Artiss

Generic name: fibrin sealant topical [ FYE-brin-SEE-lant-TOP-i-kal ]
Drug class: Miscellaneous coagulation modifiers

Medically reviewed by Drugs.com. Last updated on Aug 7, 2023.

What is Artiss?

Artiss is made of two substances from human plasma that work together to help your blood clot.

Artiss is used to help control bleeding during surgery when other ways to close a wound or incision (such as stitches, bands, or heat) cannot be used. Fibrin sealant may also be used to prevent leaks from a wound left in stomach tissue after a colostomy is removed.

Artiss is sometimes used to help skin tissues stick together during skin graft procedures or cosmetic surgery.

Warnings

You should not be treated with Artiss if you are allergic to cows or products made from cows.

Artiss is made from human plasma (part of the blood) and may contain infectious agents (e.g., viruses) that can cause disease. Although Artiss is screened, tested, and treated to reduce the possibility that it carries an infectious agent, it can still potentially transmit disease. Discuss with your doctor the risks and benefits of using Artiss.

Contact your doctor if you develop fever, drowsiness, chills, runny nose, rash, joint pain, poor appetite, tiredness, nausea, vomiting, abdominal pain, dark-colored urine, or yellowing of the skin or eyes following treatment with Artiss. These may be symptoms of infections that may occur due to use of this product.

Before taking this medicine

You should not be treated with Artiss if you are allergic to cows or products made from cows.

It is not known whether Artiss will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether fibrin sealant topical passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I use Artiss?

Artiss can be sprayed or dripped onto the affected skin or surgical area. This medicine is applied by a healthcare professional in a surgical or clinical setting.

Artiss is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

Some people develop symptoms of a viral infection after being treated with Artiss. Call your doctor if you have flu-like symptoms such as fever, chills, drowsiness, or a runny nose. You may also have joint pain and a skin rash about 2 weeks after the start of your flu symptoms.

Related/similar drugs

thrombin topical, Thrombin-JMI, Thrombi-Gel, Tisseel, VistaSeal, Evarrest

What happens if I miss a dose?

Because you will receive Artiss in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Since this medicine is applied by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after being treated with Artiss?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Artiss side effects

Get emergency medical help if you have any signs of an allergic reaction to Artiss: hives, itching, warmth, redness, numbness, tingly feeling; nausea, vomiting, feeling light-headed, fast or slow heartbeats; wheezing, chest tightness, trouble breathing; swelling of your face, lips, tongue, or throat.

Fibrin sealant is sometimes applied with a spray device that uses gas pressure. High pressure may cause the release of air or gas under the skin tissues, where it can then travel throughout the body. This may be more likely when high pressure settings are improperly used by a healthcare provider during the spray application of fibrin sealant. Air or gas trapped within the body can cause serious or life-threatening effects. Talk with your doctor about this risk.

Tell your caregivers at once if you have:

• chest pain, cough, trouble breathing, gasping for breath;

• confusion, agitation, panic, extreme fear;

• sudden numbness or weakness (especially on one side of the body);

• sudden severe headache, slurred speech, problems with vision or balance;

• blue-colored appearance of your skin or lips;

• nausea, dizziness or spinning sensation;

• a light-headed feeling, like you might pass out; or

• redness, itching, irritation, or slow healing of the skin wound or treated area;

Common Artiss side effects may include:

• itching; or

• swelling or bruising.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Artiss?

It is not likely that other drugs you take orally or inject will have an effect on topically applied fibrin sealant. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Artiss only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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