I've been diagnosed with manic depression and major depressive disorder. It's really hectic to deal with, I know a lot of people are against medication but my doctor brought up that it can improve the quality of my life. I need some positive feedback. Did medication ever help anyone for this? My Effexor XR quit working for my depression a couple months back and it heartbreaking, I'm on max dose of 300mg a day and it don't work like it used to!! Anyone have any advice? I lost my interests in everything In life. Everything I used to love to do, I don't care if I do or not. I don't even feel like going out with friends or talking. I just feel like sleeping and that's it. I have symptoms of manic depression and I've heard it's very hard to treat. My next appointment is soon. Someone have any advice or have been diagnosed with the same as me?