell asleep for about an hour, woke up to my whole body shaking. Of course, started to think of the worst, so made the shakes worse. Then realized it was a part of the side effects of Mucinex D. I will no longer be taking."

1 / 10
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  • Kel...
  • Taken for less than 1 month
  • October 15, 2018

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "This drug works wonders. Clears me right up and loosens my mucus so that I’m feeling myself by the end of the week and back to normal instead of feeling the absolute same (if not worse) and trying to book a last minute appointment with my physician. For any of you who expect to feel normal in just a few short hours and want to sleep like a baby after taking it at 9 PM, you’re being unrealistic. Read up on the drugs you take before putting them into your body - the pseudoephedrine will keep you awake, so take it in the morning."

10 / 10
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  • Bab...
  • June 24, 2016

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "Awful as I'm writing this. It's 1:30 a.m., and I am up, and I can't sleep, and it made me cough so much more! I have a baby, and now that I can't sleep because of this medicine, I'm going to be miserable tomorrow! I don't recommend it to anyone!"

1 / 10
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  • Liz...
  • Taken for less than 1 month
  • October 29, 2015

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "It's worth buying the day and night Max Strength to get you going again. It does make you have dreams and talk in your sleep, but I'd rather have that than coughing with a runny nose. It seems to dry up the mucus real quick. So, I recommend the day and night if you want the full 24-hour effect, and I only take one set of pills for the day and one set of pills for the night. Thanks, Mucinex!"

10 / 10
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  • AGa...
  • September 19, 2018

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I took this medicine at 8 PM, hoping I would go to sleep normally and just feel better in the morning. Here I am at 1:36 AM, wide awake with 0 sleep and 0 sleepiness, which is super frustrating since I have a whole day of work starting at 8:30 AM. I didn't know the pseudoephedrine ingredient was so potent at keeping you awake, if I had known, I would have definitely not taken this. My heart is racing, and I just feel really anxious. I’m hoping this feeling will go away soon, as I’m getting worried."

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  • Hin...
  • Taken for less than 1 month
  • November 20, 2019

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "Do not take this at all unless you want to be up and feeling like you are never ever going to sleep again. I was taking DayQuils until my very smart girlfriend offered me a mucinex in the middle of the night. Never ever take this or any other med containing pseudoephdrine whatever you are going through is not worth the anxiety and insomnia. I also threw up as well which tasted exactly like the Mucinex"

2 / 10
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  • No...
  • June 1, 2015

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "Best stuff ever! I could not breathe or stop coughing. I had to go to the hospital after going to the doctors and getting no relief. The hospital gave me Mucinex, it started to work immediately. Got the over-the-counter and getting better! Thank you!"

10 / 10
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  • alc...
  • January 19, 2017

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I take Mucinex D 600/60 mg every morning for chronic sinus issues. It has helped considerably with sinus headaches. I would not recommend taking the 1200 mg strength, nor should you take 2 of the 600 unless it is early in the morning... and only for a couple of days. The 1200 mg strength has 120 mg of long-acting Sudafed... that is too much from my experience. Do not take this med after say 12 noon. It will keep you awake for at least 8 hrs! Also, if you take this long term... it is not something you want to quit suddenly... wean yourself off to prevent irritability, etc."

8 / 10
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  • Anonymous
  • Taken for less than 1 month
  • February 15, 2017

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "Would not recommend. A 20-year-old college student who desperately needs sleep but hasn't because the label on the box forgot to highlight and bold 'You won't be able to sleep!!' Took two pills at 10:30 a.m., and about an hour later, I was very jittery, paranoid, anxious, and my heart rate was going insane. It's now 10 p.m., and my eyes are still dilated, and I still feel weird. Would not recommend the whole dosage, or just stay clear in general."

2 / 10
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  • mol...
  • August 1, 2017

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "For those experiencing nervousness and jitters, just keep in mind pseudoephedrine is a stimulant drug similar to amphetamine and methamphetamine. All cold drug names with a 'D' after them have pseudoephedrine, so get the same drug without the 'D' in its name."

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  • Cha...
  • March 5, 2015

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "The medicine itself works to relieve chest/nasal congestion, but it keeps me from sleeping. First night, I was thinking maybe it was because I was traveling, but the second night, same thing, and it's almost like it automatically wakes you at around 2 AM. My second dose yesterday had me jittery and groggy during the day. Don't know if I will continue to take this or not. I need sleep!"

8 / 10
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  • Anonymous
  • Taken for less than 1 month
  • September 23, 2012

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I developed a serious cold with immense pressure from my sinuses on my eyes and head. The first day at 7 a.m., I took two Mucinex-D (clears nasal/sinus congestion, thins and loosens mucus) in the morning, and sure enough, within hours my nasal passages cleared, and there was a constant flow of mucus throughout the day. I was sneezing all through the day. Again, I took two at 7 p.m. in the evening, same result. I slept for maybe 3 hours and then was up all night until 6 a.m. All night, I was constantly blowing my nose and sneezing. The next morning, I took two. Maybe tonight I will not take any. The only discomfort I notice is my left nostril that is the one most clogged, it is constantly itchy, like I want to sneeze all the time, and of course, the insomnia."

