Vitamins interact with drugs??

Yes.

Vitamin D3 interacts with 72 meds:

Source: https://www.drugs.com/drug-interactions/cholecalciferol,vitamin-d3-index.html

Vitamin B12 interacts with 15 meds:

Source: https://www.drugs.com/drug-interactions/cyanocobalamin,vitamin-b12.html

This is the reason why you must inform your Dr. what vitamins/supplements you are taking before you start a new med and also when you have started and want to add a new vitamin/supplement, inform your Dr..