Medrol Dosepak - Is there usually a risk of weight gain with just taking the one pak of Medrol?

I've never had a problem with just taking 1 dose pac. I don't think you have anything to worry about. Vonnie

Any time time you take steroids there is a possibility of weight gain. Dont let that stop you from taking a medication you truly need. As I have written before, I'm not a huge fan of steroids but there are times where they are truly needed. Most of the weight gain is water weight which you will lose once you are off the med. It can stimulate the appetite so be sure you do not increase your caloric intake and you should be fine.