Sulindac - is this drug used for pain like vicodin at night when going to bed?

No, it won't work "the same". Sulidac is an NSAID, Vicodin is an Opiate. Everyone's metabolisms are different. I was taking Sulidac a long time ago for Rheumatiod Arthritis pain. I didn't think it worked as well as my Opiate pain medications but then again I was addicted and abusing the Opiate pain medications. Opiates seem to "kill" almost all your pain. The Sulidac, at least for me, did not have the same effect. All you can do is try. The only way you'll be able to really tell is to stop taking the Vicodin while you're on the Sulidac.(I know you don't want to do that... right?)Good luck...