Hi. I’m now trying my 3rd antidepressant, Zoloft but only 12.5mg. Has anyone else taken this low of a dose & if so did it help depression? I’m very sensitive to all meds. Any advice would be appreciated!
Zoloft 12.5mg will a low dose do anything?
Question posted by crazygirl66 on 10 May 2018
Last updated on 3 January 2024 by Amy289
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7 Answers
25 mg made me so anxious and worried about so much. 12.5 is better!!
I have been taking 12.5 mg of Zoloft for some time and doing pretty well. I am elderly and with 25mg I was not full alert. The 12.5 dose does provide me with moderate (but not full) relief from my depression and anxiety. I would recommend it for anyone who is sensitive to SSRI medications
I started on Wellbutrin and broke out in a rash, then the doc switched me to Effexor which I was having horrible side effects. I'm on Zoloft now for about 2 weeks on 12.5mg to see if I can tolerate it. I've been WAY more level and sometimes "zone out", but I'm not suicidal so the trade off is currently worth it! I may go up to 25mg depending on what doc wants to do.
@NewGuy47. 25mg is all I can take. Been on this dose for over 6 months now. I couldn’t take 50mg because I couldn’t stay awake, 25mg also makes me less motivated but it does help my depression. Tried Wellbutrin also to help with energy but just made me feel terrible.
YES. I was on 12.5 mg of Zoloft for 3 months. Within a month I was way happier, way less obsessive-compulsive, stopped binging and purging, loved smoking cigarettes, BUT i had to sleep for 14 hours a day and it lowered my sex drive. If you have a strong reaction to Zoloft at 12.5 mg like I did, then I suggest also being put on the lowest dosage of Wellbutrin which will fix the need to sleep so much, sex drive, and craving for cigarettes.
12.5 mg of Zoloft will do nothing. The starting dose is 25mg.
I took 25mg today, will see what happens. Although I did fall asleep after lunch for awhile, could be the drug or just me...
Remember that every medication affects every individual differently. See how it goes for you... your doctor can always increase your dosage along the way IF you tolerate the medication and IF an increase is clinically indicated.
I am very sensitive to medication as well. I have never taken zoloft but the two medications I do take I am on the lowest dose available and they function fine. When they tried to raise the dose my body could not tolerate it. In essence it is better to try a low dose and see how your body reacts to it... If needed you can increase the dose in the future
Hi, girl! A low dosage will determine if you can tolerate the drug or not. If you have minimal or no side effects your dosage can be raised IF needed. Every individual reacts differently to every medication so this dosage MAY be effective for you.
Meanwhile, think positively! If you think it won't work it probably won't or will only be minimally effective.
Thanks! I think I’m going to try the 1/2 pill, 12.5mg for a minimum of a week if not longer, I did read that therapeutic doses start at 25-50mg but with my history of bad side effects & other meds previously tried not even working I’ll hope for the best!
Related topics
zoloft, depression, obsessive compulsive disorder, premenstrual dysphoric disorder, major depressive disorder, dosage, antidepressant, antidepressants
Further information
- Zoloft uses and safety info
- Zoloft prescribing info & package insert (for Health Professionals)
- Side effects of Zoloft (detailed)
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