Bendroflumethiazide Levels and Effects while Breastfeeding
Summary of Use during Lactation
No information is available on the amount of bendroflumethiazide in breastmilk. Intense diuresis with large doses of bendroflumethiazide can decrease breastmilk production, especially during the neonatal period. Shorter-acting diuretics in low doses are preferred over bendroflumethiazide.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Bendroflumethiazide has been used to suppress lactation in oral doses of 5 mg twice daily for 5 days, and in doses of 10 mg in the morning and 5 mg in the afternoon.[1-3] The added contribution of the diuretic to these measures, which are effective in suppressing lactation, has not been studied. There are no data on the effects of potent diuretics on established, ongoing lactation.
Healy M. Suppressing lactation with oral diuretics. Lancet 1961;277:1353-4. doi:10.1016/S0140-6736(61)90289-6 [CrossRef]
2.
Stout G. Suppression of lactation. Br Med J 1962;1:1150.
3.
Reiher KH. Suppression of lactation by stimulation of diuresis. Zentralbl Gynakol 1963;85:188-90. [PubMed: 13973786]
Substance Identification
Substance Name
Bendroflumethiazide
CAS Registry Number
73-48-3
Drug Class
Breast Feeding
Lactation
Milk, Human
Antihypertensive Agents
Thiazide Diuretics
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