I had been on Zoloft for years and went off of it this winter, and my OCD came through full-fledged. Specifically of the harm variety to myself and others/and exestational. I went back on Zoloft on April 26, 25mg, and increased to 50 on May 13. Last week (week 4/5), and the end of the week before, I felt the best I had ever felt. This week I woke up just as bad as originally. I am hoping that for the first 12 weeks, I should just expect fluctuation. but sometimes, it is so debilitating, and I feel like this is my life forever now.