I am sitting here looking at a bottle of Zyprexa 10 MG. After reading all these comments I am scared to take it. I do not want to gain ANY weight my only problem is racing thoughts at night and not being able to turn my mind off and go to sleep. Once asleep I am ok... My doctor has tried many things to help me go to sleep and none have helped. Do I dare try this drug... I am reading about 20 to 30 pounds weight gain in a month. That alone would depress me. I am 5'5" and weigh around 135. Does everyone that takes this drug gain weight?
Zyprexa and weight gain, does this happen to everyone?
Question posted by Beach52 on 24 June 2013
Last updated on 27 October 2023 by Jeremycox777
The information on this page reflects personal experiences shared by our community members. It is not reviewed for medical accuracy and should not replace professional medical advice.
13 Answers
Not everybody. Take melatonin for sleep. It works for me. 47y male.
I was prescribed Zyprexa 5mg for around 10 months and have gained over 12kg. I try to eat one meal per day to mitigate the weight gain.
Starving yourself won't help and is very unhealthy. The best that it can do is prevent a pound or two due to the metabolic changes that Zyprexa is notorious for.
Unfortunately, most if not all psychotropic medications can potentially cause weight gain in some individuals but Zyprexa is by far the worst of the lot.
Ask your doctor to switch you to one of the newer antipsychotics which are somewhat less likely to cause excessive weight gain.
I began taking Zyprexa and Seroquel before that. The Seroquel put 10 lbs on me fast. My dr changed me to Zyprexa and I gained 40 lbs in two months. It screwed w me so bad! U couldn’t wear my clothes. I was now having panic attacks and couldn’t sleep and I was so depressed I couldn’t even leave my pop. I took myself off of the Zyprexa and the weight falling off. Ivost 11 1/2 in two n a half I couldn’t bellieve how fast the results! I still believe my luck. I had fought my weight but now at 55 and I’m thrilled n pray in jHis weigh. I am super tall n feel great at abt 198. So believe it o not that’s my goal. I’m not fat it skinny at that weight. Can’t wait to get the rest of the weight is back. I’ll never go back on the drastic diets pills. I’m bipolar so need something but gain good luck to you!
I can say that yes you will gain weight with olanzapine or Quetiapine both. I’ve gained 40 lbs. I eat one meal a day, trying to loose weight but at night the drugs makes me have a extreme craving for sweets not just one desert at night but one after another until I pass out. Many mornings I wake to find melted chocolate pop cycles in my bed. I take Quetiapine 300mg and olanzapine 10mg, if I don’t take them both I’ll stay awake all night. Today my doctor has taken me off the Quetiapine 300 he wants me to try taking just the olanzapine 10mg. I’m very afraid that it won’t work alone and I’ll stay awake all night. If I don’t sleep tonight he will receive a call first thing tomorrow morning. Say a prayer for me or at least wish me good luck.
It certainly does make you gain weight.I have gained just under 20 pounds since I started zyprexa 4 weeks ago.I also have the shakes for some reason since I started.Ive decided to stop today.
I have been on the generic zyprexa for little over 2 weeks and have already gained 8 pounds. I stay hungry and thirsty. All I want are sweets and carbs. But it has helped with the racing thoughts n I am starting to feel better
It's a great drug, very effective however, I gained 10 lbs in just one week. I do not know if it is water retention. My feet, hands started swelling first. I use it for bipolar this seems to be the only drug that works. I tried it 15 years ago and felt like a fat cow.
I stopped it last night and only if I started going down hill in mood will I go back on it.
But, that's not everyone's experience. I was on lithium and many people report weight, not me.
Be well, hope this helps.
It is impossible to lose weight on Zyprexa. Trust me on that one. Even if you walk 10km every day. Insulin is the side effect medication combined with Zyprexa to treat Mental Illness. Even on the first dose of Zyprexa you can start taking insulin as well even if you are not Diabetic yet. The problems are there are no new medications being developed because Doctors are not interested in this field. The drug companys like E are not concerned about the weight gains people acquire because they make huge profits on their Diabetes medications, the more Diabetics the more money they make. even the law suits the companys have to deal with E has enough funds to survive. it is a minor loss to them or it does not bother them.
