Vyleesi for Hypoactive Sexual Desire Disorder User Reviews

• RGa...
• Taken for less than 1 month
• May 28, 2022

"I have been struggling with HSDD for years. The thought of my husband touching me repulsed me. I tried Addyi, it didn’t work. I’ve tried everything. I tried Vyleesi tonight for the first time, and I am so relieved that it WORKED! Here’s my experience: I took it at 9:00 PM. Right away, I was nauseous, but it went away within a few minutes. About 15 minutes later, I started to feel the need to stretch my whole body out, and oh did it feel good. Over the next hour, I was laying in bed, having these amazing stretch sessions just waiting to feel some tingly sensations of arousal. Well, around 10:45 PM, I had to pee, so I went to the bathroom. When I wiped, I felt a tingly sensation “down there.” When I got back in bed, I told my husband, “I think it’s starting to work, I have faith.” He then proceeded to touch my body (which I usually hate), and it kickstarted everything! Sex felt better than I ever remember!"

• Yod...
• November 18, 2020

"I had a Vyleesi injection in my leg because of my libido problems. I felt like I was going to puke but only for a few seconds. I waited 45 minutes then headed to my boyfriend's house. By the time I got to his house I was keen for some action! We did it for what felt like forever and I was on a never-ending orgasm. This sex serum stayed in my system all night! He's asleep at 3 AM and I'm over here about to give him the best wake-up call of his life. Take a little pain in the leg for some amazing pleasure."

• bri...
• Taken for 1 to 6 months
• October 19, 2022

"I have struggled with HSDD for a while due to sexual assault in my childhood. I know this isn't for people who have struggled with that, however, Addyi was not working and never worked for me. I have shot anxiety, so when I tell you I couldn't feel this at all, I really mean it. I didn't even feel a pinch from the needle because it's just that small. Pros: - It works. - I actually wanted to have fun with my husband instead of being annoyed that he was touching me. - It lasted for almost 3 days, there's not a definitive time frame that it lasts as everyone is different. - It arrived within one day. Cons: - The first dose will make you nauseated. Dramamine and Zofran didn't help at all."

• lee...
• Taken for less than 1 month
• March 7, 2023

"I am a 49-year-old woman suffering from low libido for the past 5 years. I know every woman's body responds differently to medications, so I paid no mind to the negative reviews that stated, 'Don't waste your money.' I was desperate for help, not to mention my husband was also. I tried Vyleesi for the first time last week. I was surprised that I did not feel any nausea at all. I did, however, feel the need to stretch constantly once it kicked in. I read to wait 45 minutes, and in reality, it took me personally 1.5 to 2 hours before I felt any effects. Once it kicked in, it was amazing. I had sensations I haven't felt since I was a teenager. It was worth the endless stretching. It did not keep me awake or put me to sleep, as some reviews state. The effects lasted me about 12 to 18 hours (I woke up and was still feeling tingly down there). I will definitely use it again."

• Mis...
• Taken for less than 1 month
• March 28, 2025

"I’m 45 years old, and while I feel incredibly attracted to my handsome husband, I’ve been struggling with my desire, which has definitely affected my mental health. I’d love to share my experience with Vyleesi! Just a week ago, after a lovely dinner out, I decided to take the shot. To help with nausea after hearing all the reviews, I took a Zofran at the same time. Thankfully, that helped because I felt a bit off for a little while. Eventually, I drifted off to sleep since we were out of town after a long day. But guess what? When I woke up the next morning, I felt like I was 20 again! It was such an incredible experience—this shot doesn’t just get the 'juices' flowing; it truly fires up that part of our brain that shouts 'Desire!' I felt alive, and I felt so sexy! It was simply amazing! I tried it again last night in the same way, but sadly, I didn’t feel anything this time. I’m a bit disappointed, but I’m ready to try again!"

• Ms ...
• Taken for 6 months to 1 year
• September 1, 2023

"It DEFINITELY works. It’s been around globally for many years and is available in other countries for both women and men (not under the name Vyleesi, but as PT-141 - look it up). The needle is insignificant as it's so tiny you don’t even feel it at all. It does make some feel nauseous preliminarily for a short while (laying down helps) and this could make some overly sensitive types shy away from it. (The initial nausea goes away with repeat usage.) But once that subsides - look out! Its effects last up to 24 hours and can take up to 2-3 hours to really kick in. Many use it reliably for occasional sexual escapades. It’s pretty intense so I don’t use it every time I have sex. But when I do, it makes me feel EXACTLY like I did when I was in my teens and early 20s—super horny! It elicits that kind of state where your burning desire WILL override your inhibitions—repeatedly. ;-) Affects men the same way. Amazing stuff. Finally, an aphrodisiac that works."

