I woke up in the middle of the night and started feeling a lot of negative thoughts. I started to cry uncontrollably. I have been on Zoloft for 2 weeks and just experience this feeling twice. I have been in a very depressive mood but this was out of the norm. Can Zoloft cause this reaction? I'm on 25 MG and also taking wellbutrin, lamictal and a high blood pressure medication. Is this one of the side effects? Extreme Crying sometimes?