Don't understand the difference between the two and haven't been able to locate an answer?
Whats the difference between Statins and Fibrates?
Question posted by tetlin on 6 Sep 2009
Last updated on 6 September 2009 by Marvell
The information on this page reflects personal experiences shared by our community members. It is not reviewed for medical accuracy and should not replace professional medical advice.
Answers
Statins are also known as HMG-CoA reductase inhibitors. They are the most effective drugs in lowering LDL cholesterol. They inhibit HMG-CoA reductase (3-hydroxy-3-methylglutaryl coenzyme A reductase) an enzyme involved in the synthesis of cholesterol, especially in the liver. Decreased cholesterol production leads to an increase in the number of LDL membrane receptors, which increases clearance of LDL cholesterol from circulation.
Fibrates are regarded as broad-spectrum lipid lowering drugs. Their main action is to decrease triglyceride levels but they also tend to reduce LDL cholesterol and help to raise HDL cholesterol. Mechanism of action is not well established. Apparently it decreases plasma levels of triglycerides by decreasing their synthesis. Also reduces plasma levels of VLDL cholesterol by reducing its release into the circulation and increasing catabolism.
Here is a list of Statins:
https://www.drugs.com/drug-class/hmg-coa-reductase-inhibitors.html
And a list of Fibrates:
https://www.drugs.com/drug-class/fibric-acid-derivatives.html
Following links may be useful as well.
https://www.drugs.com/cholesterol.html
https://www.drugs.com/cholesterol-testing.html
https://www.drugs.com/cholesterol-reduction.html
https://www.drugs.com/cholesterol-risk-factors.html
Related topics
cholesterol, fibric acid derivatives, statins
Similar questions
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.