Transaminitis
Medically reviewed by Drugs.com. Last updated on Apr 6, 2025.
What is transaminitis?
Transaminitis is a high level of certain enzymes in your blood called transaminases. These include alanine transaminase (ALT) and aspartate transaminase (AST). These enzymes are produced by your liver. They are also called aminotransferases. Enzymes help break down nutrients for your body to absorb and filter toxins out of your body. When there are too many in the liver, they start to move into the bloodstream. These high levels may be an early sign of liver disease, damage, or inflammation.
What is an elevated transaminase level?
The specific level depends on several factors such as your age, sex, and body composition. In general, the range may be from 10 to 40 units per liter. Your healthcare provider will go over your results with you.
What causes transaminitis?
The following are common causes of transaminitis:
- Non-alcoholic fatty liver disease
- Viral hepatitis (eg, hepatitis A, B, or C) or other viral infections (eg, herpes simplex, Epstein Barr)
- Medical conditions such as hemochromatosis, hypothyroidism, or heart failure
- Alcohol-related liver disease
- Drug-induced liver injury (eg, amoxicillin, acetaminophen, antidepressants)
- Trauma or damage to the liver, or skeletal or heart muscle
What are the signs and symptoms of transaminitis?
Transaminitis does not cause symptoms on its own. You may have signs or symptoms associated with a liver condition. These may include jaundice, upper abdominal pain, or bruising and bleeding easily.
How is transaminitis diagnosed?
Your healthcare provider will ask about your medical history and symptoms. Tell the provider about any medicines you take, including over the counter medicines or supplements.
- A blood test called a liver function test will measure your transaminase levels and check how well your liver is working.
How is transaminitis treated?
Treatment depends on what is causing the elevated enzymes. You may need antiviral medicine, removal of a medicine causing liver damage, or treatment of a liver injury.
When should I call my doctor?
- You have questions or concerns about your condition or care.
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