Collagenase clostridium histolyticum for Peyronie Disease User Reviews

• PW...
• Taken for 1 to 6 months
• November 13, 2022

Xiaflex (collagenase clostridium histolyticum) "Worst medical decision I’ve ever made! Xiaflex permanently damaged my penis. I haven’t had sex in years now. At least with Peyronie’s, I was able to function sexually, but after Xiaflex, my penis is useless! It literally damaged it to the point where it’s no larger erect than it is flaccid, and flaccid, it’s smaller than the surrounding skin, so I’m constantly having to reach into my pants to pull it back out of the surrounding skin. It’s uncomfortable, embarrassing, and humiliating. Things like riding a bike or hiking, or even working around the house are a constant battle with keeping the thing from being 'inside out.' I consider the outcome to have been penile mutilation. I had a nice average-sized penis before Xiaflex, but now, it’s literally a micro-penis! Do you realize how difficult it is just to put that into writing? I can't stand what’s happened to me, but if this can save someone else the disfigurement and permanent damage, then it’s worth it."

• Dep...
• Taken for 1 to 2 years
• September 8, 2020

Xiaflex (collagenase clostridium histolyticum) "Xiaflex is horrible. Before the treatment, I had about a 30-degree bend. After 4 incredibly painful injections and a hematoma, I now have a 45-degree bend, but the worst of all is the incredible shrinkage in both length and girth. This has absolutely destroyed my self-confidence. I now have about 5 times as much scar tissue as I started with. Don't do these injections. They absolutely will make your condition worse."

• Nin...
• Taken for 6 months to 1 year
• February 26, 2020

Xiaflex (collagenase clostridium histolyticum) "After suffering from Peyronie's disease with 90 percent curvature, I finally agreed with my urologist to have the Xiaflex treatment. It was a disaster. I am worse off than before the injections, incredible shrinkage and still curvature. I wish I had never gone through with it. Ruined my intimacy with my wife and psychologically messing me up. I highly recommend not having the treatment because it just doesn't work. I have had 8 injections."

• Chu...
• Taken for 6 months to 1 year
• January 25, 2021

Xiaflex (collagenase clostridium histolyticum) "I went through a course of Xiaflex for Peyronie's. Honestly, I think the drug is a waste of time. I spent over $7,000.00 with insurance. The doctor said it was going to work and be fine, but it did not correct it at all. Mine is manageable for sex, but my advice is if yours is bad, surgery might be your only option. Imagine spending $7,000.00 without any results - only drug companies can get away with these types of scams. It's like buying a car and they don't give you the engine. I chose not to do surgery because I can still function, but as I said, don't waste your money. I am hoping one day some law firm will do a class action suit for fraudulent claims made by the manufacturers of this product."

• Sex...
• Taken for 1 to 2 years
• August 6, 2019

Xiaflex (collagenase clostridium histolyticum) "I was diagnosed with Peyronie's in 2018. My primary physician sent me to a urologist who recommended Xiaflex injections. He said that the success rate was high. Well, that was a false statement. Xiaflex ruined my sex life, and now instead of having curvature on the left side of my penis, it's now moved on top, which the curvature is worse than ever. This has been an emotional struggle for me, and I don't know what to do. I'm sure a lot of men with this condition are struggling as well with emotions. My advice to all men with Peyronie's disease: DON'T GET INJECTIONS! IT DOESN'T WORK!"

• Dev...
• May 2, 2021

Xiaflex (collagenase clostridium histolyticum) "This is an absolutely horrible drug and treatment that did nothing to improve the curvature of my penis and actually made things worse. I went through all 8 injections over a 6-month period and followed the instructions to a T, but in the end, not only did it do nothing to lessen my curve, which is about 50 to 60%, but it made my penis shorter by about an inch. Peyronie's shortens your penis anyway by about an inch to an inch and a half, so this just devastated me. In the end, my penis is more than 2 inches shorter with the same curve. Additionally, I have had pubic area pain that is intermittent, which I attribute to the injections. For 6 to 8 months, I had a bruised and swollen penis that I had to stretch as part of the treatment, which was excruciating, and for 6 months after the last injection, all I did was cry because it failed. I know that sounds pathetic to some, but this is a very lonely disease to deal with, and this company that created Xiaflex needs to be held accountable for this."

• Unh...
• June 15, 2023

Xiaflex (collagenase clostridium histolyticum) "Do not undergo this treatment! I wish I had never heard of Xiaflex. My Peyronie's disease wasn’t great, but I’d give almost anything to go back to the way I was before Xiaflex. It destroyed my penis. Even my urologist was surprised when he witnessed how much length and girth I’d lost. Of course, neither he, the hospital, nor the manufacturer helped in any way. Plus, it’s super painful! Not worth it!"