• Bro...
• Taken for less than 1 month
• March 5, 2023

"I am coming up on my golden years, and as of 4 years ago, my desire for physical touch by my husband repulsed me. I was desperate to get that desire back. I got a rx for Vyleesi and was a good candidate. Despite the side effects that were noted, I know everyone’s body responds differently, so I was not concerned about that. I was expecting nausea from what I read but had no nausea at all. I read to take it 45 min before “the moment” when with me … took 2 hours. It started with the continual need to stretch and vulvar sensitivity. After that, I realized I had finally found a way to regain feeling there. The sensation lasted about 18 hours. Fell asleep fine on it. It did not keep me awake. I will definitely continue using Vyleesi. It has been a lifesaver."

• Hor...
• Taken for less than 1 month
• April 4, 2022

"Guys. I'm 13 hours post-injection, and I cannot cross my legs without being turned on. I feel like it definitely did the job, but damn, I gotta work now. My only complaint is that it made me pretty nauseous, and I randomly got heartburn. It didn't hurt at all to inject."

• Ter...
• Taken for less than 1 month
• September 11, 2024

"I happened to have horrible side effects. Within an hour of taking it, I was so sick. Nausea was horrible. I was throwing up and eventually dry heaving. My muscles kept tensing up. It gave me a horrible headache. Fifteen hours later, I am still having these side effects. Feels like the flu, to be honest. However, I will say it works. It does what it says. I just wish the side effects weren’t like this. I probably won’t take it again because of the side effects. If you don’t get the side effects, it’s a miracle shot that you will love. Try it for yourself and see. Everyone is different."

• Mic...
• Taken for 1 to 6 months
• August 28, 2023

"My husband and I had not had sex for over a year, since we had our 3rd child. The injection in my thigh did not hurt at all. I took it about two hours before bed, after which I felt slightly hot and nauseous for a few minutes. About an hour later I was feeling the need to stretch, but the stretching felt good. I also started getting quite aroused, almost like I was 18 again. We not only had sex for the first time in a year, I orgasmed more than I ever have before, and had the best night's sleep. I've now taken it twice more with the same effect. Vyleesi has changed my life. I read that men could also take it and it had the same effect."

• Hai...
• Taken for less than 1 month
• September 24, 2024

"I was extremely nervous to try Vyleesi for the first time. From reading all of the reviews, I wasn’t sure what to expect. Right before the injection, I took some Zofran and Tylenol to hopefully help with any nausea or headache I might get. I took it at about 8:40 PM… About 10 minutes after the injection, I started feeling a little nauseous, but the worst part was how flushed my face was getting, to the point I had to sit in front of a fan with a cold rag. I went ahead and went to sleep, but woke up extremely aroused around 2 AM. Every person's side effects are different, but man oh man, is the end result worth it. It’s 8:10 AM now, and I’m still feeling the arousal (the only issue is now I have to sit at work all day)."

• Pam...
• Taken for less than 1 month
• May 18, 2023

"I took this drug for the first time, and I experienced all the side effects listed: stuffy nose, coughing, extreme nausea, flushing/chills, headache, fatigue, and soreness at the injection site. The symptoms lasted 8 hours. I took Compazine for nausea and finally fell asleep. The next day, the nausea was gone, but I felt fatigued. I stayed in bed most of the following day. I will never use this drug again. My husband and I could not engage sexually because I was so sick from the side effects."

• lik...
• Taken for 1 to 6 months
• November 11, 2020

"Really wanted to want it again like we were in our 20s before the stress of kids, money, and work piled up. It worked amazingly. I was told a large number of people experience nausea, but it was minor."

• Cbr...
• Taken for less than 1 month
• January 21, 2024

"This medicine worked disturbingly well! I nervously took it with the nausea pill and started a relaxation routine right afterwards. I felt minimal nausea and waited anxiously for 2 hours before bed. I could feel the sensation, but it was easily ignored. However, I woke multiple times in the middle of the night with an insatiable sexual urge that had never occurred... It was undeniable and could not be ignored. Not only did it make for a fun night, but it continued throughout the next day. I'm so shocked by how well the medicine worked, and will plan carefully now to administer when there's more time to play."

