Xanax - Is it okay to take Seroquel and alprazolam together at night?

Robert; My friend Masso has already given you the interaction part, I would like to add many people do take these together and because it's at bedtime If you want to lessen the side effect part it helps to keep a little time apart Like take the Xanax 1/2 to 45 minutes before you go to bed, then take the Seroquel right as your going to lay down. And by the way, many of these side effects are not as severe with continued use. good luck.

Interactions between your selected drugs
Moderate
alprazolam quetiapine
Applies to: Xanax (alprazolam), Seroquel (quetiapine)

Using ALPRAZolam together with QUEtiapine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Other drugs and diseases that your selected drugs interact with
Seroquel (quetiapine) interacts with more than 500 other drugs and more than 20 diseases.
Xanax (alprazolam) interacts with more than 400 other drugs and 9 diseases.

Interactions between your selected drugs and food
Moderate
alprazolam food
Applies to: Xanax (alprazolam)

Grapefruit and grapefruit juice may interact with ALPRAZolam and lead to potentially dangerous side effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. Do not drink alcohol while taking ALPRAZolam. This medication can increase the effects of alcohol. You may feel more drowsy, dizzy, or tired if you take ALPRAZolam with alcohol. Talk to your doctor or pharmacist if you have any questions or concerns.

Therapeutic duplication warnings
No therapeutic duplications were found for your selected drugs.

https://www.drugs.com/interactions-check.php?drug_list=1979-1274,133-54

Regards...