... into Lexapro and it's just not working for me. I just gotta clear this cloud of darkness and my doc mentioned he might switch me to Zoloft if no improvement in the Lexapro. I appreciate anyone's experience in this regard, and/or comparison experiences. Having to go thru another 3 weeks of testing another med just kills me ... so I'd like to think the switch to Zoloft is the right choice ... I know it's different for each person. We went with Lexapro first because of it's alleged positive effects on anxiety, which I do have. Many thanks for your shared experience and wisdom; this site is such a valuable support tool
Lexapro vs Zoloft Hi all, Anyone switched from Lexapro to Zoloft successfully ?. I am 3 weeks?
Question posted by khunlob on 27 April 2013
Last updated on 1 August 2020 by BB79
The information on this page reflects personal experiences shared by our community members. It is not reviewed for medical accuracy and should not replace professional medical advice.
12 Answers
Hi, I started Lexapro 10mg in December of 2019 after my first panic attack. About two months ago my Dr decided to gradually up the dosage to 15mg. Then slowly to 20mg because I felt like it just wasn’t doing any good anymore. I was on the 20mg for a week and had a major panic attack so she backed me down to 15mg. On my next visit she decided to switch me over to Zoloft. I forgot to mention I was diagnosed with panic disorder. She started me on a cross taper where I took a low dose (10) of Lexapro and 25mg of Zoloft. 3 days in and I had a massive panic attack, worse than ever. I was extremely agitated and racing, crazy thoughts. Day 4 same. So I called her and just today dropped Lexapro altogether and upped Zoloft to 50mg. We’ll see how it goes. I will update this post in a few days. I also keep Ativan on hand for emergencies
I’m asking the same question Lexapro handled my anxiety well but my depression got really bad. I’m on 20mg of Lexapro and just stared 12.5 mg of Zoloft my anxiety is already tweaking. Not bad enough for a Xanax but close. Hands just start shaking. I took Zoloft about a 2 years ago it worked well ran into a stressful situation. I was at 75 mg when doctor increased it to 100mg my mind just went anxiety overload. Ended up in hospital ER went into out patient program for 3 months. Did well was put on Effexor had really bad racing heart. They changed me to Remeron slept well my depression put me in physic unit for a week. Then they put me on Paxil got me so nauseated stayed on it for 3 months. Then Lexapro staring at 2.5 up to 22.2 in over a year. My depression just worsened so she wants me back on Zoloft again. I’m so burned out and scared I’m doing the right thing.
Hi there! There are a lot of antidepressants out there! It really just depends on the one you can find that will work with your body chemistry. Don't be afraid to let your doctor know if one isn't doing it. You can switch from one to the other, he/she will probably give you a low dose to start with. Me personally, I went from Paxil {made me sweat} to Prozac{made my angry} to Zoloft and I was fine. I had panic attacks from work and everyday stress. I finally got off of it {after changing jobs etc :},,just know to find the right one for you and it should help you out! Hang in there! It does get better!
Hello all! I just joined this forum to share my experience with lexapro. I was on it for a year about 3 years ago. It worked wonders for my anxiety then somehow it stopped working. I thought maybe it was just a bad batch of the meds during manufacturing. I started weaning myself from it & stopping was not pretty. I had violent vomiting for a few days. Throughout the course of the last 3 years I tried paxil & Zoloft but I only last a few days & stopped. Paxil is the worst it made me very suicidal. Zoloft seems better but I just didn't want to be on any drugs so I changed my lifestyle a bit. Exercise helps a lot, it is hard to get into the treadmill but I pushed myself. I also try to do lots of chores at home, cleaning the bathroom, basement & climb the stairs where I work. I learned how to meditate which made the biggest difference. Anxiety & depression are tough for anyone but I always tell myself that life is good and God will not give me anything I cannot handle. I will keep writing here and will share my meditation experience in my next comment.
