Does methotrexate cause vaginal thrush?

Side effects for Methotrexate does not include vaginal yeast infection/thrush. There are many other medications that can cause them. The most common is antibiotics. Probiotics are a great way to naturally treat the symptoms especially those found in good quality yogurt. Other wise you may try an over the counter medication like Monistat. Based on your report of taking Methotrexate I am assuming you have or are taking other medications too. It really would be best to call your doctor and report your symptoms to him especially if you have never had the symptoms before.