Aplenzin for Depression User Reviews

• Ano...
• Taken for less than 1 month
• September 29, 2024

"I am purely posting this review to educate others in my position so that they don’t experience the same problem. There are many others like me online in other postings that have developed tinnitus from this medicine. Please know that this is a risk with this drug as it’s not very commonly known, moreover, the FDA doesn’t take tinnitus into consideration when looking at the safety profile for approval. From what I’ve read, tinnitus is more common at the 348 mg dose and higher and as a combo medicine with other psychoactive drugs. I was pushed to start this drug in combination with Effexor at 150 mg. I started for a week on the 174 mg and then was given the 348 mg. By the end of the 2nd week, the tinnitus set in and has been a problem since I discontinued 2 years ago. Again, I’m sure this medicine has worked for others, but I feel compelled from an ethical perspective to educate others of this possibility as to prevent others from having the same problem that I and others have been dealing with."

• Chu...
• June 24, 2018

"I survived for 20 years on many medications. Wellbutrin was hideous. On it, I couldn't sit up, walk, think...like I was dying of terminal flu. Effexor helped, but not much. Soon I gave up; my wife suggested magnet therapy. (Insurance said we had to prove that medicine didn't work for 2 years.) Time's up, but I finally got an Aplenzin sample. I knew of no similarity between Aplenzin and Wellbutrin. Hours after taking a pill (522), my face lightened as if a dark veil had been lifted, my spirits soared, I had focus and motivation to accomplish tasks, and I wasn't raging as much. I haven't felt this way for 20 years...no, forever! No comparison...I have no idea about its efficacy long-term, but I rated Aplenzin 9, because of side effects (which I gladly embrace). Our chemistries are all different; different drugs affect everyone in a personal way. All I can say is...I finally found the medicine I've needed for 66 years!"

• BBa...
• Taken for 1 to 6 months
• May 3, 2019

"I have been on Wellbutrin for years. My doctor tried me on Aplenzin 522 mg. I felt better, and there was hope, then my insurance quit paying for it. What sense does it make to make a drug that no one can afford and give out samples and make people get false hope that things will get better? I feel this is just cruel!! But it is a good drug if somehow I can afford it!! It was possible that I could concentrate, didn't gain weight! Felt almost normal!! Thanks for letting me down."

• MDD...
• September 11, 2013

"I'd been on Wellbutrin/Wellbutrin SR for over 15 years, and it worked great until about a year ago when I started feeling I'd built up a tolerance to it. Seeing that Aplenzin was basically the same, but in hydrobromide form instead of hydrochloride, I figured it would 'trick' my body into reacting to it as a new medicine without losing the benefits. With the blessing of my psych doc, I switched, and it appears to have worked. I'd give 10 stars, except for the high cost."

• Tha...
• May 2, 2009

"I have bipolar disorder, panic attacks, anxiety, major depression - needless to say, there's a lot on my plate. However, for my depression, Aplenzin has been working very well. I don't get so frustrated over the extremely simple things, like not finding a sock (as a personal example). Overall, I think Aplenzin is good. Aplenzin gives me energy and helps my personal outlook. I take 522 mg a day. I'm pleased with this medication, I do, though, take into consideration that I've only been on it for about a week, so I am on alert for any changes. Aplenzin works great for my depression so far."

• Cha...
• December 22, 2020

"I am a 39 yr. female with depression, ADD, and hypothyroidism. I take Adderall and natural thyroid for my hypothyroidism and ADD. I have tried many drugs before for my depression including Zoloft, Celexa, Lexapro, Effexor, Viibryd, Trintellix, and Wellbutrin. I did well on a combo of Wellbutrin and Zoloft for many years, but the generic forms of those meds are inconsistent and toxic. I had zero side effects on 348 mg for 2 months. When I increased to 522, I began having sore muscles and eye dryness. Aplenzin gives me mental clarity, balance, motivation, and it helps control emotional eating. Before taking Aplenzin, the process of thinking, planning, etc. drained me. I now have much more mental energy and physical energy as well. The day passes by slower, which is great for me because I get more done with less effort. Everything feels so much easier, like work, cleaning, and running errands. Also, better libido!"

