If I skip a day with Zoloft is that enough time to safely allow me to take a small (.7mg) bit of Melatonin?
Can Melatonin ever be taken while taking Zoloft?
Question posted by deebeee on 3 Oct 2014
Last updated on 13 December 2018 by TrebleReed
Added 3 Oct 2014:
I have reversed sleep (sleep during the day, not by choice) and Melatonin has helped me to sleep earlier vs. falling asleep about 9AM!!! I have CFIDS which almost always includes sleep disturbance. Some say Zoloft can affect Melatonin so it works during the DAY vs. the night!!! Not sure this is a fact or opinion. Melatonin helped me but I don't want to screw up the anti-depressant help I get from Zoloft. We can never win, can we!
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4 Answers
TrebleReed
14 Dec 2018
Zoloft, or sertraline, is an antidepressant in the selective serotonin reuptake inhibitor, or SSRI, class. Studies show that SSRIs may increase the brain’s levels of melatonin, a neurotransmitter that can promote sleepiness and help correct an irregular sleeping pattern. Taking a melatonin supplement with SSRIs that increase the brain’s melatonin levels can enhance the side-effects of melatonin. In one case, melatonin and Zoloft combined with a high-protein diet gave rise to a vision disorder. Given this evidence, it may be best not to mix melatonin and Zoloft.
balbanese
5 Oct 2014
Most folks would be ok with this, while others have reports weird dreams and waking up several times. May be best to get the final OK from your own Dr, who has the best idea how it will affect you personally.
kaismama
3 Oct 2014
I take melatonin and effexor. Never had a problem. You'd probably have more problem if you start skipping your zoloft.
Inactive
3 Oct 2014
Yes you can take them together and you don't need to skip the zoloft. Actually you shouldn't ever be skipping doses of your zoloft or any type of antidepressant unless your doctor told you to do so.
deebeee
5 Oct 2014
Just curious how do you know they are OK together. Would love to read wherever that came from.
I read that since Zoloft is a seratonin uptake med and Melatonin does the same, taking Melatonin negates Zoloft. I actually felt the depletion in the effect of Zoloft when I did take a few drops of Melatonin.
Inactive
5 Oct 2014
There is a med interaction checker at the top of drugs.com. I said it is ok, because most people are fine taking melotonin with an SSRI. However, I think you should discuss all medications and supplements you are considering taking with your physician especially since you felt you're not getting full benefit from the zoloft.
deebeee
6 Oct 2014
It's so weird as I'd googled this before, when I wasn't on this page. Most sites said not to take Melatonin with Zoloft as the Melatonin would incapacitate Zoloft. Now that I'm on this page, when I googled the same thing, now most comments say YES you can take M & Z. Have to ask my shrink when I see him, but thank you so much for checking and caring.
AshleyNave100
8 Sep 2016
I take generic Zoloft at 25mg. for four days and 50mg. afterward. My psychiatrist recently had me on generic Vistaril 25mg. once daily but eventually I didn't have benefits from the medication like I used to. He recommend me to take Melatonin once a night as needed. I will assume that it is safe to take only as directed. Try taking your Zoloft in the morninging and Melatonin in the evening around 6:00 to 6:30 p.m.
Rjworkman
17 July 2018
I checked the interactions between the two and it stated (at least for me when I checked it [6/17/18/ 21:55]) there were no interactions between Zoloft and Melatonin.
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