Articaine use while Breastfeeding

Summary of Use during Lactation

Based on the low excretion of articaine into breastmilk, a single dose of articaine injected during breastfeeding is unlikely to adversely affect the breastfed infant.

Drug Levels

Maternal Levels. Two mothers donated 3 mL of breastmilk before 68 mg of articaine injection for dental anesthesia and at 15 and 30 minutes, 1, 1.5, 2 and 3 hours after administration. Peak milk articaine concentrations of 237 and 270 mcg/L occurred 15 minutes after administration and fell to about 10 mcg/L by 3 hours after the dose.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1.

Liu S, Wu X, Liu D, et al. Development and application of a quantitative LC-MS/MS assay for the analysis of four dental local anesthetics in human plasma and breast milk. J Chromatogr B Analyt Technol Biomed Life Sci 2025;1250:124384. [PubMed: 39577311]

Substance Name

Articaine

CAS Registry Number

23964-58-1

Drug Class

Breast Feeding

Lactation

Milk, Human

Anesthetics, Local