Generic name: Hydrocodone and Ibuprofen [ hye-droe-KOE-done-& eye-byoo-PROE-fen ]
Brand names: Ibudone, Reprexain, Vicoprofen, Xylon
Drug class: Narcotic analgesic combinations

Medically reviewed by Drugs.com. Last updated on Mar 29, 2024.

Uses of Reprexain:

• It is used to ease pain.

What do I need to tell my doctor BEFORE I take Reprexain?

• If you have an allergy to hydrocodone, ibuprofen, or any other part of Reprexain (hydrocodone and ibuprofen).
• If you have an allergy to aspirin or NSAIDs.
• If you are allergic to Reprexain (hydrocodone and ibuprofen); any part of Reprexain (hydrocodone and ibuprofen); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
• If you have any of these health problems: Lung or breathing problems like asthma, trouble breathing, or sleep apnea; high levels of carbon dioxide in the blood; or stomach or bowel block or narrowing.
• If you have any of these health problems: GI (gastrointestinal) bleeding or kidney problems.
• If you have had a recent heart attack.
• If you are taking any other NSAID.
• If you are taking a salicylate drug like aspirin.
• If you are taking pemetrexed.
• If you are taking any of these drugs: Buprenorphine, butorphanol, nalbuphine, or pentazocine.
• If you have taken certain drugs for depression or Parkinson's disease in the last 14 days. This includes isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. Very high blood pressure may happen.
• If you are taking any of these drugs: Linezolid or methylene blue.
• If you are having trouble getting pregnant or you are having your fertility checked.
• If you are pregnant or may be pregnant. Do not take Reprexain (hydrocodone and ibuprofen) if you are in the third trimester of pregnancy. You may also need to avoid Reprexain (hydrocodone and ibuprofen) at other times during pregnancy. Talk with your doctor to see when you need to avoid taking Reprexain (hydrocodone and ibuprofen) during pregnancy.

This is not a list of all drugs or health problems that interact with Reprexain (hydrocodone and ibuprofen).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Reprexain (hydrocodone and ibuprofen) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Reprexain?

• Avoid driving and doing other tasks or actions that call for you to be alert until you see how Reprexain (hydrocodone and ibuprofen) affects you.
• To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
• You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
• Liver problems have happened with drugs like this one. Sometimes, this has been deadly. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
• This medicine may raise the chance of a very bad brain problem called aseptic meningitis. Call your doctor right away if you have a headache, fever, chills, very upset stomach or throwing up, stiff neck, rash, bright lights bother your eyes, feeling sleepy, or feeling confused.
• The chance of heart failure is raised with the use of drugs like this one. In people who already have heart failure, the chance of heart attack, having to go to the hospital for heart failure, and death is raised. Talk with the doctor.
• The chance of heart attack and heart-related death is raised in people taking drugs like this one after a recent heart attack. People taking drugs like this one after a first heart attack were also more likely to die in the year after the heart attack compared with people not taking drugs like this one. Talk with the doctor.
• A severe and sometimes deadly problem called serotonin syndrome may happen if you take Reprexain (hydrocodone and ibuprofen) with certain other drugs. Call your doctor right away if you have agitation; change in balance; confusion; hallucinations; fever; fast or abnormal heartbeat; flushing; muscle twitching or stiffness; seizures; shivering or shaking; sweating a lot; severe diarrhea, upset stomach, or throwing up; or severe headache.
• Long-term use of an opioid drug may lead to lower sex hormone levels. Call your doctor if you have a lowered interest in sex, fertility problems, no menstrual period (women), or change in sex ability (men).
• Taking an opioid drug like Reprexain (hydrocodone and ibuprofen) may lead to a rare but very bad adrenal gland problem. Call your doctor right away if you have very bad dizziness or passing out, very bad upset stomach or throwing up, or if you feel less hungry, very tired, or very weak.
• If you are 65 or older, use Reprexain (hydrocodone and ibuprofen) with care. You could have more side effects.
• This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking Reprexain (hydrocodone and ibuprofen), call your doctor right away.
• Tell your doctor if you are breast-feeding or plan to breast-feed. This medicine passes into breast milk and may harm your baby.

