My younger brother has been taking his medication more then prescribed and I would like to know if he does this for a euphoric feeling or not
Does ondansetron make you feel euphoric if you take more then prescribed?
Question posted by Dolamite on 28 July 2012
Last updated on 24 July 2021
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6 Answers
Inactive
12 July 2021
If no overdoses on this medication, Zofran, at 150 mgs IV, and he is legitimately being prescribed by a pain physician, and he is attempting to keep his opioid dose low, is this a bad thing? If, however, he is obtaining oxycodone via illicit means, then we have an entirely different scenario/issue. I'm, legitimately, confused. Could a chat with your brother work? Best wishes to both of you.
Inactive
13 July 2021
I must amend this I just experienced everything the interactions with this Zofran may cause to people on SSRIs. I'm on three. I took several falls thinking it was due to dehydration. First, I couldn't swallow, passed completely out, tried to get up fell again. I had my episode at 4:15 because I was looking at a clock... daylight. Fell again. My mom found me on the floor at 9:15 P.M!!! I instantly fell into a four hour sleep. I woke up to: aphasia, full on panic attack, major hyper mania, jerking as if I had palsy. I thought I was dying. I am convinced it was the Zofran. They need to warn AT PHYSICIAN OFFICE.
Mackintosh
24 July 2021
To the last poster (July 13th, 2021):
I have seen Serotonin Syndrome occur in one of my past employers. She was taking other medications that made adding Zofran to them potentially dangerous. I had to call 911 and she was taken to the hospital where she did stop breathing for at least a minute+? Luckily, they were able to stabilize her, but she stayed in the hospital for weeks.
VancouverMama
18 Sep 2017
No. He may be taking more because he is still nauseous. It does not cause any feelings of euphoria, though I have heard it can make one tired.
Anonygurl
12 Dec 2013
The effectiveness of zofran can decrease over time and taking more can make the patient feel better. If your brother is suffering from chronic nausea I imagine any relief of his symptoms could be euphoric.
merri-not-done
28 July 2012
As an anti-emetic it is like a strong benadryl or dramamine on some ways, and I wondered if its possible he just felt better from whatever med had been making him vomit?
Other that than, I have a vague memory of teenagers abusing dramamine so I guess anything is possible with the right person right med and wrong dose. :-(
LaurieShay
28 July 2012
Just to let you know:
There is no specific antidote for Ondansetron overdose. Patients should be managed with appropriate supportive therapy. Individual intravenous doses as large as 150 mg and total daily intravenous doses as large as 252 mg have been inadvertently administered without significant adverse events. These doses are more than 10 times the recommended daily dose.
In addition to the adverse events listed above, the following events have been described in the setting of Ondansetron overdose: “Sudden blindness” (amaurosis) of 2 to 3 minutes’ duration plus severe constipation occurred in 1 patient that was administered 72 mg of Ondansetron intravenously as a single dose. Hypotension (and faintness) occurred in a patient that took 48 mg of Ondansetron hydrochloride tablets. Following infusion of 32 mg over only a 4-minute period, a vasovagal episode with transient second-degree heart block was observed.
In all instances, the events resolved completely.
While all these events were of short duration, probably not a good idea to overdose on this medication. As far as any "high", I seriously doubt there is much reason to take more than the prescribed amount unless you like being dizzy and having constipation.
kaismama
28 July 2012
It has no side effect of euphoria with appropriate use, but I can't find anything about taking more then prescribed. I did find a rather interesting article on it tho that you might find interesting and applicable : Substance use
Ondansetron lowers the cravings for alcohol, especially in early-onset alcoholics. In one cognitive-behavioral therapy study, ondansetron patients with early-onset alcoholism had fewer drinks per day and reported more days without drinking at all, as compared to the other groups in the study. Also of note, individuals with the LL genotype show significant improvements in alcohol misuse when treated with ondansetron, compared with individuals with the other genotypes of the 5HTTLPR polymorphism, who showed no improvement over placebo.[8][9][10]
Researchers at the Stanford University School of Medicine have demonstrated that ondansetron might be useful and effective for treating withdrawal symptoms of opioid addictions.[11] Unlike the existing treatments methadone and buprenorphine, it is not itself an opioid.[11] Additionally, it does not require continued supervision like treatment with clonidine.[11]
The original experiment used mice who were injected with increasing doses of morphine, assayed with naloxone and then underwent haplotypic analysis to isolate a gene candidate.[12] HTR3A which codes for the 5-HT3 receptor emerged as the primary candidate, which suggested 5-HT3 antagonist ondansetron as a possible treatment.[12] The researchers were then able to show using an acute morphine administration model the efficacy in withdrawal symptom control in humans.[12]
Dolamite
28 July 2012
Well thank you for the informative insight. You explained it well enought for me to understand its effectiveness. I am looking at it now, through the the heavy eyes of a
Man dependent on Prescribed OPIODS, so We now understand its purpose, but the question i want to know is how long it will take to cure a persons withdrawals by ingesting an 8mg Ondansetron.but what really intrigues me is taking your prescribbed roxicontin along with the Ondansetron to hopefully discover that not only are you pain free but any lingering anxiety has floated far from you. My. Curiosity is telling me that is process is legitimate and an enxiety free.
What is your opinion on the matter
Dolamite
28 July 2012
Really strong points you share, and fhe fact that it's a nonarcotic that can give any addict a fighting chance to defeat their demons. Thanks for the responsive
kaismama
28 July 2012
The only contact I've had with it personally was in treating cancer patients getting chemo. I found that info pretty interesting too. If your bro has any trouble with pills or alcohol, he could very well be using it to keep the dose needed down. I don't think he should be taking so much tho, When manufacturers recommend max dosage, they are basing it on 2 things, safety and if the pill is any more effective on an increased dose.
Related topics
obsessive compulsive disorder, ondansetron, medication
Further information
- Ondansetron uses and safety info
- Ondansetron prescribing info & package insert (for Health Professionals)
- Side effects of Ondansetron (detailed)
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