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Exparel User Reviews & Ratings (Page 2)

Exparel has an average rating of 5.7 out of 10 from a total of 73 reviews on Drugs.com. 49% of reviewers reported a positive experience, while 47% reported a negative experience.

Reviews for Exparel

Commonly mentioned side effects
  • Ken...
  • Taken for less than 1 month
  • October 31, 2019

For Pain "I was in the post-op recovery room after having olecranon fracture reconstructive surgery and was having trouble managing the pain. They recommended the Exparel one-time injection, which under the circumstances I readily agreed to. It was administered in the upper pectoral/left shoulder region. I was told that the pain relief would last two days. It relieved the pain, but for only 6 hours."

5 / 10
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9 Report
  • MZa...
  • Taken for less than 1 month
  • August 4, 2021

For Pain "Was given Exparel for shoulder surgery along with another block. I was told it would last up to 96 hours. Following surgery, when I woke up, I experienced breakthrough pain and was given Fentanyl before leaving the surgery center. I was home by 11:00 and still experiencing pain, so I took my prescribed Dilaudid. Less than 11 hours after surgery, the block had completely worn off. I experienced significant pain (10/10) that night and the next morning. The surgery center called, and after speaking with me about my pain, suggested I call my doctor, who then prescribed morphine sulfate (immediate release), which is now helping. Haven’t had a BM since Sunday (and this is Wednesday). Worked no better for me than my normal block (I’ve had 9 wrist/hand surgeries, and this is my 10th surgery in my torso area). 1/10. Not a good experience."

1 / 10
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6 Report
  • Mob...
  • Taken for less than 1 month
  • February 23, 2022

For Pain "Absolute waste of money. I had two exact procedures done. One without Exparel and the other one with, and it made no difference. I spent an additional $650 thinking it would lessen the pain, and it did absolutely nothing, you might as well just take a Tylenol."

1 / 10
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5 Report
  • Jen...
  • Taken for less than 1 month
  • March 13, 2021

For Pain "I was given Exparel while under sedation for surgery. I had a very negative reaction to it upon waking up in the hospital. It made my entire left side go numb, including parts of my face (the injection site was my pelvis). My limbs were shaking uncontrollably, it made me extremely warm then cold - my temperature wouldn’t regulate correctly, it caused ringing in my ears, weakness, and a sensation like I was going to die. It was akin to a very severe anxiety attack. The worst part is that I am five days post-op, and it is still happening even though the drug is supposed to be completely out of my system by now. I wish someone had told me ahead of time that this was going to be administered to me."

1 / 10
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7 Report
  • CDK...
  • Taken for less than 1 month
  • July 1, 2022

For Pain "Horrible drug! Please ask your doctor before any surgery if this will be used. It is a neurotoxin and will destroy your nerves! Nerves should never be deadened for that long! Two years post-abdominal surgery and still have neurologic/muscular problems, and there are no doctors to help you, as they don’t know how to help! Scary!!!"

1 / 10
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4 Report

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  • Sho...
  • Taken for less than 1 month
  • August 25, 2022

For Pain "Was given Exparel as a “nerve block” during rotator cuff/shoulder surgery. Was told it would last up to 96 hours, however, I was pain-free for only about 20 hours. During that time, my arm got very hot, and I had lots of twitching. The worst part was the dead feeling in my arm, it was completely dead and just hung in my sling, and it was falling out of my sling. I even hit my shoulder on a door frame because I couldn’t feel it! In my opinion, it was not worth it to have this injection, and I would refuse it a second time."

2 / 10
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4 Report
  • kri...
  • Taken for less than 1 month
  • June 2, 2021

For Pain "I had a full rotator cuff tear, also ended up with a slap tear and bone spurs to be operated on in my right shoulder. I read horror stories about pain management after this surgery, so I was naturally very anxious. I asked my doctor about Exparel. She had never used it but agreed. I woke up from surgery, and my whole arm was numb, yes, my hand too, but I’ll pay that price any day. It continued to stay numb all the way through my first therapy appointment, in which my therapist was shocked that I couldn’t feel a thing as he manipulated my arm. That was 5 days after surgery. I was able to use very little pain medicine once I got feeling back. I am so thankful this worked so well for me. I just wish it had for everyone, because it can be a game changer."

