Amitriptyline for Burning Mouth Syndrome User Reviews

• Anonymous
• December 8, 2008

Amitriptyline "I was very skeptical that an antidepressant would help with my persistent burning mouth syndrome. My symptoms were severe: burning tongue, roof of the mouth, and throat. After many tests and no results, my doctor suggested amitriptyline. It worked almost immediately, and after two weeks, almost all the pain is gone. The side effects are minimal: dry mouth and disturbed dreams, which seem to have diminished after a month or so. It's worth it for me."

• San...
• Taken for 5 to 10 years
• March 27, 2017

"I have suffered from Burning Mouth Syndrome now for 7 years; it literally possessed my mouth like a fiery demon one day, and I have suffered on and off from it ever since. After trying numerous ineffective treatments, I was prescribed amitriptyline (Endep 25) by an oral pathologist. It works to a point, and also helps with the chronic insomnia I have experienced for 10 years. However, I don't like taking this drug; I feel like a zombie the next day, and it takes a whole day to get over the feeling. However, I like to keep a supply on hand for when the BMS becomes unbearable; I'll actually 'knock myself out' with Endep to obtain relief when my symptoms are really severe. More research is needed urgently into this nightmarish condition!"

• lel...
• Taken for less than 1 month
• November 16, 2013

"Miracle for me! I have burning pain in my mouth and vulvodynia. I have been on this for 3 days and almost no pain. I had heavy side effects of dizziness and was lethargic the first 2 days but am coming out of it now. Taking 25 mg twice daily."

• Bij...
• Taken for 2 to 5 years
• August 1, 2020

"My GI doctor prescribed this drug, amitriptyline, for burning mouth and other symptoms - poor sleep, loose bowels. It immediately helped me sleep, and I took it without much problem for a year, although my burning mouth syndrome (BMS) over this period got slowly worse. When I tried to wean off of it, lo and behold, my mouth felt so moist and my burning mouth improved immediately. Unfortunately, it created havoc in my stomach with acid rebound, and I had to go back on it to wean off very slowly. Apparently, amitriptyline can also cause burning mouth. Taking this drug was one of the worst decisions of my life."

• Tkm...
• Taken for 1 to 2 years
• January 6, 2025

"Positive experience, but my Australian specialist prescribed only 1 mg Endep (Amitriptyline) as a mouth rinse, dissolved 1/2 of a 2 mg tablet, swish around mouth for 1-2 min, then expel. This has improved my condition but not completely cured it. I sleep better at night (only do this rinse at night) because my mouth stops burning. I still have a dry mouth throughout the day, but it has improved a little, and the burning is on and off. I’ve been told it’s a permanent condition and can’t be cured. Would love someone to do more research into treatment and possible cure for this condition as more needs to be done! Also, no side effects for me."

• JB2...
• December 11, 2013

"Male with burning mouth syndrome. It took a few weeks, but this did subdue the symptoms. 50 mg nightly."

• Rac...
• Taken for 2 to 5 years
• October 3, 2021

"NEGATIVES - sore mouth, tongue, and mouth ulcers, and drowsiness the following day. POSITIVES - guaranteed sleep when in pain."

• Hir...
• Taken for less than 1 month
• February 22, 2022

"Very bad way to sleep... And very irritated feeling."

• bur...
• Taken for less than 1 month
• December 17, 2019

"I have tried amitriptyline 50 mg nightly for three weeks, not helping. In addition to that, am taking zinc and rinsing with oregano oil."