9 / 10
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  • Ama...
  • December 1, 2012

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "Love this. When I get a sinus infection, it's very stubborn, and having been given antibiotics way too often all my life, they don't really work anymore. I try to tough it out usually, but when it gets so bad that I'm reaching for my Afrin multiple times a day (a blessing and a curse as it works almost instantly, but causes rebound congestion), I head out and grab some Mucinex D. My doctor warned me about the insomnia the first time she recommended it, so I knew what to expect, but honestly, it's worth it to me to be able to breathe. My ears usually feel even more clogged up at first when taking this stuff, but that clears up after the first 24 hours, and I'll take that over the facial pain from sinus pressure."

10 / 10
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  • Bro...
  • Taken for less than 1 month
  • December 28, 2016

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "After having a sinus infection for three days, I went to the immediate care center, they recommended Mucinex D and a saline nasal wash. I felt relief from the two combined methods that I started that morning. However, after taking the second dose of Mucinex D that night, I found that I only had a couple of hours of interrupted sleep. Now, on my second night, while the congestion is much better, I am still not sleepy - even after hardly sleeping the night before. I checked the Internet and found this site, apparently, this is not uncommon. Tomorrow, I will only use it during the day and rely on the saline nasal wash more."

7 / 10
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  • She...
  • Taken for less than 1 month
  • October 10, 2016

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "It's 3 a.m., and I'm wide awake. Took Mucinex at 1 p.m. this afternoon, which helped relieve some of the pressure in my head caused by congestion. Took NyQuil at 9:30 p.m., hoping it would knock me out like it usually does, but no such luck. I only took 1 pill at 1 p.m. yesterday, but I guess since it's a 12-hour medicine and I'm a small female (103 lbs, 5'4"), it's still affecting me a lot. My husband swears Mucinex made him feel better, but I say no thank you. I'd rather blow my nose all day and be able to sleep at night. Will not be taking again."

4 / 10
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  • Liz...
  • September 9, 2016

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I tend to get a sinus infection at least twice a year. The only thing that helps me during this time is Mucinex D. However, after the first time taking it and not being able to sleep, I decided to take one pill every 6 hours instead of 2 pills every 12. Taking it this way allows me to breathe and still be able to sleep at night. For me, it is a miracle worker."

8 / 10
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  • Nnn...
  • November 12, 2015

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "It helped with the runny nose and cough, but I think the side effects made it not worth taking. The first hour was the immediate release, and it made me feel nervous, anxious, dizzy, nauseous, and I had awful tremors. After the first hour, I came down a bit and didn't feel as awful. Couldn't get any sleep on it, and being a mom of a one-year-old boy, I definitely need my sleep. I won't be taking it again. Going to go back to DayQuil, NyQuil, cough drops... Not for everyone."

2 / 10
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  • Lyn...
  • Taken for less than 1 month
  • January 8, 2019

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I struggled with cough and congestion for two weeks which turned into a sinus infection. I finally bit the bullet and bought Mucinex D. Within an hour of taking it, my symptoms were manageable. The sinus pressure and pressure in my ears was still there, but decreased, and my headache was almost gone. Every person will react differently to Pseudoephedrine. I’m fortunate enough to not be affected by the unpleasant side effects. I slept like a baby for the first time in weeks (10 hours after taking it at 5pm.) If you do not know how it will affect you, take it in the morning. The price was not much different than the Mucinex you can grab off the shelf. $13.00 for 18 tabs. Well worth it in my opinion. I swear by this stuff and will definitely use it in the future even though it’s a bit of a hassle to get your hands on. The pharmacy keeps it locked behind the counter and you must ask for it and present your ID."

10 / 10
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  • Why...
  • April 17, 2013

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "Yeah. If you want a good decongestant, Mucinex D is for you. Took my first dose at 4 PM, warned that it could cause 'sleeplessness.' Thought I was in the clear, but low and behold, I am here writing this review to the world after that one dose. Current time: 7:15 AM. Taking another just to keep me up for class today. Hurray."

7 / 10
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  • Not...
  • Taken for less than 1 month
  • October 25, 2019

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I have learned to only take this in the daytime due to the stimulant effect of the pseudoephedrine ingredient. I switch to plain Mucinex at night plus Afrin for the 3 toughest days of my miserably long colds."

8 / 10
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  • Joe...
  • March 1, 2009

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "I had sinus congestion and consequently serious pain under my eyes in the sinus area accompanied by confusion and inability to think clearly. After one Mucinex D tablet, the pain was gone. I suffered from mild insomnia that night, but I'd rather have the insomnia than the pain. I also had less ear pressure/pain during descent in an airplane after taking this drug. Another benefit for me. Thanks, Mucinex."

9 / 10
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  • The...
  • Taken for less than 1 month
  • December 15, 2015

Mucinex D (guaifenesin / pseudoephedrine) for Cough and Nasal Congestion "My mom caught the cold I have just beaten, and it affected her much worse. After consulting a doctor/friend, she recommended trying Mucinex 12 hour. At around 7 PM, she took two 600 mg tablets. She reported being awake all night with heart palpitations, jitters, and a pounding headache. She also threw up in the middle of the night and feels nauseous again this morning. The cough is coming back as the Mucinex wears off. The drug worked to stop the coughing, but the side effects can be hard on some."

1 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.