I am on a split dose of methadone 110 total, I took 90 mg this morning. About 13 minutes later I threw up my dose, Im not sure if I threw up my dose or not because I take pills , Does anybody know how long it takes for a does to get into your system? I called and they said 6 minutes but I don' t know if that's the truth because they have said 15 minutes before . I have also heard 45 minutes also an hour. I guess I should just suck it up and deal with it for today. My back really hurts and I am not feeling well but that may be because I have had a stomach virus. Just wondering if anyone knew how long it took?