How is this medicine (Reprexain) best taken?

Use Reprexain (hydrocodone and ibuprofen) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Take with or without food. Take with food if it causes an upset stomach.
• Do not take more than what your doctor told you to take. Taking more than you are told may raise your chance of very bad side effects.
• Do not take Reprexain (hydrocodone and ibuprofen) for longer than you were told by your doctor.
• Tell all of your health care providers that you take Reprexain (hydrocodone and ibuprofen). This includes your doctors, nurses, pharmacists, and dentists.
• If you have been taking Reprexain (hydrocodone and ibuprofen) for a long time or at high doses, it may not work as well and you may need higher doses to get the same effect. This is known as tolerance. Call your doctor if Reprexain (hydrocodone and ibuprofen) stops working well. Do not take more than ordered.
• Long-term or regular use of opioid drugs like Reprexain (hydrocodone and ibuprofen) may lead to dependence. Lowering the dose or stopping Reprexain (hydrocodone and ibuprofen) all of a sudden may cause a greater risk of withdrawal or other severe problems. Talk to your doctor before you lower the dose or stop Reprexain (hydrocodone and ibuprofen). You will need to follow your doctor’s instructions. Tell your doctor if you have more pain, mood changes, thoughts of suicide, or any other bad effects.
• Do not take Reprexain (hydrocodone and ibuprofen) with other strong pain drugs or if you are using a pain patch without talking to your doctor first.
• Have blood work checked as you have been told by the doctor. Talk with the doctor.
• High blood pressure has happened with drugs like this one. Have your blood pressure checked as you have been told by your doctor.
• If you are taking aspirin to help prevent a heart attack, talk with your doctor.
• If you smoke, talk with your doctor.
• If you have asthma, talk with your doctor. You may be more sensitive to Reprexain (hydrocodone and ibuprofen).
• This medicine may raise the chance of seizures in some people, including people who have had seizures in the past. Talk to your doctor to see if you have a greater chance of seizures while taking Reprexain (hydrocodone and ibuprofen).

What do I do if I miss a dose?

• If you take Reprexain (hydrocodone and ibuprofen) on a regular basis, take a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not take 2 doses at the same time or extra doses.
• Many times Reprexain (hydrocodone and ibuprofen) is taken on an as needed basis. Do not take more often than told by the doctor.

Related/similar drugs

acetaminophen, tramadol, cyclobenzaprine, naproxen, oxycodone, Tylenol

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
• Signs of high or low blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
• Signs of high potassium levels like a heartbeat that does not feel normal; feeling confused; feeling weak, lightheaded, or dizzy; feeling like passing out; numbness or tingling; or shortness of breath.
• Trouble breathing, slow breathing, or shallow breathing.
• Chest pain or pressure.
• Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
• Very bad belly pain.
• Any unexplained bruising or bleeding.
• Feeling very tired or weak.
• Change in eyesight, eye pain, or very bad eye irritation.
• Black, tarry, or bloody stools.
• Throwing up blood or throw up that looks like coffee grounds.
• Shortness of breath, a big weight gain, or swelling in the arms or legs.
• Seizures.
• Fever or chills.
• Sore throat.
• A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

What are some other side effects of Reprexain?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Anxiety.
• Feeling sleepy.
• Dry mouth.
• Sweating a lot.
• Feeling nervous and excitable.
• Constipation.
• Upset stomach or throwing up.
• Dizziness.
• Stomach pain or heartburn.
• Feeling tired or weak.
• Not able to sleep.
• Diarrhea.
• Gas.
• Headache.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Reprexain?

• Store at room temperature.
• Protect from light.
• Store in a dry place. Do not store in a bathroom.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer Information Use and Disclaimer

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Reprexain (hydrocodone and ibuprofen) is refilled. If you have any questions about Reprexain (hydrocodone and ibuprofen), please talk with the doctor, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer