For those on Xeljanz, how has it compared to use of other DMARDs and Biologics?

I’m currently on Xeljanz twice daily and methotrexate by injection once/week. I’ve previously been on Plaquenil (allergic), leflunomide along with MTX, and then switched from the oral MTX to shots. From there, I started on biologics and MTX. I went into remission with Enbrel, but it stopped working when I restarted it after sugery. Humira did nothing. Actemra was okay, but I had to take pain medications. I was taken off of it before I knew if it had completely failed because of a significant viral infection last year.
Xeljanz is comparable to the biologics I’ve been on previously, and I’m doing well on it. I’m currently off my MTX for two weeks because I’ve recently had my flu shot, and I’m missing it because my morning pain and stiffness is back, along with some flaring, so it doesn’t seem to work for me without MTX.
My MTX was switched to injections for absorption reasons, but I understand it helps to minimize the gastrointestinal side effects for some people who have those side effects with the pills.
I hope you find your medication that brings you relief!

Hi ab123itsme,
I have tried almost all of the RA drugs with either very bad allergic reactions or they just did not work at all. After 9 years, my Dr. finally suggested Xeljanz. All I can say is that is was the most wonderful choice I have ever made! Not only did it work and work really well, but I have not had any side effects at all. I have more energy and my pain level decreased to a point that I have stopped the Tramadol that I was taking. I do not take any other drug with the Xeljanz. I am allergic to Methotrexate so it is not even considered for me. I hope that you try it. Talk to your Dr. and see if it is possible to not take the Methotrexate at first and instead try the Xeljanz alone. I also went from an inflammation of 95 ( while on Arava) to 5 after 5 months on Xeljanz. My Dr. said I broke all the rules with that big a drop on inflammation. Either way I would consider Xeljanz I am currently on 5mg twice a day by pill. I wish you luck.