Zyprexa is one of the worst offenders when it comes to weight gain. My doctor put me on Zyprexa for Bipolar Type I. I was also taking Lamictal, titrating up to a therapeutic dose, which took several months, so my doc put me on Zyprexa to give me some relief until the Lamictal kicked in. After being on Zyprexa for a week, I felt like I got my life back. I was the old me. Mentally, I was golden. Unfortunately, everything else was not so golden. I gained 60 lbs, was so tired I could hardly keep my eyes open, my cholesterol and triglycerides were through the roof, my sugar was up and I was eating to the point where I would be sick. I was more than happy to get off of this when the Lamictal kicked in. It's an awesome mood stabilizer, works quickly, but the side effects are awful. If you have another alternative, I'd try that instead. Good luck!
I agree.
i am on zyprexa 20 mg am 5'7 and have gained so much weight that i cant lose regardless of diet and excercise! i am so miserable and feel worse than before i started taking for sleep! anyone else have this issue??
You're taking it to help you sleep? No doctor should ever prescribe Zyprexa (olanzapine) for sleep. It is a powerful ANTIPSYCHOTIC, not a sleep aid. Oh yes, it will put you to sleep all right. If only for sleep, you might take 2.5mg, but certainly not 20. 20mg is a high dose even to control hallucinations, much less an off-label use. Look up the prescribing information and drug fact sheet for Zyprexa (the one that doctors look at.) Look at what it can be prescribed for, and the side effects. Weight gain, which can lead to diabetes, is a major side effect. As I said, it should be prescribed for schizophrenia and other instances of psychosis -- not for depression, not for insomnia, not for anything else.
My weight exploded on olanzapine too. I can't remember initial dose as I was in hospital then but I gained 40KG in 6 months. Ridiculous. I switched to seroquel but the weight remained. I'm also on other drugs for fibromyalgia pain so I'm not sure if they cause weight gain/retention as well. I was off of an antipsychotic altogether (just antidepressant and mood stabilisers for mental stuff) for a short while but my sleep suffered so much was going days without sleep due to racing thoughts, that I was put back on olanzapine 10-17.5mg for sleep too. It is an amazing drug for calming the mind, but at the higher dose I gained weight again
yes it was prescribed for sleep and anxiety primarily. no pschyzo effective disorders of any kind here just supremely high anxiety with secondary sleeplessness.
I just started zyprexa 20mg. I'm somewhat active. what kind of weight gain should i watch out for?
I know now that weight gain is a very common side effect, but when I started the drug ~2 years ago my doctor didn't tell me. I have since had weight fluctuations, but not the 20-30 pounds/month. I have also remained within a reasonable range (I'm 5'6'' and my weight is usually between 120-140 and I was 120 when I started taking it). However, I have noticed that the amount of Zyprexa I need to take to actually help my anxiety (I take 10 mg) often makes me feel sluggish and groggy. I am in the process of finding a new medication.
I started these meds immediately before Christmas and I have nearly two stone weight put on in 6 weeks, my clothes dont fit me and i am coming off these meds
Hi, Yes, I am also experiensing severe weight gain!, Can anyone here on this message board recommend an alternative medication or treatment other than Olanzapine/ Zyprexa , so i can try to get off it myself... Thanks
I gain 18 lbs in 3 weeks on Zyprexa. I went back on Seraquil and I'm finally losing it.
This drug makes you gain weight even if you only eat 500 calories a day. No way I'll continue with something that makes me fat. Talk about making me depressed!
