Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy, especially alkylating agents such as thiotepa.[1] Labeling suggests that mothers should not breastfeed during therapy and for 1 week after the last dose of thiotepa. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[2] Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.[1]
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
1.
Pistilli B, Bellettini G, Giovannetti E, et al. Chemotherapy, targeted agents, antiemetics and growth-factors in human milk: How should we counsel cancer patients about breastfeeding? Cancer Treat Rev 2013;39:207-11 [PubMed: 23199900]
2.
Urbaniak C, McMillan A, Angelini M, et al. Effect of chemotherapy on the microbiota and metabolome of human milk, a case report. Microbiome 2014;2:24 [PMC free article: PMC4109383] [PubMed: 25061513]
Substance Identification
Substance Name
Thiotepa
CAS Registry Number
52-24-4
Drug Class
Breast Feeding
Lactation
Milk, Human
Antineoplastic Agents, Alkylating
Myeloablative Agonists
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