10 / 10
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6 Report
  • Vis...
  • Taken for less than 1 month
  • May 18, 2023

For Pain "266 mg Exparel. Bilateral inguinal hernia. From recovery room to 24 hours later, my pain has been 8-9 out of 10. Had to ask for a painkiller immediately in recovery. Another (opioid) before leaving the surgical center. By the time I got home, I could barely walk from pain. I would never use this med again. I had laparoscopic gallbladder surgery 2 years ago. Extra strength Tylenol. This laparoscopic procedure, which was less invasive, I've had 4-5 times the pain. I believe Exparel contributed somewhat to it."

1 / 10
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3 Report
  • Hap...
  • Taken for less than 1 month
  • November 11, 2023

For Pain "I was given this medication for rotator cuff surgery. It has now been 24 hours and I have experienced absolutely no pain. I actually feel like I haven't even had any surgery because I have no pain. I was told before the injection that it does not work for everyone. I feel blessed. It has worked for me. I highly recommend receiving this injection."

10 / 10
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2 Report
  • Exp...
  • Taken for less than 1 month
  • May 16, 2019

For Pain "I had a vestibulectomy and was terrified of the recovery. All I have to say is wow. Exparel was a miracle. I had no pain for a week after. By the time Exparel wore off, all I needed was ibuprofen. This drug has made me no longer fear the aftermath of surgery. Just had a wrist surgery and requested the doctor use it. It’s only 24 hours out, but again I have no pain. Bonus points in that my insurance covered it!"

10 / 10
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8 Report
  • Aly...
  • Taken for less than 1 month
  • February 17, 2015

For Pain "I had a rhinoplasty with turbinate reduction this past Friday, and my doctor used Exparel on me. When I woke up, I had no pain or discomfort, and it wasn't until Monday (just about 72 hours after surgery) that I started to feel a headache and some pressure. I honestly couldn't believe the results. To not have any pain after a rhinoplasty was so surprising to me, and now I am just dealing with swelling/bruising that is regular. I did supplement Exparel with Percocet, so I'm sure the two together were helpful, but I wouldn't go through any other procedure like this without it."

10 / 10
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12 Report
  • Vin...
  • Taken for less than 1 month
  • June 16, 2021

For Pain "I just had a hemorrhoidectomy, and the postoperative pain is negligible. I am taking other pain medication for cancer, but so far I haven’t needed much. This is relatively new, can’t wait until they enhance the technology and find a way to use it for chronic pain."

10 / 10
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6 Report
  • Anonymous
  • Taken for less than 1 month
  • January 21, 2020

For Pain "Exparel was a huge blessing for me when I had a hemorrhoidectomy and also helped with the pain of my spinal cord stimulator explant. For the explant, they used it in the outer areas of the surgery, not in the spinal cord area, but for the outer parts of the incisions. Pain control was so much better with Exparel vs. without it. I never want to ever have any surgery without having Exparel. I did require some opioid pain relief but thoroughly believe that if I had not had the Exparel, the pain from both surgeries would have been much worse, requiring much more opioid medication. I think the healing actually went quicker for me because I didn't come out of surgery in extreme pain and felt like moving other parts of my body sooner, which I think brought better blood circulation to the surgical sites."

10 / 10
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6 Report
  • Ann...
  • February 21, 2018

For Pain "I had 2 surgeries down in my lady parts. A lot of stitches. I woke up in recovery and surprisingly NO PAIN!! I felt pressure and a sort of discomfort. I could handle it. Wear the armband (in case you have to go to the ER, it alerts the staff you have had this medicine) for 96 hours. Why aren't ALL doctors using this??? A long-acting numbing injectable in the site where you had surgery. This is an absolute miracle medicine. I have had NO side effects. Ask your doctor about this if you have to have surgery."

10 / 10
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10 Report
  • atd...
  • Taken for less than 1 month
  • June 24, 2024

For Postoperative Pain "I love it. I had a tummy tuck today, and although there is pain because they had to cut out a fairly large area, the majority of my pain is coming from my sides where I had the lipo. Not the tummy, because of this medicine. It's a miracle worker. If I ever have another surgery, this is 100% needed. But I have no idea how it would help a tooth. The jaw, on the other hand, makes sense. He also put it directly into my muscles, so that helps a lot."