• UNE...
• September 23, 2009

"I was on Wellbutrin HCL SR 200 mg for 10 mos, and I noticed a significant improvement with my depression. However, I started to crave cocaine because my dopamine levels are low. My doctor switched me to Aplenzin 348 mg ER. I have been on it for 2 weeks now, and I have noticed a great improvement with my concentration, ability to get projects completed, and not focusing on cocaine cravings. It has helped with my emotional eating too. I actually feel like I am a normal 40 yr old married mother of 2 boys. I feel like cleaning my house instead of sitting on the couch in front of the T.V. all day. The only minimal side effect I have is increased sweating. I am hoping that this will subside after a few months of taking this medication."

• Not...
• February 1, 2010

"Celexa and Zoloft made me feel detached from life, so I wanted to try Aplenzin. At first, I thought it was the wonder drug. I felt alive, full of hope and energy. I cared about my future and could get things done. I was so happy, possibly euphoric. I stood up for myself and felt in control. I thought I had found the answer. That was on the low, intro dose (174?). Then I went up to the middle recommended dose (348?). All that good stuff disappeared. Can't sleep, feel like I'm on the verge of panic attacks. Found myself watching the colors on TV, and the colors owned me. Never had this experience before. Mood swings and deeper depression now. Want that good feeling back. Have a call in to the doctor about going back to a lower dose."

• Leo...
• Taken for less than 1 month
• January 26, 2019

"My psychiatrist gave me some samples to try. Days one and two were not bad. I started feeling kind of dizzy and almost like I was in a bubble on day three. Day four was horrible. I was very dizzy, my joints started aching so badly I could hardly walk down stairs. I was so unbelievably cranky and mean, it was horrible! By 6 PM that night, my face was bright red, and I felt like I was drunk! I didn’t take one this morning, and I’ve been having stomach cramps and diarrhea since this afternoon, hopefully it doesn’t take too long for this to get out of my system!"

• San...
• March 30, 2010

"Aplenzin unfortunately did not work for me. I have panic disorder, which then sent me into a horrible state of depression. My psychiatrist first prescribed me Wellbutrin SR, which I was taking twice a day. After about 3 months, I started having moments where I was actually happy to be alive. At my next appointment, my psychiatrist asked if I would be interested in trying Aplenzin because it only needs to be taken once a day. I started off on 348 mg for three months. This was not working, so he switched me to 522 mg. Two months later, it is still not working. I spoke to my pharmacist, who told me that I have been patient enough, and if it is going to work, it would have done so by now."

• Anonymous
• October 28, 2009

"I switched from Wellbutrin to Aplenzin 3 months ago. I had a good sex life before on Wellbutrin. I switched my medication instead of increasing the dose of Wellbutrin. Now that I am on Aplenzin, I feel numb. I had this same feeling when on Zoloft."

• Tur...
• October 10, 2020

"I've been taking Wellbutrin (name brand only because the generic doesn't do anything, plus good insurance) in one variation or another, SR's then XL's without one single side effect in all the years I've been on it. Since the Seasonal Affective Disorder gets pretty bad in the winter, I'm taking the max dose of 522 mg. I started taking it on October 3rd, and at first, I felt like actually being productive, going for walks with my iguana, etc. I've experienced a few side effects, such as a slight headache (has since gone), sore muscles (very minimal now), vision issues (just came on recently), and they're tolerable. Well, recently, the energy has ebbed somewhat, and I'm back to not being as productive. It's a safe bet the SAD has begun to rear its ugly head, as it's that time of year, so there's that. My appetite has diminished enough that I'm basically back on track for following the post-bariatric surgery diet that I'd gotten away from after having had the surgery in 2015."

• dmr...
• November 12, 2009

"This was not for me. I took this with Lexapro, and my depression worsened, and also I experienced severe mood swings. Became very angry and easy to fly off the handle. Thoughts of suicide were more frequent. I stopped taking it after 5 weeks and noticed an almost immediate improvement in my behavior and how I felt."

• KPa...
• Taken for less than 1 month
• August 4, 2021

"I was recently put on Aplenzin, and I can honestly say I would rather deal with my depression without meds than deal with the side effects. I have been nauseous with no relief and have had a tension headache for 10 days now. It has helped to an extent, but I have felt so ill that the cons outweigh the pros."

• Liz...
• Taken for less than 1 month
• September 28, 2021

"I’ve been taking Aplenzin for 3 weeks, and I have only noticed sharper concentration, smarter conversation, and slight dizziness."