If you do not want to gain weight, don't take this drug. I am currently taking 5 mgs of it at night. I'm going to my P Doc and getting off it asap. I have felt like a balloon, blowing up more and more with every day I take it and I don't really see the benefit to it. It's making me crazier by putting weight on me and I haven't even eaten anymore than usual. Stay away from Zyprexa.
Although not everyone will gain weight the chances of gaining weight on Zyprexa are high.
If you have tried other medicines without any success I would suggest that you try this and if you see your weight going up then you can decide whether you'd like to try some other medicine. All the best.
I took one pill. It did not help me sleep until the next day, in other words I did not get immediate results. For 30 hours I ate everything in the house. I did not take another one. Call me vain, but I would be more depressed if i gain 30 pounds. Thank your so much for replying. I am now on a time release Xanax. It also doesn't give me immediate sleep, but I am able to eventually fall asleep. Blessings! Sandy
Hi, I started zyprexa this morning 5mg and my doctor is trying it for 72 hours taking 5mg of a morning. Will this short time of taking zyprexa put weight on? I'm terrified of gaining weight!!
Yes yes yes, one 5 mg pill put ten pounds on me... Bad drug.
My son has gained 40 lbs. over the last year and had a really good metabolism , the pills work great if you have to control a major issue ,it blocks all 17 Neuro transmitters so it is the drug of choice to resolve all issues . That us why it's the go to drug. My daughter was able to wean off this drug ,over a 6 month time frame. She suffered from PTSD and that and Ativan combined pulled her out of it! She was very skinny, with a high metabolism and also gained 35 lbs. over 1yr. Time , but now she is off and much happier!
I am on day 7 of taking zyprexa and I'm happy to be gaining weight. I have extremely high metabolism and it's nearly impossible for me to gain weight. A little over a week ago I was 117 pounds now I'm about 122. For most people gaining weight is not a positive side effect. However I'd have to agree that the chances of gaining weight while taking zyprexa are extremely high.
I took olanzapine (Zyprexa) for about 18 yrs. The first few months, I gained almost 100 lbs. It was horrible to suddenly be obese when I had always been so careful to keep my weight down. I was mortified and the extra weight was depressing. But... I tried almost every antipsychotic on the market and olanzapine was the most effective against my particular symptoms. Many, many negative side effects, but weight gain was the worst for me. I was mostly noncompliant and would only take a small piece of a pill or try to skip it completely the first few years, and was therefore in and out of the hospital constantly. Once I realized I was going to end up in a state hospital, I started taking it more regularly. After 18 years, I stopped taking it (with my doctor's knowledge) and have been antipsychotic-free for 3 yrs. I am doing well so far. I pray that someone will come up with something as effective WITHOUT weight gain. Why can't they do that?
I gained about 40 kg (100ish pounds) on taking olanzapine in 4-6 months. I feel like shaking my psychiatrist and yelling at him for allowing this to happen. Can't remember dose or much info due to ect. I like how it makes me feel but I hate the weight gain. 2 or 3? yearslater I am the heaviest I've ever been (size 22 Australian) and it's miserable, awful, depressing and dangerous to my health. I have chronic pain syndrome and fibromyalgia so exercise is so difficult due to pain and debilitating fatigue. The weight makes my pain worse, it's a viscous cycle. I can control my eating etc in the day really well, but at night I will eat anything that's not nailed down. We've locked the cupboard which helps. On 10mg now for sleep (which doesn't work very well) with a view to wean off it over a few months. I can't wait but I hope I will stay mentally stable.
I would really think carefully before starting treatment on olanzapine, but if you are in danger due to your depression/psychosis you should take it as it works really well for that in my opinion. How tf can we land on the moon and clone a sheep but can't make an antipsychotic that doesn't cause weight gain. Sorry to be so negative. Just struggling at the moment! Best of luck to everyone x
Related topics
zyprexa, weight loss (obesity/overweight), weight
Further information
- Zyprexa uses and safety info
- Zyprexa prescribing info & package insert (for Health Professionals)
- Side effects of Zyprexa (detailed)
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