• Ali...
• April 30, 2023

"I have tried this a few times off and on over the past 1-2 years. Everyone is unique. I do get nauseous and have zero appetite, but not enough to keep me from going out. I’ve used it probably 5-6 times, and it seems to work better and better. I’m 48, been married 27 years, and my drive has decreased. This has made for increased sensitivity. Sex has been really good. I’m not going to use it a ton, but for me, it does work."

• Pre...
• Taken for less than 1 month
• July 24, 2023

"So far, I have taken 1 injection. It didn't kick in after 45 minutes. I ended up going to bed, and when I woke up, it felt like it was working! It wasn't anything crazy or overwhelming, but it definitely worked. I did have a panic when I saw on my insurance portal that I was responsible for $1700!!!! I called the pharmacy, and she confirmed that the patient payment required was only $98 for a 1-month supply!!"

• Anonymous
• Taken for less than 1 month
• September 2, 2023

"I was very concerned about all of the negative reviews, but experienced none of these. I found that it does what it says! It was the first time in over 3 years that I actually enjoyed sex!! My husband and I always had a great sex life until I went through menopause. After I took the injection, I was good! I did take an anti-nausea drug before, not sure if that helped with side effects. I will continue to take this, a life-saving hope for my marriage!! Thanks"

• Its...
• Taken for 1 to 6 months
• July 23, 2022

"I've tried it 4 times. I am not going to order again. My body hurt the next day from all the stretching I felt I needed. It did make me sensitive in my clitoris area, almost too much so. But I also got a cough and vomited twice. So I'd say it didn't work the way I had hoped it would."

• Kri...
• Taken for 1 to 6 months
• November 12, 2021

"Ok, my late 40s has been challenging with entering pre-menopause and lack of sex drive. I am on HRT, and it's helped a little with sex drive but not enough. I am single and dating. The NP at the hormone clinic wrote me this when I asked her to. It's expensive, and insurance won't cover it, but I qualified for some coupon for one supply, which had 4 pens in it. It's easy to use-remove cap and press against your thigh or buttock and press down and hold for 10 secs. Ok, now the big question-does it work? Well, first, I need to take this a good 3 to 4 hrs before sex, not 20 or 30 mins. Major sensitivity in the clitoral area for a good 24 hrs after, so be prepared. Did it make me horny? Not really. I also tend to have trouble sleeping when I take this, it's weird. So overall, I haven't noticed any real side effects and will likely order again, though I'm not sure how I'm going to pay for it."

• Ano...
• Taken for less than 1 month
• November 12, 2023

"Excellent response within 2 hours of injection. Felt horrible the rest of the day though - nausea and diarrhea. May have been a bug though. Only used it once so not sure. Honestly though, totally worth it for the response I got."

• UNK...
• Taken for less than 1 month
• February 10, 2025

"I read every single review before my first dose and was, to say the least, nervous. I read about nausea, vomiting, weakness in legs, etc. It sounded awful. Why would I do this to myself? Well, I hoped for an increase in libido. Short answer, this may not exist. The first dose I took, I experienced some nausea, lack of appetite, my legs felt different, but not bad. My clitoris was very enlarged and sensitive, but almost too sensitive. I decided to try another dose. Big mistake. It was like the 24-hour flu. I napped on and off through the day, throwing up in between naps. It was awful. Not to mention an enlarged and sensitive clitoris, which was miserable. I am not one prone to sickness with meds. This was terrible with zero benefit."

• mur...
• Taken for less than 1 month
• August 13, 2020

"It did work quite well, but caused a headache after an hour or so, which subsided after a couple of hours."

• DCa...
• Taken for 1 to 6 months
• September 23, 2020

"Every woman and possibly men should know about Vyleesi. Easy to use, results were more than we expected. Highly recommend."

• Na2...
• Taken for less than 1 month
• May 12, 2023

"Amazing. I felt alive and felt everything. It did not take effect the same day for me, it hit me the next day. But I am not complaining. Way better than Addyi, that med made me sick as a dog."

• Anonymous
• September 17, 2020

"A true lifesaver. Thank you!"