Drugs containing Loperamide: Imodium, Imodium A-D, Anti-Diarrheal, Imodium Multi-Symptom Relief, Diamode, Pepto Diarrhea Control, Up and Up Anti-Diarrheal Solution, Kaopectate II, Neo-Diaral, Imotil, Show all 15 »Kao-Paverin, Diar-Aid, Kaopectate 1-D, A-D Anti-Diarrheal, Anti-Diarrheal + Anti-Gas
Loperamide Levels and Effects while Breastfeeding
Summary of Use during Lactation
The amount of loperamide that enters milk from a prodrug of loperamide is minimal. Use of loperamide during breastfeeding is unlikely to affect the infant with standard doses.[1,2]
Drug Levels
Maternal Levels. Loperamide has not been studied during breastfeeding, but the loperamide prodrug, loperamide oxide, has been studied in a dosage of 2 doses of 4 mg given 12 hours apart to 6 women 18 to 47 hours after delivery. Median loperamide milk concentrations were 0.18 mcg/L at 12 hours after the first dose, 0.27 mcg/L at 6 hours after the second dose, and 0.19 mcg/L at 24 hours after the second dose.[3]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
1.
Mahadevan U, Kane S. American Gastroenterological Association Institute Technical Review on the Use of Gastrointestinal Medications in Pregnancy. Gastroenterology 2006;131:283-311. [PubMed: 16831611]
2.
Schulze H, Esters P, Dignass A. Review article: The management of Crohn's disease and ulcerative colitis during pregnancy and lactation. Aliment Pharmacol Ther 2014;40:991-1008. [PubMed: 25200000]
3.
Nikodem VC, Hofmeyr GJ. Secretion of the antidiarrhoeal agent loperamide oxide in breast milk. Eur J Clin Pharmacol 1992;42:695-6. [PubMed: 1623917]
Substance Identification
Substance Name
Loperamide
CAS Registry Number
53179-11-6
Drug Class
Breast Feeding
Lactation
Milk, Human
Antidiarrheals
Gastrointestinal Agents
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