I had my first injection a week ago. I have stage 4 endo and PCOS. I haven't had any hot flashes yet but I've had a headache everyday since I got the shot. Has anyone else had this problem? I had a large cyst removed from my left ovary about four months ago so my doctor recommended Lupron for six months. I work and go to school so I don't know how I'll handle it if the side effects get really bad.