I have just started on Effexor XR (75mg) today along with 30mg mirtazapine. I’m currently an inpatient on a psychiatric ward! I am praying this works for MDD Any success stories PLEASE?
Has anybody had success with Effexor XR and Mirtazapine?
Question posted by Wrose86 on 25 Dec 2020
Last updated on 20 May 2021 by BruuceA
3 Answers
BruuceA
20 May 2021
Hi,
I have found Effexor to be the best I’ve ever had, great for depression and panic attacks.
I’m on 150mg per day but if I have too much drama and stress in my life I have to go on 300mg daily for the anxiety.
The only thing you have to watch is do not run out because if you’re late or miss a capsule you will start to get what’s known (in the Effexor community) as brain zaps. They can be unpleasant, once you start getting brain zaps it can can take a few hours for them to stop after taking a capsule being as the med is slow release.
Another tip is only use the genuine brand as in the past some brands released too fast leading to premature zaps.
I’m sorry I can’t advise anything regarding the other med you’re on as I only need the Effexor, in another month you will be a new person.
Good luck and cheers - Bruce.
pjs1957
15 May 2021
Yes - when taken as follows:
MORNINGS: 150mg + 75mg EFFEXOR-XR (locally named "E F E X O R"-XR).
EVENINGS: 30mg Mirtazapine (locally named "AXIT").
Anxiety and depression have been reduced to Normal Levels (whatever normal is - but it works for me).
But be warned - this is for ME - a 64 year old male with recurrent depression and anxiety - and three documented full on break downs.
Discuss with your medical professionals and do no self dose. Just saying.
elandem
26 Dec 2020
This is a highly effective combination. It is known as "California Rocket Fuel". I've been on the combo and it worked really well for me for a while.
Wrose86
26 Dec 2020
Thank you so much! I just need that kick to get me out of here and able to access therapy, exercise, socialise and stop wanting to not be alive! I know it’s not a cure all and I don’t expect it to be. I just want to feel a bit better so I can start to help myself. I’m only on day 2 so I know it won’t be effective yet but I’m hoping it doesn’t take much longer
elandem
26 Dec 2020
In my experience it takes between 1 and 2 weeks to start showing significant effects, so hang in there as best you can till then. It should provide the help you need to to all the other important things to get better.
Wrose86
27 Dec 2020
Did it make you not be able to sleep for the first few days? I’ve not been able to sleep the last couple of nights and I feel like I’ve taken a step back. I’m hoping it’s just a side effect and once I can sleep again the effects will kick in! I just really want to be better :(
elandem
27 Dec 2020
Yes, that is 100% a side effect of both effexor and 30 mg remeron. It will pass in time, however,
if you decrease the remeron to 15 mg it actually HELPS with sleep, so you might suggest that (it is a well known thing). Otherwise, you will adjust and start sleeping better soon -- till then take naps if you can.
Wrose86
30 Dec 2020
Hi, sorry to keep asking you! I just need reassurance! I started the venlafaxine last Thursday and yesterday and the day before I felt like I was really turning a corner and then today I feel almost back to the beginning again! :’( ... is this normal? Will it get better? I think my dose of venlafaxine will be increased tomorrow to 150mg ... could this help aswell?
elandem
30 Dec 2020
Yes, it is completely normal to go up and down in the beginning of taking any antidepressant medication. The fact that you saw a bit of relief is a good sign. Generally you don't see mood improve much at all during the first 2 weeks, and then during weeks 3-6 you should see mood get better slowly. But you will still have ups and downs all along the way. Also, yes, going on on the dose can help too. I don't know your history, but since you are an inpatient I assume you have had some experience with medications not working, but that doesn't mean that this combination will not work. However, if it doesn't there are still many options. My bet is that you will feel much better within a week or so. If you are still not sleeping they can give you something for that in the short term till you adjust to the medication.
elandem
30 Dec 2020
Also, never worry about asking questions, "it takes a village" to get thru depression and I'm glad
to help in whatever small way I can. Hang in there.
Wrose86
31 Dec 2020
Thank you so much! Honestly you have been like my angel and I really feel like I am STARTING to pull through a little bit! I don’t know if I would have done it without your reassurance! I will always be grateful to you - whoever you are! X
elandem
31 Dec 2020
Well that is great news--- starting to slowly feel a bit better is the exact way healing begins, but again, don't worry if you have a few dips along the way--just don't panic.
I'm so glad I have been able to help you. Please reach out whenever you need to.
For now just try to relax and let the medications do their job and hopefully you will be home soon.
Wrose86
3 Jan 2021
Thank you for everything! I think I am going home Thursday! :)
Wrose86
3 Jan 2021
Thank you for everything! I think I am going home Thursday! :)
elandem
3 Jan 2021
That's great news. Just hang tight and remember not to be discouraged if you have a down day or two--full recovery takes weeks/months. But what you can expect is slow and steady progress. Take care and all the best of luck, bev
LLB2021
25 Jan 2021
I just added 37.5 effexor to 30mg mirtazapine, and discontinued wellbutrin. Within the first day of taking the new combination I felt markedly better and more "myself." I had long suspected wellbutrin was not helping me and may have been making me feel worse. I did not know before taking this combination that it was known to be particularly effective and came across that in research. But over the years I have tried many different things (celexa, buspirone, xanax, to name a few) and I have never found a positive effect to occur so immediately. Right now as it's only been a few days I am remaining cautiously optimistic that I may have found the right combination. What I can say is that I have felt varying shades of terrible from low grade depressed to full on hopeless for some time and I feel none of these things now, rather I feel energized and also relaxed and not depressed. Has anyone had seemingly immediate results from this combination of mirtazapine and effexor?
elandem
26 Jan 2021
You probably feel better due to both stopping wellbutrin (it makes me feel awful), as well as the combo of effexor and remeron. Hopefully the trend will hold, but don't be too discouraged if you have a down day here and there. It takes a while to recover from a long stretch of depression and isn't likely to be an "overnight recovery", but again, it's highly likely you feel way better after stopping wellbutrin.
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effexor, effexor xr, mirtazapine, major depressive disorder
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