• Pen...
• September 10, 2019

Xiaflex (collagenase clostridium histolyticum) "Warning to men considering this treatment for Peyronie's. I had a curvature to the left which I wish for the love of God I had back. After months of treatments with Xiaflex, I now have it right in the top middle and worse than ever. Penis shrinkage and all. Hurts like hell to have sex, not to mention the emotional part. It is embarrassing. I do not know what to do."

• Fre...
• Taken for 6 months to 1 year
• November 10, 2022

Xiaflex (collagenase clostridium histolyticum) "I was on my LAST injection, and it sent me to the ER! The other 7 injections did NOTHING! I’m in so much pain and misery right now! I can barely walk! Swelling and discoloration are the worst right now, and every time I walk, it feels like my penis is in a blender or being twisted by a psychopath! How is this product so expensive and 'safe'?"

• Bob...
• May 13, 2019

Xiaflex (collagenase clostridium histolyticum) "I couldn't complete the full treatment of 4 double injection cycles. During the 3rd cycle, after both injection #5 and #6, I developed excruciating pain, radiating from my hips to my knees. Both times, the pain was so intense, I lost control of my legs and fell to the floor. The pain lasted 15 minutes. The doctor told me no other patient had experienced that reaction. During a subsequent visit, I was told that a second patient had. The treatment did decrease the Peyronie's bend from 40º to 30º. Another serious, negative side effect was that flaccid and erect penis length and girth shrank dramatically after treatment. The doctor attributed it to the Peyronie's disease, but I took pictures just before Xiaflex treatment, (10 months after the onset of Peyronie's) and after treatment, and the size difference is dramatic."

• Mar...
• Taken for 6 months to 1 year
• October 22, 2019

Xiaflex (collagenase clostridium histolyticum) "Have Peyronie's with a 90 degree bend. Did 3 cycles of Xiaflex, a total of 6 injections. Got a hematoma after the sixth injection. End of Xiaflex treatment. Still have a 92 degree bend up and now a 30 degree bend to the right. Total waste of time and money. Not to mention the pain of the injections and the hematoma. Insurance paid $30,000 for this treatment and total failure."

• 1st...
• Taken for 1 to 6 months
• June 4, 2021

Xiaflex (collagenase clostridium histolyticum) "I have completed my 3rd series of Xiaflex, 6 shots... WASTE OF TIME!! Not to mention the pain and swelling. I now have more of a curve in my penis than when I started. Scheduled for a fourth series, but I will not be going. There has to be a better way. I just hope I haven't gone so far that I cannot fix it."

• Los...
• Taken for 1 to 6 months
• September 23, 2021

Xiaflex (collagenase clostridium histolyticum) "Had mild curvature of 30 to 35°, loss of 0.5 inches. First round of Xiaflex, mild hematoma, doc said it's normal. Extreme pain and daily discomfort followed since April 2021. After the first round, another loss of length and girth and worsening of curvature. Have not measured it 'cause I can't bear to even look at my penis anymore. Broke up with my gf 'cause sex is too painful, and it's disheartening not being able to please her. Even after two years of this disease, masturbation is still painful, and I doubt it is stable now. In my opinion, this drug is a last resort only. Consider other options, i.e., surgery. Really take your time about it, do not listen to others about having trust in your doc, do your own research about all the side effects. I am 38 years old, single, and this is what I will be for the rest of my life now. This disease affects us in so many other ways people can't even fathom."

• Mon...
• Taken for 6 months to 1 year
• June 19, 2019

Xiaflex (collagenase clostridium histolyticum) "Three series of 2 injections (2 injections - 1 injection, then the other in 2 days, 3 months between series, had 6 shots in 9 months). Horribly expensive and very uncomfortable during and after injections. No improvement - worthless - a medical businessman's scam. At least an auto mechanic guarantees his work."

• Joh...
• Taken for less than 1 month
• May 26, 2022

Xiaflex (collagenase clostridium histolyticum) "This medicine destroyed my penis. It will literally eat away at your penis, and you will never reclaim what this drug will take from you. Don't let this drug go anywhere near your dick. I sure wish I hadn't."

• Joe...
• Taken for 1 to 6 months
• March 2, 2021

Xiaflex (collagenase clostridium histolyticum) "4 injections into my plaque by a very experienced urologist made my mild deformity much worse. I went from a mild indentation and curve to an extreme curve with a hinge effect. This treatment is overpriced and can make your condition worse. It should be taken off the market. Total rip-off."