I have been taking anti depressants for 45 years, this, that and the other. Have had a lot of tragedies in my life and this is how I have gotten through. I just took my last 10 mg of Lexapro this am and I am now starting Zoloft 50 mg. I too have been in a dark depressing cloud as well as problems with my husband for my lack of interest in him and my sexual desires. I love him dearly but he sooo questions that from the way I am feeling. Please wish me luck and I am praying for good results for you.
why do you poison yourself with these drugs? life is one, libido is life. no libido, no life
No life, no libido
I am so glad I found this thread! I have been having a really rough time with Lexapro and feeling very discouraged because it seems like all I can find is stories of people who have had life-changing results from Lexapro... my experience has been less than stellar.
I have been taking 10 mg of lexapro for a few months and am just not seeing the results I was expecting. The side effects starting up were DREADFUL: increase in anxiety to the point where I had a hard time getting out of bed and - like another user said - wanted to pull off my skin. I have also noticed a rebound of depression symptoms (I have been depression-symptom-free for about 10 years, so this was not a happy discovery). And I have lost 20 pounds due to loss of appetite. And while I was a bit overweight before the weight loss, I just don't feel *good* about it since it's happening because I have a hard time eating.
How this relates to zoloft... well... I took zoloft for years with good results (between 100 and 200 mg depending on circumstance) and then I felt like it "stopped working". My doctor switched me to Viibryd (an SNRI) for about a year and it was not a good fit. Following a bout with acute anxiety and panic attacks (daily - fun!) she switched me to Lexapro. And now I'm wondering if I can go back to the zoloft and gain the same therapeutic benefit since it's been a while since I took it.
I am seeing the doctor today - I'm hoping she will recommend going back to the zoloft as I have been suffering on the Lexapro. And yes, in answer to your question, there will probably be another few weeks of adjustment if you switch between the two, but that's just part of the nature of the beast with SSRIs. I find that during the transition period, I try to focus on taking it one day at a time and reminding myself that "this too shall pass". It helps keep it in perspective a bit. Oh and of course keeping the Ativan handy juuuuust in case.
Hi dopey:
I had similar experiences with lexapro, and also with zoloft years ago. If you would like to try another AD that has worked well for many people, and for me, I take Wellbutrin SR. Some people say it makes them anxious. I take it to alleviate my anxiety. It calms me. It gives me energy and motivation. Just food for thought for you...
@dooey: I am so sorry! My "spell correct" changed your name and I didn't see it till I had already posted. I hate that thing. My apologies to you!
do you not worry losing your libido permanently by using these drugs?
I was on Lexapro 10mg which worked well but I couldn't handle the side effects. Taking 50mg of Zoloft for the past 10 days and its a miracle drug for me. Had some ubpleasant side effects-shaking, digestive issues but they are slowly going away. I have even cut down on the xanax as this drug is really working for my severe anxiety. I highly recommend it.
Hi, today is my first day on zoloft, I've been on lexapro 10 mg for about 8 months. Lexapro literally was a life saver for my anxiety and really helped me get out of the cloud of depression that was on me at the time. I had started to experience erectile disfunction (twice but I'm 24 and that's too young for this problem), and also experienced more and more delayed ejeculation (nice at first and with new girls but actually is a huge inconvenience when you're trying to build a relationship. Very frustrating!)
My doctor suggested zoloft so we'll see how it goes. That may have been tmi for some, but if you're a male and your plumbing isn't working how it's supposed to, it can be very troubling.
Hi,
I was diagnosed with bipolar, ptsd borderline skitzophrenia, depression, anxiety. I was originally prescribed Lexapro which made me very edgy. I switched to zoloft about a year later and havent looked back. Meds allow me to work on my disorders i have found that intense therapy in addition to a proper regimine of meds have helped tremendously. I read alot of positive self help books as well and really latched on to them. I now lead a happy 'normal' life. Best of luck! Looking back i was also on vistaril pretty liberally that helped for awhile too but stopped working when i used it all the time.
