How much water should I take with levothyroxine?

Hi, Obadiah! There don't appear to be any restrictions or recommendations regarding water intake with the use of levothyroxine ~ just the 8 glasses day that are commonly recommended for all people. You should, however, take levothyroxine on an empty stomach for better absorption and especially avoid foods containing calcium for a couple hours before and after taking it.

ADJUST DOSING INTERVAL: Consumption of certain foods as well as the timing of meals relative to dosing may affect the absorption of T4 thyroid hormone (i.e., levothyroxine). T4 absorption is increased by fasting and decreased by foods such as soybean flour (e.g., infant formula), cotton seed meal, walnuts, dietary fiber, calcium, and calcium fortified juices.

MANAGEMENT: Preparations containing T4 thyroid hormone should be administered on a consistent schedule with regard to time of day and relation to meals so as to avoid large fluctuations in serum levels. Foods that may affect T4 absorption should be avoided within several hours of dosing if possible.