• Jim...
• Taken for 6 months to 1 year
• February 5, 2022

Xiaflex (collagenase clostridium histolyticum) "Guys, do not get your hopes up. This is a very expensive and extremely painful waste of time. I am left a shell of a man. My PD is as bad as ever. Ninety-degree curve and a year later painful. Xiaflex is pure garbage."

• Spu...
• Taken for 1 to 6 months
• February 28, 2021

Xiaflex (collagenase clostridium histolyticum) "Xiaflex worked to a degree as my urethra was partially blocked. But my unit went from a thick 6 inches to an anemic 3 inches at most. 2 years after my final treatment, it's embarrassingly small and stretching does nothing. I'm less of a man than I used to be, and I remain single now by choice. I would try any other treatment and use Xiaflex only as a last resort."

• Han...
• Taken for less than 1 month
• March 8, 2023

Xiaflex (collagenase clostridium histolyticum) "I had Xiaflex injections at a urologist that specializes in Peyronie's treatment. The first couple of shots did get rid of some scar tissue, but after the third shot, I developed some abdominal pain that only occurred after exercising. It felt like I had a hernia. I went to a doctor for treatment, and they could not find anything with X-rays or a CAT scan. This pain went on for seven months. I canceled the rest of my treatments and just use the traction device. I would only recommend this if you catch it early and you have a slight bend. Even the urologist that gave me the treatment is on camera saying the injections have limited effect. Do your research before you take the treatments."

• Sad...
• Taken for 6 months to 1 year
• March 24, 2020

Xiaflex (collagenase clostridium histolyticum) "I went through 6 series of shots. A series consisted of getting a shot, waiting 2 days, getting another shot. Then you wait 5 weeks and start the next series. Each time after getting the first shot, my penis, scrotum, and entire groin area would bruise badly. A real struggle to go in 2 days later for that next shot... Literally, one of the hardest things I've had to do in my life was lie there while a needle was stuck in my penis. But getting rid of that curve? Totally worth it - if it had worked, but it didn't. Unlike some of the other reviewers, I guess I should be grateful it's not worse."

• Wre...
• Taken for less than 1 month
• May 5, 2022

Xiaflex (collagenase clostridium histolyticum) "Had about a 35-to-45-degree curvature in the middle of the penis. Sex was possible, but sometimes painful. I should have left well enough alone. Only had one shot. Did everything they tell you to do. It straightened it out because my penis shrunk so much that the middle of it is basically gone, plus the girth is about two-thirds of what it was before. No mention of that by the doctor or in the literature. Don't know how this stuff is legal. Worst decision of my life."

• Dis...
• Taken for 6 months to 1 year
• April 30, 2022

Xiaflex (collagenase clostridium histolyticum) "I wish I had read more about Xiaflex before agreeing to be treated. I went through all 4 cycles, 8 injections in total. After 2 cycles, I saw no improvement. Now, I wish I had never done it at all. After the 4 cycles, my problem is much worse. The fibrosis grew. The bend that used to be a slight slope now bends like a knuckle. I'm far worse off than before I was treated with Xiaflex. I'm now doing daily penile traction therapy, hoping to see some improvement over time. I would say to anyone considering Xiaflex for Peyronie's, don't! You will most likely regret it."

• Dav...
• Taken for 1 to 6 months
• November 5, 2019

Xiaflex (collagenase clostridium histolyticum) "The bend moved to the top middle from being closer to the tip. The bend is somewhat lesser, but now the length and girth are a lot less also. Take your chances on that it will go away by itself. Not worth the cost, pain, and decrease in size. Now what can I do? Should be lawyers begging for my business with lawsuit. So annoyed!!!"

• Sha...
• Taken for 1 to 6 months
• July 22, 2022

Xiaflex (collagenase clostridium histolyticum) "Completed 3 cycles. So far, no improvement. 65 percent curve. I also use a stretching device that I paid $540 USD for from the Mayo Clinic. Lucky for me, I have good blood flow and get hard erections. It still works, and the people I have had sex with do not seem to mind me having a curve. The only other option is to continue stretching or stitch it straight. An implant would only happen if I had ED. Maybe someday they will develop a better grafting material that stretches like a natural penis. It sucks turning 60."

• Ano...
• April 2, 2021

Xiaflex (collagenase clostridium histolyticum) "It's been 9 months and 2 injections every 6th week. No discomfort after initial injection. Always bruised for a few days. Went from 75% curvature to 50%. Opted to continue. Must go to an expert in this field. The details are important. The stretcher must be from Mayo Clinic. Must adhere to wearing it as directed. The stretcher allows growth of good tissue in the right area. My doctor has treated over 5,000 patients from all over the world. UCSF has their own PD unit. Highly recommend."