I started off on Lexapro and had a horrible experience with it-I only stayed on it for a week and then switched to Zoloft. The week I was on Lexapro, my anxiety got so bad, I would curl up on the floor and just want to crawl out of my skin. I couldn't carry on a conversation and my heart raced like crazy. After I told the Dr. my heart raced nonstop and my anxiety had increased, she took me off the Lexapro and switched me to Zoloft. I gradually went up to 50 mg of Zoloft and I'm doing fine-I've also made some life style changes-which I would like to think has helped too. OH and I take Klonopin as needed-I haven't really needed it in about 3 weeks.
I am so happy to hear this. I have been on Lexapro for 1 week and it has been awful. I've feel so much anxiety and it felt like blood was just pumping way to fast through my whole body. I would get these flashes of heat going through me like my insides where on fire. I just called my doctor and she told me to stop and start taking 25 mg of Zoloft and we'll take it from there. I pray I have as good an experience as you. Good luck!
I wish you the best on Zoloft. It did wonders for me. Please keep in mind that 25 mg is pretty low, but my body couldn't even tolerate 25 mg at first. I broke mine in half (pill cutter) and took 12.5 mg for awhile (about a week), then eased up to 25 mg (for about 2 weeks or so) and eventually got up to 50mg. The whole process to get up to 50 mg was about a month. It worked wonderfully for me. I could laugh again, my heart stopped racing, I didn't feel like I was in a fog anymore. I can now say that I have weaned myself off of Zoloft and the only thing I need now is a sleeping pill. I hope you have the same experience, but if not, go back to your dr. and see what else you can try-there are so many out there! Good luck!
We'll day I from the Lexapro to the Zolft I felt like a normal human being again, it was a wonderful break. But then last night all of a sudden I started getting that crazy heat feeling going through my whole body again and then this causes me to panic and let's just say it wasn't good. Took a Klonopin and finally fell asleep. My doctor told me to go off the Zolft for three days to allow the Lexipro to completely get out of my system and then we'll try Zoloft again. It is so crazy this heat feeling that I experience. Well I hope your still doing well. Anxiety is so awful and I just want to get it under control already. I'm wondering if you're willing to share some other things you're trying? I appreciate your comments, makes you feel better when you're not alone.
I remember those days/nights all too well-wasn't that long ago for me! It sounds like your body has a hard time adjusting to meds too-I'm very sensitive. I would try cutting the zoloft in 1/2 so its like 12.5 mg-then slowly build up-stay on that for a week, then go to 25 mg, then gradually up to 50-which is the therapeutic dose. I kept the klonopin with me-and I took it as needed-which was a lot at first. I also joined the gym and started running and taking yoga classes... I have never been a fan of group exercise, but having other people in there with me for whatever reason helped-support group, could laugh at ourselves, etc.
I also locked myself in the bathroom every night and took a long hot bath where I tried to read and just block out all the noise in my brain. Don't get me wrong, when I first started these, it was hard..it was hard for me just to get out of bed-but I made myself and after awhile, I looked forward to the gym and taking that long bath each night. One very important question... are you sleeping?? I couldn't sleep which added to my anxiety. I went to a sleep specialist and he was amazing. He suffered from anxiety and insomnia too so knew exactly where I was coming from. He prescribed me a LOW dose of mirtazapine (3.25) which I take at night (as needed now) and it helps me get the sleep I need which can really lower your stress/anxiety levels. I don't mind helping you-I went through this and I know how awful it is. Just remember, it WILL get better.
I just want to thank you again for your comments. I don't have an issue with sleeping, so I guess I got lucky there. I am going to do as my Dr. suggested and stay off the Zoloft for a couple days in hopes to get all the Lexapro out of my system and the I think I'll do as you suggested and take 12.5 to build myself up to the 50 mg and use Klonopin in the interim until the Zoloft takes full affect. I know that exercise is a wonderful tool, but sometimes when your feeling so bad it's hard to motivate, but I guess you just have to push through. For me, when I am "in the moment" of a full blown anxiety attack I don't even want to move, I almost feel like I can't. It is so debilitating. Well today has been a good day, and I am sure the Klonopin has helped that : ) I pray each day gets better and I will pray for your continued success in concurring this ugly beast.