10 / 10
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1 Report
  • HG-...
  • Taken for less than 1 month
  • November 19, 2022

For Pain "I have post laminectomy single level with wires and pain stimulator removed. This non-opioid drug did nothing for my postoperative pain. I experienced the following symptoms: extreme pain lasting over 24 hours, rapid heart rate, elevated blood pressure, constipation, dark stool, pain on my right side in the area of my gallbladder, hepatic duct, common bile duct, and pancreas."

1 / 10
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2 Report
  • CBC...
  • Taken for less than 1 month
  • May 19, 2022

For Pain "Terrible drug! It was given without my knowledge during a laparoscopy… injected into my hypogastric nerves during surgery. My lower body up to my chest was numb for over a month. I still have many neurologic symptoms, and it has been 2 years since this was injected into me. Not enough data on this drug! You never want your nerves deadened for that long! Horribly life-changing!"

1 / 10
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3 Report
  • Jim...
  • Taken for less than 1 month
  • January 25, 2024

For Postoperative Pain "My husband had hemorrhoid surgery and had to throw away the narcotics given due to only taking maybe 3 randomly after surgery. He said his pain was not bad after surgery and we had been told it was going to be really bad. Exparel is so good our son invested in stocks! Great stuff!!"

10 / 10
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1 Report
  • Non...
  • Taken for less than 1 month
  • September 7, 2023

For Pain "Was injected with Exparel after my fistulectomy surgery and I've been pain-free since waking up from surgery 14 hours ago and counting. Honestly, it has worked so well that I forget I even had surgery. Somewhat worried about what the pain will be like when it wears off."

10 / 10
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1 Report
  • Bob...
  • Taken for less than 1 month
  • June 20, 2023

For Pain "I was given Exparel for abdominal surgery, and it worked great. However, 12 hours later, the effects wore off, and I was in extreme pain. Does the $3 generic last 8 hours? Not worth it. I had a max dose."

1 / 10
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1 Report
  • Het...
  • Taken for less than 1 month
  • June 17, 2023

For Pain "I received Exparel during a total hip replacement. It did not take more than the slightest edge off the pain. In recovery, it made me so nauseous that the alternative-an opioid-could not be kept down. That put me in that nasty place of trying to catch up with the pain. It is only day 1, and I will amend this if it changes. But I am at about a 7 with the opioid, icing, and elevation. Gonna be a long night."

3 / 10
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1 Report
  • GM ...
  • Taken for less than 1 month
  • February 22, 2018

For Pain "I had a hip labral tear repaired and resurfacing of my femur. I waited for the pain to show up after surgery, and it never did. I did not have to take a single pain pill, which was especially helpful since I have mast cell disease, and narcotics can cause serious allergic reactions. This medication is amazing."

10 / 10
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5 Report
  • Ran...
  • May 22, 2018

For Pain "Exparel is incredible. I have chronic pain that cannot be cured. If I have an injection of Exparel, I feel fantastic for days. Regular bupivacaine lasts only 12 hours - I am on day 2 of Exparel now, and my pain is 1 out of 10. It is usually a 6! Loving this right now, but worried how bad I will feel when it wears off."

10 / 10
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6 Report
  • Pil...
  • Taken for less than 1 month
  • June 12, 2020

For Pain "I was given Exparel after a pilonidal cyst removal and lift procedure. It has worked great. I only took one opioid pain pill just in case the first night of sleep. I did not even need it. I never took another and had absolutely no pain. Although it’s 7 days since surgery, I am still numb. It has worn off some, but I still think I’m about 50 percent numb. Hope it eventually wears off."

10 / 10
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  • But...
  • Taken for less than 1 month
  • November 2, 2021

For Pain "I am just now 96 hours after double hernia repair done robotically in a trauma surgical center. Fantastic care and the first use of Exparel on me worked fantastically. Other than a Tylenol once in a while, I have had no need for an opioid pain relief. I required some intestinal rearrangement and hernia patches resulting from a fall. Due to cancer and an accident, I have had a number of surgeries over the years that I'm sure I could have benefited from Exparel. One of those specifically would have been rotator cuff repair, done on a very damaged shoulder. I've been using that pain for my gauge as a number 10 on the pain scale for many years. I certainly will ask for it again if I require further surgery. Very effective for me."

10 / 10
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1 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.