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Ruxolitinib

Generic name: ruxolitinib [ RUX-oh-LI-ti-nib ]
Brand name: Jakafi
Dosage form: oral tablet (10 mg; 15 mg; 20 mg; 25 mg; 5 mg)
Drug class: Multikinase inhibitors

Medically reviewed by Drugs.com on Mar 2, 2023. Written by Cerner Multum.

What is ruxolitinib?

Ruxolitinib is used in adults to treat myelofibrosis or polycythemia vera, which are bone marrow disorders that affect your body's ability to produce blood cells.

Ruxolitinib is also used to treat graft versus host disease in adults and children at least 12 years old.

Ruxolitinib is usually given after other treatments have failed.

Ruxolitinib may also be used for purposes not listed in this medication guide.

Ruxolitinib side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may be similar to the symptoms of myelofibrosis. Call your doctor at once if you have:

Common side effects of ruxolitinib may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Follow all directions on your prescription label and read all medication guides or instruction sheets. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

You should not use ruxolitinib if you are allergic to it.

Tell your doctor if you have ever had tuberculosis or if anyone in your household has tuberculosis. Also, tell your doctor if you've had or been exposed to tuberculosis, or if you recently traveled. Some infections are more common in certain parts of the world, and you may have been exposed during travel.

Tell your doctor if you have or have ever had:

It is not known if ruxolitinib will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breastfeed while using ruxolitinib, and for at least 2 weeks after your last dose.

Ruxolitinib is not approved for the treatment of myelofibrosis or polycythemia vera by anyone younger than 18 years old.

How should I take ruxolitinib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Your doctor may occasionally change your dose. You will need frequent medical tests to help your doctor determine the best dose.

You may take ruxolitinib with or without food. The ruxolitinib tablet can also be given through a nasogastric (NG) feeding tube.

Read and carefully follow any Instructions for Use provided with the medicine. Ask your doctor or pharmacist if you do not understand these instructions.

If you are on dialysis, ruxolitinib should be taken after your dialysis.

Using ruxolitinib may increase your risk of developing other cancers. Ask your doctor about this risk.

Store at room temperature away from moisture and heat.

You should not stop using ruxolitinib suddenly. Follow your doctor's instructions about tapering your dose.

You may be given other medications to help prevent infection. Keep taking these medicines for as long as your doctor has prescribed.

prednisone, methotrexate, Deltasone, imatinib, Jakafi, Imbruvica, ibrutinib, Gleevec, Ojjaara, momelotinib

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking ruxolitinib?

Grapefruit may interact with ruxolitinib and cause side effects. Avoid consuming grapefruit products.

What other drugs will affect ruxolitinib?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Tell your doctor about all your other medicines, especially fluconazole.

This list is not complete and many other drugs may affect ruxolitinib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Does ruxolitinib interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.