I know we are better than this anxiety and have the power to control it, sometimes are just harder than others. My biggest fight is that when it is happening convincing myself that it will pass and it is not life threatening. That is my biggest challenge, I have catastrophic thinking. Good luck again and I wish you many peaceful nights sleep.
Please keep me posted! I felt the same way when I was having a full blown panic attack-I didn't want to move and I was so scared. I remember some new neighbors came over once and I couldn't even get up to introduce myself-it was horrible. As someone who had never had these before, I thought I was going crazy and had no idea how to pull myself out of it. I did see a therapist as well-it really helped to talk about what was going on to someone that didn't really know me, plus she had suffered from anxiety attacks when she was my age. I saw her for about 6 weeks and during that 6 weeks is when I slowing started going to the gym and also when I was able to get myself up to the full 50 mg of Zoloft. It takes time, but you can fight this. Take that Klonopin as needed and slowly get your body/brain use to the Zoloft... I hope you feel better soon.
Are you ladies still on this feed? I have questions if so!
I still get questions sent to me although I no longer take anything. Everything OK?
I was on Zoloft for 7yrs and it did great for my anxiety and panic attacks, but didn't do so well for depression. I've been taking Lexapro for 7 or 8 months now & I can say it does well for my depression; however, for the last month I have experienced a lot of anxiety with panic attacks starting in this last week. I no longer take Zoloft, but I have been trying to decide if I want to switch from Lexapro. I take 10 mg a day. 20 mg make me feel like I am just there. I cannot stand the anxiety & panic attacks. Prozac didn't do anything for me either when I very first took it 9 yrs ago.
I just don't know what to do?
Personally, Zoloft gave me significantly worse side effects than Lexapro has. I've been on Lexapro a little over a month now and I don't think my dosage is quite right, but it's sooo much better for me than Zoloft. Zoloft made me extra lethargic and suicidal and I was on it for almost a year before my doc made the switch. It's different for everyone, remember. They're miracle drugs when then work right :)
do you not worry about loss of libido etc? after all, the life is one. without libido, life has no meaning
This is a very, very old thread but if there is any chance you might see this KT1975... I started Lexapro on Monday and this EXACTLY what I experienced. I started with .5 MG of lexapro on Monday and after four days (yesterday) called my doctor and told her I couldn't take this anymore, for exactly what you described. She told me that since I had only taken an equivalent of 2.0 MG that I didn't have to be weened, and instead prescribed me 25 MG of Sertraline (zoloft) instead. Our stories are so similiar. How long did your Lexapro withdrawal last? How did you do on zoloft? THANK YOU!
I had been on lexapro for awhile years back. It worked at first... but then I felt like It wasn't working enough. Since then I have tried many other meds. I have now just switched from prozac to zoloft... which I have been on before. My doc has me gradually increasing the dose. I seem to be doing well on it along with welbutrin. I do hope it works for you also. take care
You should be feeling somewhat better. It does take awhile. I am on zoloft and I am not doing as well as I want to be. But, she started me out on 25mg, then to 50mg and I just started it on 75mg. She is working me up slowly. I see some improvement, but, hopefully when I go back, I can go to 100mg and it will work fine. My husband is on 100mg and is doing good. I used lexapro once and it worked. I decided to try other meds because of tv commercials, such as cymbalta and abilify. Didn't work. She wanted to try the zoloft so here I am, trying. Good Luck.
I have used Zoloft for years it worked in the prior years but as for my anxiety has increased I am investigating what else to try. Going to doctor today also the Zoloft made me gain about 10-20 pounds and it does affect your libido
Sorry took 50mg was changed to 75mg a couple months ago
do you not worry about loss of libido etc. with these drugs?
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